Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Adnan Avdic-Belltheus"'
Autor:
Nicola J. Robertson, Kathryn Martinello, Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Daniel Alonso-Alconada, Sara Ragab, Alan Bainbridge, Magdalena Sokolska, Mohamed Tachrount, Benita Middleton, David Price, Mariya Hristova, Xavier Golay, Annamaria Soliani Raschini, Giancarlo Aquino, Nicola Pelizzi, Fabrizio Facchinetti
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 240-251 (2019)
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (
Externí odkaz:
https://doaj.org/article/7daf6abf1444477d8d26b24a12891d49
Autor:
Raymand Pang, Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Magda Sokolska, Tatenda Mutshiya, Alan Bainbridge, Xavier Golay, Nicola J. Robertson
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Despite therapeutic hypothermia, survivors of neonatal encephalopathy have high rates of adverse outcome. Early surrogate outcome measures are needed to speed up the translation of neuroprotection trials. Thalamic lactate (Lac)/N-acetylaspartate (NAA
Externí odkaz:
https://doaj.org/article/cb3c1094922b43c5b22938f1f1897e34
Autor:
Cally J Tann, Henrik Hagberg, Christopher Meehan, Xavier Golay, Nigel Klein, Boris W. Kramer, Adnan Avdic-Belltheus, Tim G. A. M. Wolfs, Ingran Lingam, Kathryn A. Martinello, Pierre Gressens, Melinda Barkhuizen, Sara Ragab, Donald Peebles, Nicola J. Robertson, Bobbi Fleiss, Ilias Tachtsidis
Publikováno v:
Pediatric Research, 89(3), 464-475. Nature Publishing Group
BACKGROUND: Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hy
Autor:
Ilias Tachtsidis, Frederic Lange, Paola Pinti, Gemma Bale, Magdalena Sokolska, Adnan Avdic-Belltheus, Christopher Meehan, Nicola Robertson, Shahrzad Parsa, Udo Weigel, Turgut Durduran, Subhrabrata Mitra
Publikováno v:
Diffuse Optical Spectroscopy and Imaging VIII.
Autor:
Xavier Golay, Nigel Klein, Ingran Lingam, Alan Bainbridge, Nicola J. Robertson, Tim G. A. M. Wolfs, Kathryn A. Martinello, Qin Yang, Tatenda Mutshiya, Magdalena Sokolska, Ilias Tachtsidis, Mariya Hristova, Donald Peebles, Henrik Hagberg, Christopher Meehan, Pierre Gressens, Bobbi Fleiss, Boris W. Kramer, David Price, Adnan Avdic-Belltheus, Mustafa Ali Akin, Cally J Tann
Publikováno v:
Martinello, K A, Meehan, C, Avdic-belltheus, A, Lingam, I, Mutshiya, T, Yang, Q, Akin, M A, Price, D, Sokolska, M, Bainbridge, A, Hristova, M, Tachtsidis, I, Tann, C J, Peebles, D, Hagberg, H, Wolfs, T G A M, Klein, N, Kramer, B W, Fleiss, B, Gressens, P, Golay, X & Robertson, N J 2021, ' Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia–ischemia ', Pediatric Research . https://doi.org/10.1038/s41390-021-01584-6
Pediatric Research, 91(6), 1416-1427. Nature Publishing Group
Pediatric Research
Pediatric Research, 91(6), 1416-1427. Nature Publishing Group
Pediatric Research
Background Perinatal inflammation combined with hypoxia–ischemia (HI) exacerbates injury in the developing brain. Therapeutic hypothermia (HT) is standard care for neonatal encephalopathy; however, its benefit in inflammation-sensitized HI (IS-HI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d874981992f71532f6a059f12b3d27e
https://www.pure.ed.ac.uk/ws/files/213744722/41390_2021_Article_1584.pdf
https://www.pure.ed.ac.uk/ws/files/213744722/41390_2021_Article_1584.pdf
Autor:
Nicola J. Robertson, Ingran Lingam, Pardis Kaynezhad, Cornelius Bauer, Mariya Hristova, Kathryn A. Martinello, Ilias Tachtsidis, Adnan Avdic-Belltheus, Chris Meehan, Xavier Golay
Publikováno v:
Pediatric Research. 86:699-708
Neuroprotection from therapeutic hypothermia (HT) is incomplete, therefore additional strategies are necessary to improve long-term outcomes. We assessed the neuroprotective efficacy of magnesium sulfate (MgSO4) bolus and infusion over 48 h plus HT i
Autor:
Ingran Lingam, Cornelius Bauer, Gemma Bale, Adnan Avdic-Belltheus, Ilias Tachtsidis, Kathryn A. Martinello, Pardis Kaynezhad, Joshua Russell-Buckland, Alan Bainbridge, Christopher Meehan, Subhabrata Mitra, Nicola J. Robertson
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030482367
Hypoxic ischaemic encephalopathy (HIE) is a significant cause of death and disability. Therapeutic hypothermia (TH) is the only available standard of treatment, but 45–55% of cases still result in death or neurodevelopmental disability following TH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43d450001dbd7630b241b0e304d25fc
https://doi.org/10.1007/978-3-030-48238-1_5
https://doi.org/10.1007/978-3-030-48238-1_5
Autor:
Raymand Pang, Nicola J. Robertson, Tatenda Mutshiya, Xavier Golay, Kathryn A. Martinello, Qin Yang, Christopher Meehan, F. J. Torrealdea, Mariya Hristova, Alan Bainbridge, Adnan Avdic-Belltheus, Sandra E. Juul, Magdalena Sokolska
Publikováno v:
Brain Communications
As therapeutic hypothermia is only partially protective for neonatal encephalopathy, safe and effective adjunct therapies are urgently needed. Melatonin and erythropoietin show promise as safe and effective neuroprotective therapies. We hypothesized
Autor:
Alan Bainbridge, Adnan Avdic-Belltheus, Kathryn A. Martinello, Magda Sokolska, Tatenda Mutshiya, Ingran Lingam, Christopher Meehan, Xavier Golay, Raymand Pang, Nicola J. Robertson
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Despite therapeutic hypothermia, survivors of neonatal encephalopathy have high rates of adverse outcome. Early surrogate outcome measures are needed to speed up the translation of neuroprotection trials. Thalamic lactate (Lac)/N-acetylaspartate (NAA
Autor:
Xenia Charalambous, Tatenda Mutshiya, Kathryn A. Martinello, B. Weil, Mariya Hristova, Boris W. Kramer, Ingran Lingam, Mark W. Lowdell, Tiziana Boggini, Qin Yang, Nicola J. Robertson, Adnan Avdic-Belltheus, Alan Bainbridge, Christopher Meehan, Magdalena Sokolska, Xavier Golay
Publikováno v:
Cytotherapy
Cytotherapy, 23(6), 521-535. ELSEVIER SCI LTD
Cytotherapy, 23(6), 521-535. ELSEVIER SCI LTD
Background: With therapeutic hypothermia (HT) for neonatal encephalopathy, disability rates are reduced, but not all babies benefit. Pre-clinical rodent studies suggest mesenchymal stromal cells (MSCs) augment HT protection. Aims: The authors studied