Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function

Autor: Nicholas P. Schafer, Riyaz A. Mir, Jeff Lovelace, Peter D. Simone, Admir Kellezi, Carol Kolar, Gaelle Spagnol, Paul L. Sorgen, Hamid Band, Vimla Band, Gloria E. O. Borgstahl

Publikováno v: AIMS Biophysics, Vol 3, Iss 1, Pp 195-210 (2016)

The human homolog of Drosophila ecdysoneless protein (ECD) is a p53 binding protein that stabilizes and enhances p53 functions. Homozygous deletion of mouse Ecd is early embryonic lethal and Ecd deletion delays G1-S cell cycle progression. Importantl

Externí odkaz: https://doaj.org/article/783855f100574a31999623b0380c8c6c

Characterization of the Structure and Intermolecular Interactions between the Connexin40 and Connexin43 Carboxyl-terminal and Cytoplasmic Loop Domains

Autor: Heidi Vitrac, Sarah Brownell, Paul L. Sorgen, Sylvie Chenavas, Admir Kellezi, Gaelle Spagnol, Vincent Forge, Denis Bouvier, Fabien Kieken

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (49), pp.34257-34271. ⟨10.1074/jbc.M109.039594⟩
Journal of Biological Chemistry, 2009, 284 (49), pp.34257-34271. ⟨10.1074/jbc.M109.039594⟩

International audience; Gap junctions are intercellular channels that allow the passage of ions, small molecules, and second messengers that are essential for the coordination of cellular function. They are formed by two hemichannels, each constitute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e8457a664c324f10e1516ae2828cec
https://doi.org/10.1074/jbc.m109.039594

Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction

Autor: Paul L. Sorgen, Nancy Mutsaers, Kelly Virgil, Bethany J. Hirst-Jensen, Admir Kellezi, Heather S. Duffy, Elena Dolmatova, Andrew L. Wit, Fabien Kieken

Publikováno v: Circulation research. 104(9)

Lateralization of the ventricular gap junction protein connexin 43 (Cx43) occurs in epicardial border zone myocytes following myocardial infarction (MI) and is arrhythmogenic. Alterations in Cx43 protein partners have been hypothesized to play a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65482258334b9881f5784fe957edb6b
https://pubmed.ncbi.nlm.nih.gov/19342602