Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Adnan O. Abu-Yousif"'
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Eshita Khera, Cornelius Cilliers, Michael D. Smith, Michelle L. Ganno, Katharine C. Lai, Thomas A. Keating, Anna Kopp, Ian Nessler, Adnan O. Abu-Yousif, Greg M. Thurber
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://doaj.org/article/a1d49a829b1446a5941d3e371fc652ef
Autor:
Elizabeth Carideo Cunniff, Yosuke Sato, Doanh Mai, Vicky A. Appleman, Shinji Iwasaki, Vihren Kolev, Atsushi Matsuda, Judy Shi, Michiyo Mochizuki, Masato Yoshikawa, Jian Huang, Luhua Shen, Satyajeet Haridas, Vaishali Shinde, Chris Gemski, Emily R. Roberts, Omid Ghasemi, Hojjat Bazzazi, Saurabh Menon, Tary Traore, Pu Shi, Tennille D. Thelen, Joseph Conlon, Adnan O. Abu-Yousif, Christopher Arendt, Michael H. Shaw, Masanori Okaniwa
Publikováno v:
Cancer Research Communications. 2:489-502
Oncology therapies targeting the immune system have improved patient outcomes across a wide range of tumor types, but resistance due to an inadequate T-cell response in a suppressive tumor microenvironment (TME) remains a significant problem. New the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f15976fac4916e2a443db60d3b3b36d
https://doi.org/10.1158/2767-9764.crc-21-0161
https://doi.org/10.1158/2767-9764.crc-21-0161
Autor:
David A. Barbie, Raphael Bueno, Cloud P. Paweletz, Rizwan Romee, Michael Y. Tolstorukov, Juan J. Miret, Pasi A. Jänne, Eric L. Smith, Neil Lineberry, Alexander Parent, Richard C. Gregory, Vicky A. Appleman, Adnan O. Abu-Yousif, William G. Richards, Assunta De Rienzo, Marina Vivero, Israel Cañadas, Ze-Hua Li, Pinar O. Eser, Antja-Voy Hartley, Thomas P. Albertson, Timothy J. Haggerty, Kartika Venugopal, Corinne E. Gustafson, Tran C. Thai, Saemi Han, Arrien A. Bertram, Minh Ha, Ha V. Vo, Ari Zlota, Anna M. Lee-Hassett, Pieter J. Schol, Tetsuo Tani, Navin R. Mahadevan, Erin Shannon, Cameron M. Messier, Bonje Obua, Nathaniel Spicer, Brandon Piel, Minyue Chen, Brittany Meisenheimer, Moataz Noureddine, Ismail Ozgenc, Matthew A. Booker, Patrick H. Lizotte, Marco Campisi, Mubin Tarannum, Elena V. Ivanova, Erik H. Knelson
Activation of the stimulator of interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding of the mechanism of action of STING agonists in human tumors is key to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34335b05bd2da45a66fc885095d546f7
https://doi.org/10.1158/2326-6066.c.6550907
https://doi.org/10.1158/2326-6066.c.6550907
Autor:
Masanori Okaniwa, Michael H. Shaw, Christopher Arendt, Adnan O. Abu-Yousif, Joseph Conlon, Tennille D. Thelen, Pu Shi, Tary Traore, Saurabh Menon, Hojjat Bazzazi, Omid Ghasemi, Emily R. Roberts, Chris Gemski, Vaishali Shinde, Satyajeet Haridas, Luhua Shen, Jian Huang, Masato Yoshikawa, Michiyo Mochizuki, Judy Shi, Atsushi Matsuda, Vihren Kolev, Shinji Iwasaki, Vicky A. Appleman, Doanh Mai, Yosuke Sato, Elizabeth Carideo Cunniff
Supplementary methods and results: The supplementary methods describe: 1) the chemical synthesis and characterization of TAK-676, inclusive of TAK-676 chemical structure, purification chromatogram and NMR characterization; 2) details regarding STING
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931bb15e27a36d43a39bd54192992a77
https://doi.org/10.1158/2767-9764.22544573
https://doi.org/10.1158/2767-9764.22544573
Autor:
Masanori Okaniwa, Michael H. Shaw, Christopher Arendt, Adnan O. Abu-Yousif, Joseph Conlon, Tennille D. Thelen, Pu Shi, Tary Traore, Saurabh Menon, Hojjat Bazzazi, Omid Ghasemi, Emily R. Roberts, Chris Gemski, Vaishali Shinde, Satyajeet Haridas, Luhua Shen, Jian Huang, Masato Yoshikawa, Michiyo Mochizuki, Judy Shi, Atsushi Matsuda, Vihren Kolev, Shinji Iwasaki, Vicky A. Appleman, Doanh Mai, Yosuke Sato, Elizabeth Carideo Cunniff
Oncology therapies targeting the immune system have improved patient outcomes across a wide range of tumor types, but resistance due to an inadequate T-cell response in a suppressive tumor microenvironment (TME) remains a significant problem. New the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba8980eb34badc6a19f61bbce026e67
https://doi.org/10.1158/2767-9764.c.6550691
https://doi.org/10.1158/2767-9764.c.6550691
Autor:
Masanori Okaniwa, Michael H. Shaw, Christopher Arendt, Adnan O. Abu-Yousif, Joseph Conlon, Tennille D. Thelen, Pu Shi, Tary Traore, Saurabh Menon, Hojjat Bazzazi, Omid Ghasemi, Emily R. Roberts, Chris Gemski, Vaishali Shinde, Satyajeet Haridas, Luhua Shen, Jian Huang, Masato Yoshikawa, Michiyo Mochizuki, Judy Shi, Atsushi Matsuda, Vihren Kolev, Shinji Iwasaki, Vicky A. Appleman, Doanh Mai, Yosuke Sato, Elizabeth Carideo Cunniff
Supplementary tables: Supplementary Table 1 describes where cells were obtained from and details of authentication and mycoplasma testing dates. Supplementary Table 2 shows TAK-676 potency in cynomolgus monkey, human, mouse, and rat STING via time-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc816185704d6e9271927a182bdb34f
https://doi.org/10.1158/2767-9764.22544570
https://doi.org/10.1158/2767-9764.22544570
Autor:
Masanori Okaniwa, Michael H. Shaw, Christopher Arendt, Adnan O. Abu-Yousif, Joseph Conlon, Tennille D. Thelen, Pu Shi, Tary Traore, Saurabh Menon, Hojjat Bazzazi, Omid Ghasemi, Emily R. Roberts, Chris Gemski, Vaishali Shinde, Satyajeet Haridas, Luhua Shen, Jian Huang, Masato Yoshikawa, Michiyo Mochizuki, Judy Shi, Atsushi Matsuda, Vihren Kolev, Shinji Iwasaki, Vicky A. Appleman, Doanh Mai, Yosuke Sato, Elizabeth Carideo Cunniff
Supplementary figures: Supplementary Figure 1 shows cell viability of human monocyte-derived dendric cells and mouse bone marrow dendritic cells. Supplementary Figure 2 shows mean plasma and tumor concentration-time curves of TAK-676 in BALB/C mice (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f557c397f065d58fee34ecc2828d809
https://doi.org/10.1158/2767-9764.22544576
https://doi.org/10.1158/2767-9764.22544576
Autor:
David A. Barbie, Raphael Bueno, Cloud P. Paweletz, Rizwan Romee, Michael Y. Tolstorukov, Juan J. Miret, Pasi A. Jänne, Eric L. Smith, Neil Lineberry, Alexander Parent, Richard C. Gregory, Vicky A. Appleman, Adnan O. Abu-Yousif, William G. Richards, Assunta De Rienzo, Marina Vivero, Israel Cañadas, Ze-Hua Li, Pinar O. Eser, Antja-Voy Hartley, Thomas P. Albertson, Timothy J. Haggerty, Kartika Venugopal, Corinne E. Gustafson, Tran C. Thai, Saemi Han, Arrien A. Bertram, Minh Ha, Ha V. Vo, Ari Zlota, Anna M. Lee-Hassett, Pieter J. Schol, Tetsuo Tani, Navin R. Mahadevan, Erin Shannon, Cameron M. Messier, Bonje Obua, Nathaniel Spicer, Brandon Piel, Minyue Chen, Brittany Meisenheimer, Moataz Noureddine, Ismail Ozgenc, Matthew A. Booker, Patrick H. Lizotte, Marco Campisi, Mubin Tarannum, Elena V. Ivanova, Erik H. Knelson
Supplementary Data from Activation of Tumor-Cell STING Primes NK-Cell Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5f553fda34db80adc5399773dc6ed3
https://doi.org/10.1158/2326-6066.22545320.v1
https://doi.org/10.1158/2326-6066.22545320.v1
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d56b0bf0e605a39ee70fc897c8b59
https://doi.org/10.1158/1535-7163.c.6542328.v1
https://doi.org/10.1158/1535-7163.c.6542328.v1
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Supplemental Figure 1: heavy and light chain sequences for 5F9, the human IgG1 monoclonal antibody (mAb) targeting the extracellular domain of GCC as described previously Supplemental Figure 2: Characterization of TAK-164 and chKTI-DGN549 by A) SDS P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc671e1a3ed72f6591ec22f46838181
https://doi.org/10.1158/1535-7163.22519161.v1
https://doi.org/10.1158/1535-7163.22519161.v1