Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Adolfo Garcia-Ocaña"'
Autor:
Liora S. Katz, Gabriel Brill, Peng Wang, Luca Lambertini, Pili Zhang, Jonathan M. Haldeman, Hongtao Liu, Christopher B. Newgard, Andrew F. Stewart, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101848- (2024)
Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose is a natural β-cell mi
Externí odkaz:
https://doaj.org/article/ca3bb72876334491840e4095754b390d
Autor:
Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey, Emma F. Johnson, Nicolás Gómez-Banoy, Carolina Rosselot, Jennifer Wen, Tahmina Hossain, Marcus D. Goncalves, James C. Lo, Adolfo Garcia-Ocaña, Timothy E. McGraw
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101831- (2023)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Ty
Externí odkaz:
https://doaj.org/article/08e30cb16fb344d1bf22ff6b6349e352
Autor:
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
ChREBP is a glucose-responsive transcription factor, which regulates glucose-mediated proliferation and cell death in pancreatic β-cells. Here the authors show that the acute feed forward induction of ChREBPβ is required for adaptive β-cell expans
Externí odkaz:
https://doaj.org/article/f2c908c5343543e98a1a127b3ec55963
Autor:
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/de30955e01f54ed4b9fb1d77ba69bc7b
Autor:
Peng Wang, Esra Karakose, Lauryn Choleva, Kunal Kumar, Robert J. DeVita, Adolfo Garcia-Ocaña, Andrew F. Stewart
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
A quantitative deficiency of normally functioning insulin-producing pancreatic beta cells is a major contributor to all common forms of diabetes. This is the underlying premise for attempts to replace beta cells in people with diabetes by pancreas tr
Externí odkaz:
https://doaj.org/article/afbe04c366a34476897b46b01b7cd797
Autor:
Sanda Ljubicic, Klaudia Polak, Accalia Fu, Jessica Wiwczar, Benjamin Szlyk, Yigang Chang, Juan C. Alvarez-Perez, Gregory H. Bird, Loren D. Walensky, Adolfo Garcia-Ocaña, Nika N. Danial
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 497-504 (2015)
Strategies that simultaneously enhance the survival and glucose responsiveness of insulin-producing β cells will greatly augment β cell replacement therapies in type 1 diabetes (T1D). We show that genetic and pharmacologic mimetics of the phosphory
Externí odkaz:
https://doaj.org/article/0507c2fc999c4b9fb8688a6e0e999254
Autor:
Anaïs Mozar, Hugo Lin, Katoura Williams, Connie Chin, Rosemary Li, Nagesha Guthalu Kondegowda, Andrew F Stewart, Adolfo Garcia-Ocaña, Rupangi Chhaya Vasavada
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158414 (2016)
Finding ways to stimulate the regeneration of endogenous pancreatic beta cells is an important goal in the treatment of diabetes. Parathyroid hormone-related protein (PTHrP), the full-length (1-139) and amino-terminal (1-36) peptides, enhance beta ce
Externí odkaz:
https://doaj.org/article/c67d90186e754307a40bc28ea7f7724c
Autor:
Robert J. DeVita, Andrew F. Stewart, Adolfo Garcia-Ocaña, Peng Wang, Kunal Kumar, Chalada Suebsuwong
Publikováno v:
Journal of Medicinal Chemistry. 64:2901-2922
According to the World Health Organization (WHO), 422 million people are suffering from diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose control to prevent long-term diabetes complications. Unfortunately, current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a78d091e1f547ca55906ac1a308cd4f
https://doi.org/10.1021/acs.jmedchem.0c02050
https://doi.org/10.1021/acs.jmedchem.0c02050
Publikováno v:
Trends Endocrinol Metab
Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive oxygen species, defective glucose-stimulated insulin secretion, decreased insulin production, and eventually β cell death and diabetes. Nrf2 is a master regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b2b867ec055bc93c42ce41f85dda4d
https://doi.org/10.1016/j.tem.2020.11.002
https://doi.org/10.1016/j.tem.2020.11.002
Autor:
Gregory H. Bird, Accalia Fu, Jarrod A. Marto, A. M. James Shapiro, Loren D. Walensky, Mehmet G. Badur, Scott B. Ficarro, Lindsay Evans, Andrew F. Stewart, Dong Wook Choi, Russell G. Jones, Gaëlle Bridon, Nika N. Danial, Adolfo Garcia-Ocaña, Carolina Rosselot, Daina Avizonis, Hyuk-Soo Seo, Tatsuya Kin, Juan Carlos Alvarez-Perez, Sirano Dhe-Paganon, Esra Karakose, Jurre J. Kamphorst
Publikováno v:
Nature metabolism
Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms that determine cellular sensitivity to inflammation are incompletely understood. Here, we show the contribution of glucose metabolism to inflammation-induced ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67f448ef2601ba6e86374e56eda7e3a
http://europepmc.org/articles/PMC7568475
http://europepmc.org/articles/PMC7568475