Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Adolfo Alfonso Pecchio"'
Autor:
Juli R. Bagó, Adolfo Alfonso-Pecchio, Onyi Okolie, Raluca Dumitru, Amanda Rinkenbaugh, Albert S. Baldwin, C. Ryan Miller, Scott T. Magness, Shawn D. Hingtgen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shr
Externí odkaz:
https://doaj.org/article/b167638618f64960906efb2752744934
Autor:
Stephanie A Shumar, Paolo Fagone, Adolfo Alfonso-Pecchio, John T Gray, Jerold E Rehg, Suzanne Jackowski, Roberta Leonardi
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130013 (2015)
Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms
Externí odkaz:
https://doaj.org/article/015a4f62aa274b6580709bbc9c4775a8
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49509 (2012)
The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A (CoA) biosynthesis and regulate the amount of CoA in tissues by differential isoform expression and allosteric interaction with metabolic ligands. The four hu
Externí odkaz:
https://doaj.org/article/414d468a38b04353b36fe36450ed5c30
Autor:
Adolfo Alfonso-Pecchio, Wangfang Hou, Stephen S. Wilson, Quinn Lu, Shu Zhang, Michelle L. Kimberland, Yanhua Rao
Publikováno v:
Journal of Biotechnology. 284:91-101
The CRISPR/Cas9 system has enabled efficient modification of genes in a variety of cellular systems for studying phenotypic effects of genetic perturbations. However, with this technology comes the inherent risk of generating off-target effects (OTEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b471260f5e73a16c8827f81dbfb0b5ab
https://doi.org/10.1016/j.jbiotec.2018.08.007
https://doi.org/10.1016/j.jbiotec.2018.08.007
Autor:
Thomas A. Wynn, Joseph E. Qualls, Charles O. Rock, Luke Barron, Suzanne Jackowski, Geoffrey Neale, Peter J. Murray, Adolfo Alfonso-Pecchio, Lee-Ann Van de Velde, Chitra Subramanian, Amber M. Smith
Publikováno v:
Journal of Biological Chemistry. 292:15-30
Modulation of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of preventing self-reactivity and restoring tissue homeostasis. Consumption of amino acids such as arginine and tryptophan by immunoregulatory ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d755061d7c803c8d73db182d750a39
https://doi.org/10.1074/jbc.m116.766238
https://doi.org/10.1074/jbc.m116.766238
Autor:
Scott T. Magness, C. Ryan Miller, Albert S. Baldwin, Onyi Okolie, Adolfo Alfonso-Pecchio, Juli R. Bagó, Amanda L. Rinkenbaugh, Raluca Dumitru, Shawn Hingtgen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for personalized cell therapy. Here we provide evidence that TD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffffaad402ff2241f7c6ecf586293576
https://doi.org/10.1038/ncomms10593
https://doi.org/10.1038/ncomms10593
Autor:
Jerold E. Rehg, Adolfo Alfonso-Pecchio, Suzanne Jackowski, Paolo Fagone, John T. Gray, Roberta Leonardi, Stephanie A. Shumar
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130013 (2015)
PLoS ONE
PLoS ONE
Background Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (Pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d720410d292706e935e3ab98a9696bf
http://europepmc.org/articles/PMC4460045?pdf=render
http://europepmc.org/articles/PMC4460045?pdf=render
Autor:
Graciela A. Borioli, Beatriz L. Caputto, Germán A. Gil, Mario E. Guido, Adolfo Alfonso Pecchio, D. F. Bussolino, Maximiliano M. Portal, Marianne Renner
Publikováno v:
Molecular Biology of the Cell. 15:1881-1894
We have previously shown that c-Fos activates phospholipid synthesis through a mechanism independent of its genomic AP-1 activity. Herein, using PC12 cells induced to differentiate by nerve growth factor, the genomic effect of c-Fos in initiating neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b434b6024b40396d4a874c933e9c441f
https://doi.org/10.1091/mbc.e03-09-0705
https://doi.org/10.1091/mbc.e03-09-0705
Autor:
Marianne Renner, Adolfo Alfonso Pecchio, María Molina-Calavita, Beatriz L. Caputto, Andrés M. Cardozo Gizzi
Publikováno v:
Molecular Biology of the Cell
c-Fos increases the overall synthesis of polyphosphoinositides by an AP-1–independent mechanism involving activation of CDP-diacylglycerol synthase and phosphatidylinositol (PtdIns) 4-kinase II α but not of PtdIns synthase or PtdIns 4-kinase II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10da8ea02c9874a5f940d3e46f64227
https://pubmed.ncbi.nlm.nih.gov/21998197
https://pubmed.ncbi.nlm.nih.gov/21998197
Publikováno v:
Neuro-Oncology. 16:v79-v79
Transdifferentiation (TD) is an exciting new advancement in somatic cell reprogramming that eliminates the pluripotent intermediate stage to create cells that are ideal for personalized cell transplant therapy. Induced neural stem cells (iNSCs) are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ae6673f87c5f803c56f845ae7ec8c8
https://doi.org/10.1093/neuonc/nou255.2
https://doi.org/10.1093/neuonc/nou255.2