Zobrazeno 1 - 10
of 940
pro vyhledávání: '"Adolfo García‐Sastre"'
Autor:
Gagandeep Singh, Juan García-Bernalt Diego, Prajakta Warang, Seok-Chan Park, Lauren A. Chang, Moataz Noureddine, Gabriel Laghlali, Yonina Bykov, Matthew Prellberg, Vivian Yan, Sarabjot Singh, Lars Pache, Sara Cuadrado-Castano, Brett Webb, Adolfo García-Sastre, Michael Schotsaert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Antigenically distinct SARS-CoV-2 variants increase the reinfection risk for vaccinated and previously exposed population due to antibody neutralization escape. COVID-19 severity depends on many variables, including host immune responses, wh
Externí odkaz:
https://doaj.org/article/46ae414f37534b03abee97ae46222fe4
Autor:
Raveen Rathnasinghe, Lauren A. Chang, Rebecca Pearl, Sonia Jangra, Amy Aspelund, Alaura Hoag, Soner Yildiz, Ignacio Mena, Weina Sun, Madhumathi Loganathan, Nicholas Alexander Crossland, Hans P. Gertje, Anna Elise Tseng, Sadaf Aslam, Randy A. Albrecht, Peter Palese, Florian Krammer, Michael Schotsaert, Thomas Muster, Adolfo García-Sastre
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Influenza viruses pose a threat to public health as evidenced by severe morbidity and mortality in humans on a yearly basis. Given the constant changes in the viral glycoproteins owing to antigenic drift, seasonal influenza vaccines need to
Externí odkaz:
https://doaj.org/article/dccfdfa0d19945a6be803b54e7f7865b
Autor:
Ethan C. Veit, Madihah S. Salim, Mariel J. Jung, R. Blake Richardson, Ian N. Boys, Meghan Quinlan, Erika A. Barrall, Eva Bednarski, Rachael E. Hamilton, Caroline Kikawa, Nels C. Elde, Adolfo García-Sastre, Matthew J. Evans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Zika and dengue virus nonstructural protein 5 antagonism of STAT2, a critical interferon signaling transcription factor, to suppress the host interferon response is required for viremia and pathogenesis in a vertebrate host. This affects vir
Externí odkaz:
https://doaj.org/article/c1492f081af343ca9b56c04dbdd379b3
Autor:
Linda M Sircy, Andrew G Ramstead, Lisa C Gibbs, Hemant Joshi, Andrew Baessler, Ignacio Mena, Adolfo García-Sastre, Lyska L Emerson, Keke C Fairfax, Matthew A Williams, J Scott Hale
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1011639 (2024)
Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in
Externí odkaz:
https://doaj.org/article/67badab4cd554c29b4561222bf73923a
Autor:
Sara Monzón, Sarai Varona, Anabel Negredo, Santiago Vidal-Freire, Juan Angel Patiño-Galindo, Natalia Ferressini-Gerpe, Angel Zaballos, Eva Orviz, Oskar Ayerdi, Ana Muñoz-Gómez, Alberto Delgado-Iribarren, Vicente Estrada, Cristina García, Francisca Molero, Patricia Sánchez-Mora, Montserrat Torres, Ana Vázquez, Juan-Carlos Galán, Ignacio Torres, Manuel Causse del Río, Laura Merino-Diaz, Marcos López, Alicia Galar, Laura Cardeñoso, Almudena Gutiérrez, Cristina Loras, Isabel Escribano, Marta E. Alvarez-Argüelles, Leticia del Río, María Simón, María Angeles Meléndez, Juan Camacho, Laura Herrero, Pilar Jiménez, María Luisa Navarro-Rico, Isabel Jado, Elaina Giannetti, Jens H. Kuhn, Mariano Sanchez-Lockhart, Nicholas Di Paola, Jeffrey R. Kugelman, Susana Guerra, Adolfo García-Sastre, Isabel Cuesta, Maripaz P. Sánchez-Seco, Gustavo Palacios
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or subclade IIa MPXV, possibly cause
Externí odkaz:
https://doaj.org/article/b702225a6b8044b886dd81bd6742679e
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114960- (2024)
Summary: Viral infection triggers a rapid and effective cellular response primarily mediated by interferon β (IFNβ), which induces an antiviral state through complex signaling cascades. To maintain a robust antiviral response while preventing exces
Externí odkaz:
https://doaj.org/article/2bfe7e192c4d4676b1f66b6c1d8b8cd2
Autor:
Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V. Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolfo García-Sastre, Michael Schotsaert, John R. Teijaro, Hong M. Moulton, David A. Stein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102331- (2024)
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5′END-2, targeting a highly conserved
Externí odkaz:
https://doaj.org/article/cde8602c5de243599a35a2d086e74e3b
Autor:
Pingping Wang, Jianing Guo, Yefan Zhou, Min Zhu, Senbiao Fang, Fanyuan Sun, Chongqiang Huang, Yaohui Zhu, Huabo Zhou, Boyu Pan, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Adolfo García-Sastre, Ying Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
The vast majority of data obtained from sequence analysis of influenza A viruses (IAVs) have revealed that nonstructural 1 (NS1) proteins from H1N1 swine, H3N8 equine, H3N2 avian and the correspondent subtypes from dogs have a conserved four C-termin
Externí odkaz:
https://doaj.org/article/31460f6a37144bf794364fc271b7cbcd
Autor:
Chongqiang Huang, Liangzheng Yu, Yi Xu, Jiamo Huang, Yibin Qin, Xuan Guo, Yongfang Zeng, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Adolfo García-Sastre, Ying Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTInfluenza A viruses (IAVs) pose a persistent potential threat to human health because of the spillover from avian and swine infections. Extensive surveillance was performed in 12 cities of Guangxi, China, during 2018 and 2023. A total of 2540
Externí odkaz:
https://doaj.org/article/494c70480c974a4ca1ca874e769a0402
Autor:
Alba Escalera, Manon Laporte, Sam Turner, Umut Karakus, Ana S. Gonzalez-Reiche, Adriana van de Guchte, Keith Farrugia, Zain Khalil, Harm van Bakel, Derek Smith, Adolfo García-Sastre, Teresa Aydillo
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTSARS-CoV-2 Omicron subvariants are still emerging and spreading worldwide. These variants contain a high number of polymorphisms in the spike (S) glycoprotein that could potentially impact their pathogenicity and transmission. We have previou
Externí odkaz:
https://doaj.org/article/dd636ff1dfcb4a6788fca9dc5eec9110