Evaluating tools for live imaging of structural plasticity at the axon initial segment

Autor: Adna S Dumitrescu, Mark D Evans, Matthew S Grubb

Publikováno v: Frontiers in Cellular Neuroscience, Vol 10 (2016)

The axon initial segment (AIS) is a specialised neuronal compartment involved in the maintenance of axo-dendritic polarity and in the generation of action potentials. It is also a site of significant structural plasticity – manipulations of neurona

Externí odkaz: https://doaj.org/article/9ba1a217ca9042bb8e0bdefb5d63109a

Myosin II activity is required for structural plasticity at the axon initial segment

Autor: Mark D, Evans, Candida, Tufo, Adna S, Dumitrescu, Matthew S, Grubb

Publikováno v: The European journal of neuroscience. 46(2)

In neurons, axons possess a molecularly defined and highly organised proximal region - the axon initial segment (AIS) - that is a key regulator of both electrical excitability and cellular polarity. Despite existing as a large, dense structure with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b36aa6cb75e9a5c6d060eef711895723
https://pubmed.ncbi.nlm.nih.gov/28612392

Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment

Autor: Rosanna P. Sammons, Matthew S. Grubb, Sabrina Lebron, Mark D. Evans, John J. Renger, Thomas B.K. Watkins, Victor N. Uebele, Adna S. Dumitrescu

Publikováno v: The Journal of Neuroscience. 33:6950-6963

The axon initial segment (AIS) is a specialized neuronal subcompartment located at the beginning of the axon that is crucially involved in both the generation of action potentials and the regulation of neuronal polarity. We recently showed that prolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a01a12d92f244600092dab7ef31531
https://doi.org/10.1523/jneurosci.0277-13.2013

Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing

Autor: Mark D. Evans, Adna S. Dumitrescu, Dennis L.H. Kruijssen, Samuel E. Taylor, Matthew S. Grubb

Publikováno v: Evans, M D, Dumitrescu, A S, Kruijssen, D L H, Taylor, S E & Grubb, M S 2015, ' Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing ', Cell Reports, vol. 13, no. 6, pp. 1233-1245 . https://doi.org/10.1016/j.celrep.2015.09.066
Cell Reports, Vol 13, Iss 6, Pp 1233-1245 (2015)

Neurons implement a variety of plasticity mechanisms to alter their function over timescales ranging from seconds to days. One powerful means of controlling excitability is to directly modulate the site of spike initiation, the axon initial segment (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d8210497f32a5f20120592f910d96b48