Predicting the risk of chest radiograph abnormality 12-weeks post hospitalisation with SARS CoV-2 PCR confirmed COVID-19

Autor: Tim JM Wallis, Benjamin Welham, Alex Kong, Tommaso Morelli, Adnan Azim, Jose Horno, Miranda Wilkinson, Hannah Burke, Anna Freeman, Thomas MA Wilkinson, Mark G Jones, Benjamin G Marshall

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-7 (2022)

Abstract Background Routine follow-up of patients hospitalised with COVID-19 is recommended, however due to the ongoing high number of infections this is not without significant health resource and economic burden. In a previous study we investigated

Externí odkaz: https://doaj.org/article/ae7e9c66437e41fbac34f395445ddbd4

Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic

Autor: Adnan Azim, Heena Mistry, Anna Freeman, Clair Barber, Colin Newell, Kerry Gove, Yvette Thirlwall, Matt Harvey, Kimberley Bentley, Deborah Knight, Karen Long, Frances Mitchell, Yueqing Cheng, Judit Varkonyi-Sepp, Wolfgang Grabau, Paddy Dennison, Hans Michael Haitchi, S. Hasan Arshad, Ratko Djukanovic, Tom Wilkinson, Peter Howarth, Ramesh J. Kurukulaaratchy

Publikováno v: BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-11 (2019)

Abstract Background Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a

Externí odkaz: https://doaj.org/article/6f0e734243314ef0a96b91c6660ed495

Comprehensive characterisation of difficult-to-treat asthma reveals near absence of T2-low status

Autor: Hitasha Rupani, Mohammed Aref Kyyaly, Adnan Azim, Rana Abadalkareen, Anna Freeman, Paddy Dennison, Peter Howarth, Ratko Djukanovic, Pandurangan Vijayanand, Gregory Seumois, S Hasan Arshad, Hans Michael Haitchi, Ramesh J. Kurukulaaratchy

Background: asthma is conventionally stratified as type 2-inflammation (T2) high or T2-low disease. Identifying T2-status has therapeutic implications for patient management but real-world understanding of this T2 paradigm in difficult-to-treat/ seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0235460390491a0e05a568e1a9a71cbe
https://eprints.soton.ac.uk/477586/

Peripheral airways type 2 inflammation, neutrophilia and microbial dysbiosis in severe asthma

Autor: Peter H. Howarth, Adnan Azim, Nivenka Jayasekera, Ben Green, Hitasha Rupani, Kenneth D. Bruce, Laurie Lau

Publikováno v: Allergy. 76:2070-2078

Background: IL-13 is considered an archetypal T2 cytokine central to the clinical disease expression of asthma. The IL-13 response genes, which are upregulated in central airway bronchial epithelial of asthma patients, can be normalized by high-dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34eedb39768aab35bf17b3a5692d04ac
https://doi.org/10.1111/all.14732

Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum

Autor: Clair Barber, Adnan Azim, Colin Newell, Aref Kyyaly, Hitasha Rupani, Hans Michael Haitchi, Peter Howarth, Ramesh Kurukulaaratchy

Publikováno v: Barber, C, Azim, A, Newell, C, Kyyaly, A, Rupani, H, Haitchi, H M, Howarth, P & Kurukulaaratchy, R J 2022, ' Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum ', Clinical and Experimental Allergy, vol. 52, no. 6, pp. 792-796 . https://doi.org/10.1111/cea.14109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beab597d0017c7068b2b3ed4fbf9f955
https://eprints.soton.ac.uk/455758/