Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Adnan R. Munkarah"'
Autor:
Mary P. Udumula, Laila M. Poisson, Indrani Dutta, Nivedita Tiwari, Seongho Kim, Jasdeep Chinna-Shankar, Ghassan Allo, Sharif Sakr, Miriana Hijaz, Adnan R. Munkarah, Shailendra Giri, Ramandeep Rattan
Publikováno v:
Cancers, Vol 14, Iss 6, p 1504 (2022)
Metformin is being actively repurposed for the treatment of gynecologic malignancies including ovarian cancer. We investigated if metformin induces analogous metabolic changes across ovarian cancer cells. Functional metabolic analysis showed metformi
Externí odkaz:
https://doaj.org/article/2fa7f431f0c64c23ba91e6aa070a0dd3
Autor:
Ludmila Kaplun, Aviva Levine Fridman, Wei Chen, Nancy K. Levin, Sidra Ahsan, Nancie Petrucelli, Jennifer L. Barrick, Robin Gold, Susan Land, Michael S. Simon, Robert T. Morris, Adnan R. Munkarah, Michael A. Tainsky
Publikováno v:
Biomarker Insights, Vol 2012, Iss 7, Pp 151-157 (2012)
Externí odkaz:
https://doaj.org/article/fc5b4fcbf2254443ac74e1adb10ea0e8
Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer
Autor:
Luisa Manning, Bradley J. Monk, Phylicia Aaron, Evanthia Galanis, Staci Horvath, Rodney P. Rocconi, Thomas J. Herzog, Erin E. Stevens, Adnan R. Munkarah, Meghan Manley, Sharad A. Ghamande, Justin N. Bottsford-Miller, Gladice Wallraven, John Nemunaitis, Adam Walter, Robert L. Coleman, Jeffrey Elder, Leslie L. DeMars, Laura Stanbery, Ernest Bognar
Publikováno v:
Cancer Gene Therapy. 29:369-382
Vigil® is a personalized vaccine that enhances tumor neoantigen expression. We investigated for the first time safety and efficacy of Vigil in combination with atezolizumab in relapsed ovarian cancer (OC) patients. This is a randomized, Phase 1 stud
Autor:
Shuang Wei, Yingjie Bian, Xiong Li, Weichao Wang, Weiping Zou, Shasha Li, Adnan R. Munkarah, J. Rebecca Liu, Ilona Kryczek, Weimin Wang, Linda Vatan, Houjun Xia, Jun-Lin Guan, Karen McLean, Ramandeep Rattan, Sara Grove
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 18 (2020)
JCI Insight, Vol 5, Iss 18 (2020)
Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian carcinoma often metastasizes to the peritoneal cavity. Here, we found 2 peritoneal macrophage subsets in mice bearing ID8 ovarian cancer based on T cell immunoglobulin
Autor:
Ismail Mert, Shailendra Giri, Marta Llauradó, Jing Dai, Shelly Seward, Ramandeep Rattan, Jasdeep Chhina, Ghassan Allo, Mark S. Carey, Adnan R. Munkarah
Publikováno v:
Gynecologic Oncology. 146:319-326
Objective Low-grade serous ovarian cancer (LGSOC) constitutes 5–8% of epithelial ovarian cancers and is refractory to chemotherapy. We and others have shown metformin to cause significant growth inhibition in high-grade ovarian cancer both in vitro
Publikováno v:
Brachytherapy. 16:841-846
Purpose Adjuvant treatment in early stage uterine serous carcinoma (USC) usually consists of chemotherapy with vaginal brachytherapy (VB), pelvic external beam radiation therapy (EBRT), or combination. We compared survival outcomes across these vario
Autor:
Carolyn Johnston, Melissa K. Zochowski, Hope K. Haefner, Ira Winer, Robert T. Morris, Elisabeth H. Quint, Divya Patel, Vanessa K. Dalton, Adnan R. Munkarah
Publikováno v:
International Journal of Gynecology & Obstetrics. 138:177-182
Objective To investigate the provision of care for pediatric and adolescent patients by gynecologic oncologists. Methods The present prospective cross-sectional study enrolled attending physicians and fellows specializing in gynecologic oncology from
Autor:
Ismail Mert, Sajad Ahmad Dar, Jasdeep Chhina, Rouba Ali-Fehmi, Adnan R. Munkarah, Thomas E. Buekers, M. Taylor, Miriana Hijaz, Ramandeep Rattan, Z. Al-Wahab
Publikováno v:
Gynecologic Oncology. 142:323-331
BRCA mutated ovarian cancers show increased responsiveness to PARP inhibitors. PARP inhibitors target DNA repair and provide a second hit to BRCA mutated tumors, resulting in "synthetic lethality". We investigated a combination of metformin and olapa
Autor:
Adnan R. Munkarah, Jasdeep Chhina, Ismail Mert, Shailendra Giri, S. Hensley Alford, Ramandeep Rattan, Suhail Hamid, Miriana Hijaz, Laila M. Poisson
Publikováno v:
Gynecologic Oncology. 141:72-79
Objectives Adipocyte derived free fatty acids (FFA) promote epithelial ovarian cancer (EOC) by acting as a fuel source to support the energy requirement of the cancer cells. FFA may also exert biological effects through signaling pathways. Recently,
Autor:
Vaishnavi Raja, Thomas E. Buekers, Shailendra Giri, Suhail Hamid, Ramandeep Rattan, Adnan R. Munkarah
Publikováno v:
Clinical Cancer Research. 26:A69-A69
Signal Transducers and Activators of Transcription 3 (STAT3) is a transcription factor that is known to play a key role in cancer progression. In ovarian cancer, STAT3 overexpression leads to increased cancer cell proliferation and confers resistance