Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Adolfo Ferrando"'
Autor:
Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Notch1 is frequently activated promoting T-cell acute lymphoblastic leukaemia (T-ALL). Here, the authors show that Notch1 induces oxidative phosphorylation dependency in T-ALL and synergism when inhibiting both mitochondrial complex I and glutaminoly
Externí odkaz:
https://doaj.org/article/3982d909df0b4071b01a6f0797433bde
Autor:
Agnieszka Wendorff, Adolfo Ferrando
Publikováno v:
Bio-Protocol, Vol 10, Iss 10 (2020)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that arises from transformation of T-cell primed hematopoietic progenitors. Although T-ALL is a heterogenous and molecularly complex disease, more than 65% of T-ALL
Externí odkaz:
https://doaj.org/article/40afc9754ce944d7a0fc3715136e8114
Autor:
Pierre Billon, Tarun S. Nambiar, Samuel B. Hayward, Maria P. Zafra, Emma M. Schatoff, Koichi Oshima, Andrew Dunbar, Marco Breinig, Young C. Park, Han S. Ryu, Darjus F. Tschaharganeh, Ross L. Levine, Richard Baer, Adolfo Ferrando, Lukas E. Dow, Alberto Ciccia
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3280-3295.e6 (2020)
Summary: Genome editing technologies have transformed our ability to engineer desired genomic changes within living systems. However, detecting precise genomic modifications often requires sophisticated, expensive, and time-consuming experimental app
Externí odkaz:
https://doaj.org/article/b762df76412f41f19bcbc386580b5456
Autor:
Adolfo Ferrando
Publikováno v:
HemaSphere, Vol 3, Pp 181-183 (2019)
Externí odkaz:
https://doaj.org/article/11aa9b8bd0cc4138b3fa98132230cce0
Autor:
Raajit Rampal, Altuna Alkalin, Jozef Madzo, Aparna Vasanthakumar, Elodie Pronier, Jay Patel, Yushan Li, Jihae Ahn, Omar Abdel-Wahab, Alan Shih, Chao Lu, Patrick S. Ward, Jennifer J. Tsai, Todd Hricik, Valeria Tosello, Jacob E. Tallman, Xinyang Zhao, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, Chuan He, Francois Fuks, Martin S. Tallman, Adolfo Ferrando, Stephen Nimer, Elisabeth Paietta, Craig B. Thompson, Jonathan D. Licht, Christopher E. Mason, Lucy A. Godley, Ari Melnick, Maria E. Figueroa, Ross L. Levine
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1841-1855 (2014)
Summary: Somatic mutations in IDH1/IDH2 and TET2 result in impaired TET2-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The observation that WT1 inactivating mutations anticorrelate with TET2/IDH1/IDH2 mutations in a
Externí odkaz:
https://doaj.org/article/48202f3cd1ec4d1588d2780b05ad48c9
Publikováno v:
Cancer Research. 83:3928-3928
T-cell Acute Lymphoblastic Leukemia (T-ALL) is hematologic tumor characterized by the diffuse infiltration of the bone marrow by malignant hematopoietic cells expressing immature T cell markers. Although T-ALL currently has better cure rates primaril
Autor:
Manuel Torres-Diz, Andrei Thomas-Tikhonenko, Clara Reglero, Adolfo Ferrando, Catherine D Falkenstein, Sarah K Tasian, Priyanka Sehgal, Zhiwei Ang, Yoseph Barash, Caleb Radens
Publikováno v:
Blood. 140:3264-3265
Autor:
Francesca Gianni, Adolfo Ferrando
Publikováno v:
Clinical Management of Acute Lymphoblastic Leukemia ISBN: 9783030851460
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa5f3f0ff76fa00af741023ddccf7fa6
https://doi.org/10.1007/978-3-030-85147-7_2
https://doi.org/10.1007/978-3-030-85147-7_2
Autor:
Daniel Naveed Tavakol, Jessie Brown, Pamela Graney, Teresa Palomero, Adolfo Ferrando, Gordana Vunjak-Novakovic
Publikováno v:
Experimental Hematology. 111:S53
Autor:
Natalia Baran, Alessia Lodi, Shannon Sweeney, Vinitha Mary Kuruvilla, Antonio Cavazos, Anna Skwarska, Sriram Shanmuga Velandy, Karine Harutyunyan, Ningping Feng, Jason Gay, Marcin Kaminski, Elias J. Jabbour, Adolfo Ferrando, M. Emilia Di Francesco, Joseph R. Marszalek, Stefano Tiziani, Marina Konopleva
Publikováno v:
Cancer Research. 78:1875-1875
Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with limited treatment options, largely driven by the activating Notch1 mutations. Oncogenic Notch1 facilitates c-Myc signaling and glutamine oxidation, induces