Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Adolph Bohnstedt"'
Autor:
Celia Kingsbury, Irina Neagu, Ming You, Haengsoon Park, Tsung H. Lin, Koc-Kan Ho, Elizabeth Quadros, Maria L. Webb, Michael Ohlmeyer, Yuefei Shao, Matthew Sills, Jeffrey J. Letourneau, Andrew G. Cole, Yingchun Lu, Earl F. Kimble, Jorge Quintero, Riviello Christopher, Ray Anthony James, Bojing Wang, Vidyadhar M. Paradkar, Adolph Bohnstedt, Kenneth C. Appell, David J. Diller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6788-6792
A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd21d26420d59e8a1c379ce66894ef1
https://doi.org/10.1016/j.bmcl.2009.09.080
https://doi.org/10.1016/j.bmcl.2009.09.080
Autor:
Martin-Jan Smit, Jac C. H. M. Wijkmans, Rong-Qiang Liu, Jaap van der Louw, Koc-Kan Ho, Jim Inglese, Shawn David Erickson, Ming You, Ellen Son, Andrew Laird Roughton, Douglas S. Auld, G.M.T. Vogel, Christopher M. Masterson, Paolo Conti, Daming Feng, Martijn Rooseboom, Adolph Bohnstedt, Celia Kingsbury, Maria L. Webb, Steven G. Kultgen, Yajing Rong, Michael Ohlmeyer, Philippe Samama, Wim Dokter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2724-2728
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e77595dde5f19c6adc662437d25282
https://doi.org/10.1016/j.bmcl.2006.02.028
https://doi.org/10.1016/j.bmcl.2006.02.028
Autor:
Zoran Rankovic, Hardy Sundaram, Guizhen Dong, Maria L. Webb, Edward Mcdonald, Adolph Bohnstedt, Tao Guo, Koc-Kan Ho, Steven G. Kultgen, Christopher M. Masterson, Khondaker R. Islam, Robert A. Horlick, J. Richard Morphy, Baldwin John J, Kirk Mcmillan, Kenneth C. Appell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:545-548
Structure-activity studies on benzamide 1 obtained from library screening led to the discovery of a novel series of potent and selective glycine transporter type-2 inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384842067b150363b62c90e14d82e7aa
https://doi.org/10.1016/j.bmcl.2003.09.080
https://doi.org/10.1016/j.bmcl.2003.09.080