Výsledky vyhledávání

Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

Autor: Hamit Emre Kızıl, Cuneyt Caglayan, Ekrem Darendelioğlu, Adnan Ayna, Cihan Gür, Fatih Mehmet Kandemir, Sefa Küçükler

Publikováno v: Molecular Biology Reports. 50:3479-3488

Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91872d9b8121bc98f9249569b8a12301
https://doi.org/10.1007/s11033-023-08286-8

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Akademický článek

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Autor: Gokhan Zengin, Mohamad Fawzi Mahomoodally, Abdurrahman Aktumsek, József Jekő, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Rıdvan Polat, Ugur Cakilcioglu, Adnan Ayna, Monica Gallo, Domenico Montesano, Carene Picot-Allain

Publikováno v: Plants, Vol 10, Iss 6, p 1176 (2021)

Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and

Externí odkaz: https://doaj.org/article/33da55aad4b647248683d073fe3d8fc9

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Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway

Autor: Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Cihan Gür, Sefa Küçükler, Ekrem Darendelioğlu

Publikováno v: Metabolic Brain Disease. 37:1931-1940

The exposure to bisphenol A (BPA) is inevitable owing to its common use in the production of polycarbonate plastics. Studies to reduce side effects are gaining importance since BPA causes severe toxicities in important tissues such as testes, lungs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98b5490f7deca27db197ddbc1722b77
https://doi.org/10.1007/s11011-022-01027-z

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Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

Autor: Hamit Emre Kızıl, Cuneyt Caglayan, Ekrem Darendelioğlu, Adnan Ayna, Cihan Gür, Fatih Mehmet Kandemir, sefa Küçükler

Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da95d1f4e6317dc99889a74012fc2c5
https://doi.org/10.21203/rs.3.rs-1970940/v1

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Caffeic acid prevents hydrogen peroxide-induced oxidative damage in SH-SY5Y cell line through mitigation of oxidative stress and apoptosis

Autor: Adnan Ayna

Publikováno v: Bratislava Medical Journal. 122:120-124

Aim The aim of this study was to examine the potential ameliorative effects of caffeic acid (CA) on hydrogen peroxide (H2O2)-induced neurodegeneration in a human SH-SY5Y cell line, as well as possible mechanisms involved. Method Cell proliferation wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514a3c7dc7f877bdebda3d2fcaab9f51
https://doi.org/10.4149/bll_2021_018

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Synthesis of a Novel Supermagnetic Fe3O4 Nanoparticles and their Congo Red Dye Removal, Cytotoxic, Antioxidant, and Antimicrobial Activities

Autor: Semih GÖKDAĞ, Fatma CAF, Fulya DOĞANER, BÜLENT KAYA, Adnan AYNA, Gürkan AYKUTOĞLU

Biogenic synthesis of iron nanoparticles has been reported in many studies. However, there is no such study that combines antioxidant, antimicrobial, anticancer and dye removal activities of the synthesized iron nanoparticles. The present study focus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41af40f78a3ee57d53a3ce240b3e475a
https://doi.org/10.21203/rs.3.rs-1458659/v1

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Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells

Autor: Gökhan Dervişoğlu, Ekrem Darendelioğlu, Gürkan Aykutoğlu, Adnan Ayna, BÜLENT KAYA

Green synthesis of silver nanoparticles (AgNPs) has been reported in several studies. However, no study focused on synthesis, characterization, and investigation of anticancer and antioxidant activities of AgNPs using Bingöl propolis. The morphology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1d9980ac6a08d8ce4cb0771ad7941f7
https://doi.org/10.21203/rs.3.rs-1454565/v1

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