Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adolfo Varona"'
Autor:
J. M. De Gandarias, Javier Gil, David Fernandez, Adolfo Varona, Luis Casis, J. Irazusta Astiazaran
Publikováno v:
Arzneimittelforschung. 49:816-819
Lithium (CAS 7439-93-2) is being utilized widely for the treatment of manic-depressive illness. However, the neurochemical mechanism of the ion action still remains relatively obscure. In the present work, the effect of acute lithium administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c92344fa39de55c144602a279ff0799
https://doi.org/10.1055/s-0031-1300507
https://doi.org/10.1055/s-0031-1300507
Autor:
José I. López, Itxaro Perez, Adolfo Varona, M. Luz Candenas, Lorena Blanco, Francisco M. Pinto, Gorka Larrinaga, Jon Irazusta, Javier Gil, Begoña Sanz
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Consejo Superior de Investigaciones Científicas (CSIC)
6 páginas, 3 figuras, 3 tablas. The angiotensin-converting enzymes (ACE and ACE2) are highly expressed in renal tubules and play an important role in the regulation of renal function by the intrarenal renin-angiotensin system (iRAS). Dysregulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86593789a04a4042b50dd0ce8ab109d
https://doi.org/10.1016/j.regpep.2010.07.170
https://doi.org/10.1016/j.regpep.2010.07.170
Autor:
Carmen Etxezarraga, Leire Andrés, Gorka Larrinaga, Francisco Santaolalla, Adolfo Varona, José I. López, Itxaro Perez, Jon Irazusta, Lorena Blanco, Aitor Zabala
Publikováno v:
Regulatory Peptides. 163:102-106
Prolyl endopeptidase (EC 3.4.21.26) (PEP) is a serine peptidase that converts several biologically active peptides. This enzyme has been linked to several neurological, digestive, cardiovascular and infectous disorders. However, little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae0292773c831cbcbcd70761d42a013
https://doi.org/10.1016/j.regpep.2010.03.012
https://doi.org/10.1016/j.regpep.2010.03.012
Autor:
Gorka Larrinaga, Adolfo Varona, Javier Gil, José I. López, Luis Casis, Lorena Blanco, Ekaitz Agirregoitia
Publikováno v:
Regulatory Peptides. 144:56-61
The involvement of peptidases in carcinogenetic processes of several tumor types has been researched in recent years. Although kidney is one of the major tissues known to express cystinyl-aminopeptidase (CAP), little is known about its role in renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7ad27f832f9f1b08954379fbe66616
https://doi.org/10.1016/j.regpep.2007.06.002
https://doi.org/10.1016/j.regpep.2007.06.002
Autor:
Adolfo Varona, Naiara Agirregoitia, Jon Irazusta, M.P. Martín del Río, Raúl Laiz-Carrión, Juan Miguel Mancera
Publikováno v:
Journal of Comparative Physiology B. 175:433-444
Peptides play important roles in cell regulation and signaling in many tissues. The actions of peptides are regulated by peptidases. Although the activity of these enzymes has been thoroughly characterized in mammals, little is known about their pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ce19c57827fd14e1140c6e23a9f8b9
https://doi.org/10.1007/s00360-005-0011-5
https://doi.org/10.1007/s00360-005-0011-5
Autor:
Adolfo Varona, Elaine Gasparello-Clemente, Javier Gil, Luis Casis, Jon Irazusta, Paulo Flavio Silveira
Publikováno v:
Peptides. 24:1367-1372
Enzymatic cleavage of some peptides in the local environment could be included among the mechanisms related to the regulation of hydrosaline balance. In order to examine this hypothesis, we measured representative aminopeptidase activities in viscera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b910968970d8156155f03644967ec8
https://doi.org/10.1016/j.peptides.2003.08.006
https://doi.org/10.1016/j.peptides.2003.08.006
Publikováno v:
Regulatory Peptides. 110:225-230
The endogenous opioid neuropeptide system seems to be involved in the neural processes which underlie drug addiction. Several studies have reported that the administration of morphine induces changes in the levels and/or activity of endogenous opioid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134ca72d7e7630429dca42a67d9cb491
https://doi.org/10.1016/s0167-0115(02)00218-5
https://doi.org/10.1016/s0167-0115(02)00218-5
Publikováno v:
Hormone and Metabolic Research. 35:36-42
In order to examine the possible relationship between the processing and inactivation roles of aminopeptidases and the disruption of water-electrolyte balance, we measured the activities of aspartyl aminopeptidase (Asp-Ap), arginyl aminopeptidase (Ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985e98ada9068cdf4000687e53c82942
https://doi.org/10.1055/s-2003-38389
https://doi.org/10.1055/s-2003-38389
Publikováno v:
Neurochemistry International. 35:357-361
Neonatal handling decreases neutral endopeptidase 24.11 activity in the amygdala. However, this procedure does not affect aminopeptidase activities in any of the brain areas studied. Neonatal handling has been one of the most commonly used strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077d4d08158f419f92287bb6aeef79f1
https://doi.org/10.1016/s0197-0186(99)00080-7
https://doi.org/10.1016/s0197-0186(99)00080-7
Publikováno v:
Neurotoxicology and Teratology. 20:611-616
Benzene is a widely used industrial neurotoxin. Its action in the brain is not completely clear. Acute exposure to benzene in vivo reduces aminopeptidase activity in the hypothalamus and in the brain stem, and in vitro treatment with this toxicant ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5f449b6156d0624a2c93da229461ce
https://doi.org/10.1016/s0892-0362(98)00015-4
https://doi.org/10.1016/s0892-0362(98)00015-4