Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Adolf Mistr"'
Autor:
Viktor Horváth, Ales Kroutil, Adolf Mistr, Alois Kozubík, Petr Sova, František Žák, Jiřina Hofmanová, Jaroslav Turánek, Lenka Svihálková-Sindlerová, Karel Souček
Publikováno v:
Biochemical Pharmacology. 69:373-383
[(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)], coded as LA-12, is an octahedral platinum(IV) complex containing a bulky hydrophobic ligand - adamantylamine. The use of bulky hydrophobic amines as non-leaving ligands, may increa
Autor:
Ales Kroutil, Adolf Mistr, Petr Sova, Jaroslav Chládek, Zdenek Slovak, Martin Semerad, Frantisek Zak
Publikováno v:
International Journal of Pharmaceutics. 288:123-129
The pharmacokinetics of total and free plasma platinum (Pt) and Pt tissue distribution were investigated in rats after oral administration of (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) (LA-12). Plasma and ultrafiltrate were sa
Autor:
Ales Kroutil, Adolf Mistr, Petr Sova, Veronika Kvardová, Pavlína Turánek Knotigová, Jiří Neča, Lenka Šindlerová, Alois Kozubík, Viktor Horváth, Andrea Kašná, Dana Záluská, František Žák, Jaroslav Turánek
Publikováno v:
Anti-Cancer Drugs. 15:537-543
The aim of this study was to compare anti-tumor potency of platinum(IV) complexes with increasing hydrophobicity of their ligands. Cytotoxic potential of the new platinum(IV) complex, coded as LA-12 [(OC-6-43)-bis(acetato)(1-adamantylamine)amminedich
Autor:
Frantisek Zak, Alois Kozubík, Zdirad Zák, Andrea Kašná, Jaroslav Turánek, Anna Poulova, Lenka Šindlerová, Jiri Neca, Ales Kroutil, Adolf Mistr, Petr Sova, Dana Záluská, Petr Mikolin
Publikováno v:
Journal of Medicinal Chemistry. 47:761-763
Procedure of the synthesis is described for new platinum(IV) drug LA-12 [(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement
Publikováno v:
Anti-cancer drugs. 17(2)
The oral anti-tumor activity of a novel platinum(IV) complex, coded as LA-12, with a bulky adamantylamine ligand was evaluated and compared with another platinum(IV) complex satraplatin. The human carcinoma xenografts of colon HCT116, prostate PC3, a
Publikováno v:
Anti-Cancer Drugs; Jul2005, Vol. 16 Issue 6, p653-657, 5p
Publikováno v:
Collection of Czechoslovak Chemical Communications. 43:739-745