Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Adnane Aouidate"'
Autor:
Abdelmoujoud Faris, Ivana Cacciatore, Radwan Alnajjar, Adnane Aouidate, Mohammed H. AL Mughram, Menana Elhallaoui
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The Janus kinase 3 (JAK3) family, particularly JAK3, is pivotal in initiating autoimmune diseases such as rheumatoid arthritis. Recent advancements have focused on developing antirheumatic drugs targeting JAK3, leading to the discovery of novel pyraz
Externí odkaz:
https://doaj.org/article/d48cbf8cb96f4e7e98a86152d89af184
Autor:
Abdelmoujoud Faris, Ivana Cacciatore, Radwan Alnajjar, Hadni Hanine, Adnane Aouidate, Ramzi A. Mothana, Abdullah R. Alanzi, Menana Elhallaoui
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The heterocycle compounds, with their diverse functionalities, are particularly effective in inhibiting Janus kinases (JAKs). Therefore, it is crucial to identify the correlation between their complex structures and biological activities for the deve
Externí odkaz:
https://doaj.org/article/a92838db09a44b7b80f83538be346eba
Autor:
Abdelmoujoud Faris, Radwan Alnajjar, Jingjing Guo, Mohammed H. AL Mughram, Adnane Aouidate, Mufarreh Asmari, Menana Elhallaoui
Publikováno v:
Molecules, Vol 29, Iss 1, p 23 (2023)
This work aimed to find new inhibitors of the CYP3A4 and JAK3 enzymes, which are significant players in autoimmune diseases such as rheumatoid arthritis. Advanced computer-aided drug design techniques, such as pharmacophore and 3D-QSAR modeling, were
Externí odkaz:
https://doaj.org/article/b62d12261ed54b84a571e61c0f8aa3b9
Autor:
Mohammed Barbouchi, Bouchra Benzidia, Adnane Aouidate, Adib Ghaleb, Mostafa El Idrissi, M'barek Choukrad
Publikováno v:
Journal of King Saud University: Science, Vol 32, Iss 7, Pp 2995-3004 (2020)
In this study, essential oils (EOs) obtained from twigs, leaves and fruits of Terebinth (Pistacia terebinthus L.) was characterized by GC/MS analysis. We tested these as green corrosion inhibitors for iron in the neutral chloride medium (3% NaCl), em
Externí odkaz:
https://doaj.org/article/612aed10831d4ac6bff943b647e5460f
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 7, Pp 6236-6245 (2020)
Novel N-acylhydrazone derivatives from acridone have been synthesized by condensation of acridone acetohydrazide and various aldehyde. The novel acylhydrazones were tested for their in-vitro antibacterial activity against human pathogenic strains. Th
Externí odkaz:
https://doaj.org/article/a77d170be7a549a49cb4cdea0fdc9b37
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 9, Iss 1, Pp 84-92 (2019)
Purpose: In this review, a set of aryl halides analogs were identified as potent checkpoint kinase1 (Chk1) inhibitors through a series of computer-aided drug design processes, to develop modelswith good predictive ability, highlight the important int
Externí odkaz:
https://doaj.org/article/c59993606459411e9ae17824d96f5e68
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
New drug discovery has been acknowledged as a complicated, expensive, time-consuming, and challenging project. It has been estimated that around 12 years and 2.7 billion USD, on average, are demanded for a new drug discovery via traditional drug deve
Externí odkaz:
https://doaj.org/article/1572d551a2b7437bb03f341d061b5bf8
Autor:
Adib Ghaleb, Adnane Aouidate, Abdelouahid Sbai, Tahar Lakhlifi, Hamid Maghat, Mouhamed Bouachrine
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 9, Iss 5, Pp 337-343 (2017)
A theoretical study of 1,3-cycloaddition has been carried out using density functional theory (DFT) methods at the B3LYP/6-31G* level. The regioselectivity of the reaction have been clarified through different theoretical approaches: Case of a Two-Ce
Externí odkaz:
https://doaj.org/article/1c57a18b89284aa7854c7d05284492c7
Autor:
Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017)
Abstract Background Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM1 and PIM2 inhibitors
Externí odkaz:
https://doaj.org/article/47ae367aa30840b08d531fb8afe3bb06
Autor:
Samir Chtita, Mounir Ghamali, Abdellah Ousaa, Adnane Aouidate, Assia Belhassan, Abdelali Idrissi Taourati, Vijay Hariram Masand, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Heliyon, Vol 5, Iss 3, Pp e01304- (2019)
The quantitative structure-activity relationship (QSAR) of sixty 2-phenylimidazopyridines derivatives with anti-Human African Trypanosomiasis (anti-HAT) activity has been studied by using the density functional theory (DFT) and statistical methods. B
Externí odkaz:
https://doaj.org/article/e7992726e31d4951b1e9b565231d1b9f