Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Admassu Abebe"'
Autor:
Deniz Erdemir, John Gawel, Bereket Yohannes, Phillip Yates, Dan Tang, Khan Ha, Brian Breza, Elyse DiMaso, Admassu Abebe, Jessica Zombek
Publikováno v:
Journal of Pharmaceutical Sciences.
Continuous direct compression (CDC) of solid oral dosage forms requires materials exhibiting acceptable flow and compression properties. The desired active pharmaceutical ingredient (API) powder properties can be difficult to achieve through conventi
Autor:
Admassu Abebe, Bereket Yohannes
Publikováno v:
Powder Technology. 383:11-18
During early drug product development, methods for characterization of mechanical attributes are developed for flat, round tablets. However, there is a lack of understanding on how to compute the tensile strength of shaped tablets, which makes determ
Autor:
S. Kiang, Bereket Yohannes, Admassu Abebe, Faranak Nikfar, Marcial Gonzalez, Omar Sprockel, Alberto M. Cuitiño
Publikováno v:
International Journal of Pharmaceutics. 529:597-607
A mechanistic particle scale model is proposed for bilayer tablet compaction. Making bilayer tablets involves the application of first layer compaction pressure on the first layer powder and a second layer compaction pressure on entire powder bed. Th
Autor:
Lawrence De Belder, Hung-Ren Homer Lin, Ian Leavesley, Gurjit Bajwa, Ahmad Almaya, Dan Blackwood, Admassu Abebe, Jayanthy Jayanth, Anthony Tantuccio, Karthik Nagapudi, James DiNunzio, Robert F. Meyer
Publikováno v:
Journal of Pharmaceutical Sciences. 106:930-943
Continuous manufacturing (CM) has emerged in the pharmaceutical industry as a paradigm shift with significant advantages related to cost, efficiency, flexibility, and higher assurance of quality. The inherent differences from batch processes justify
Autor:
Mike Tobyn, Faranak Nikfar, Admassu Abebe, Ana Patricia Ferreira, Omar Sprockel, Dolapo Olusanmi
Publikováno v:
International Journal of Pharmaceutics. 514:335-340
In the oral solid dosage form space, material physical properties have a strong impact on the behaviour of the formulation during processing. The ability to identify materials with similar characteristics (and thus expected to exhibit similar behavio
Autor:
Faranak Nikfar, Omar Sprockel, S. Kang, Bereket Yohannes, Admassu Abebe, Marcial Gonzalez, Alberto M. Cuitiño
Publikováno v:
Powder Technology. 274:372-378
The role of fine particles on compaction of powders and the resultant compact was studied experimentally. Samples of powders were prepared by successively removing fine particles from microcrystalline cellulose and lactose monohydrate powders. This m
Autor:
Ilgaz Akseli, Faranak Nikfar, Alberto M. Cuitiño, Omar Sprockel, Kottala Niranjan Kumar, Admassu Abebe
Publikováno v:
Powder Technology. 239:300-307
The interfacial strength of nearly planar surfaces between two layers of powder compacted solids produced by sequentially consolidating each layer into a bilayer solid was characterized. In this study, fracture mechanics principles were applied to ev
Publikováno v:
Powder Technology. 236:30-36
The interest in bilayer tablet as an oral immediate-release/controlled-release system has substantially increased in the past decade. However, during the production of such tablets, lack of sufficient bonding and adhesion at interfaces between adjace
Autor:
James S. Bergum, Faranak Nikfar, Kottala Niranjan Kumar, Alberto M. Cuitiño, Admassu Abebe, Omar Sprockel
Publikováno v:
AAPS PharmSciTech. 13:1190-1196
Ambient air humidity and temperature are known to influence the mechanical strength of tablets. The objective of this work is to understand the influence of processing parameters and environmental conditions (humidity and temperature) on the strength
Autor:
Howard J. Stamato, Admassu Abebe, Kyle Martin, Kottala Niranjan Kumar, Antara Majumdar, Rekha Keluskar, Jason Franck
Publikováno v:
Pharmaceutical development and technology. 20(2)
There has been increasing interest in fixed dose combination (FDC) therapy. Multi-layer tablets are a popular choice among various technologies to deliver FDCs. In most cases, round flat faced tooling is used in testing tablets as they have the simpl