Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD.

Autor: Kirkeby A; Wallenberg Neuroscience Center, Wallenberg Center for Molecular Medicine and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) and Department of Neuroscience, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: agnete.kirkeby@med.lu.se., Nelander J; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Hoban DB; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Rogelius N; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Bjartmarz H; Department of Neurosurgery, Skåne University Hospital, 221 85 Lund, Sweden., Storm P; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Fiorenzano A; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Adler AF; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Vale S; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Mudannayake J; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Zhang Y; Wallenberg Neuroscience Center, Wallenberg Center for Molecular Medicine and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Cardoso T; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Mattsson B; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Landau AM; Department of Nuclear Medicine & PET-Center and Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark., Glud AN; Center for Experimental Neuroscience (CENSE), Department of Neurosurgery, Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark., Sørensen JC; Center for Experimental Neuroscience (CENSE), Department of Neurosurgery, Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark., Lillethorup TP; Department of Nuclear Medicine & PET-Center and Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark., Lowdell M; Centre for Cell, Gene and Tissue Therapeutics, Royal Free NHS Foundation Trust, Royal Free Hospital, London NW3 2QG, UK., Carvalho C; Centre for Cell, Gene and Tissue Therapeutics, Royal Free NHS Foundation Trust, Royal Free Hospital, London NW3 2QG, UK., Bain O; Centre for Cell, Gene and Tissue Therapeutics, Royal Free NHS Foundation Trust, Royal Free Hospital, London NW3 2QG, UK., van Vliet T; Department of Neurology, Skåne University Hospital, 221 85 Lund, Sweden., Lindvall O; Lund Stem Cell Center and Department of Clinical Sciences Lund, Lund University, 221 84 Lund, Sweden., Björklund A; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Harry B; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK., Cutting E; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK., Widner H; Department of Neurology, Skåne University Hospital, 221 85 Lund, Sweden., Paul G; Department of Neurology, Skåne University Hospital, 221 85 Lund, Sweden; Wallenberg Neuroscience Center, Wallenberg Center for Molecular Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden., Barker RA; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK., Parmar M; Wallenberg Neuroscience Center, MultiPark and Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden. Electronic address: malin.parmar@med.lu.se.

Publikováno v: Cell stem cell [Cell Stem Cell] 2023 Oct 05; Vol. 30 (10), pp. 1299-1314.e9.

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery.

Autor: Alekseenko Z; Department of Cell and Molecular Biology, Karolinska Institutet, 171 65, Stockholm, Sweden., Dias JM; Department of Cell and Molecular Biology, Karolinska Institutet, 171 65, Stockholm, Sweden., Adler AF; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 221 84, Lund, Sweden.; Lund Stem Cell Center, Lund University, 22184, Lund, Sweden., Kozhevnikova M; Department of Cell and Molecular Biology, Karolinska Institutet, 171 65, Stockholm, Sweden., van Lunteren JA; Department of Biosciences and Nutrition, Karolinska Institutet, 141 83, Huddinge, Sweden., Nolbrant S; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 221 84, Lund, Sweden.; Lund Stem Cell Center, Lund University, 22184, Lund, Sweden., Jeggari A; Department of Cell and Molecular Biology, Karolinska Institutet, 171 65, Stockholm, Sweden., Vasylovska S; Department of Cell and Molecular Biology, Karolinska Institutet, 171 65, Stockholm, Sweden., Yoshitake T; Department of Physiology and Pharmacology, Karolinska Institutet, 171 65, Stockholm, Sweden., Kehr J; Department of Physiology and Pharmacology, Karolinska Institutet, 171 65, Stockholm, Sweden.; Pronexus Analytical AB, Bromma, Sweden., Carlén M; Department of Biosciences and Nutrition, Karolinska Institutet, 141 83, Huddinge, Sweden.; Department of Neuroscience, Karolinska Institutet, 171 65, Stockholm, Sweden., Alexeyenko A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 65, Stockholm, Sweden.; Science for Life Laboratory, 171 21, Solna, Sweden., Parmar M; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 221 84, Lund, Sweden.; Lund Stem Cell Center, Lund University, 22184, Lund, Sweden., Ericson J; Department of Cell and Molecular Biology, Karolinska Institutet, 171 65, Stockholm, Sweden. johan.ericson@ki.se.

Publikováno v: Nature communications [Nat Commun] 2022 Jun 01; Vol. 13 (1), pp. 3046. Date of Electronic Publication: 2022 Jun 01.

Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells.

Autor: Tan, Jerome^1,2,3 (AUTHOR), Chen, Jiahui¹ (AUTHOR), Roxby, Daniel^1,3 (AUTHOR), Chooi, Wai Hon⁴ (AUTHOR), Nguyen, Tan Dai³ (AUTHOR), Ng, Shi Yan⁴ (AUTHOR), Han, Jongyoon^3,5,6 (AUTHOR) jyhan@mit.edu, Chew, Sing Yian^1,3,7,8 (AUTHOR) sychew@ntu.edu.sg

Publikováno v: Stem Cell Research & Therapy. 12/5/2024, Vol. 15 Issue 1, p1-15. 15p.

Promotion of nerve regeneration and motor function recovery in SCI rats using LOCAS-iPSCs-NSCs.

Autor: Xu, Gang^1,2 (AUTHOR) xugang@dmu.edu.cn, Ge, Rui^1,2 (AUTHOR), Zhang, Chunli^3,4 (AUTHOR), Zhao, Ziteng^3,4 (AUTHOR), Han, Liwei^3,4 (AUTHOR), Zhang, Wanhao¹ (AUTHOR), Yue, WenJie¹ (AUTHOR), Zhang, Jing¹ (AUTHOR), Zhao, Yantao^3,4 (AUTHOR), Hou, Shuxun^3,4 (AUTHOR), Li, Li^3,4 (AUTHOR) lili304@126.com, Wang, Peng⁵ (AUTHOR) wangpeng301@foxmail.com

Publikováno v: Stem Cell Research & Therapy. 10/23/2024, Vol. 15 Issue 1, p1-12. 12p.

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.

Autor: Tiklová K; Ludwig Institute for Cancer Research, Box 240, SE-171 77, Stockholm, Sweden.; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden., Nolbrant S; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Fiorenzano A; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Björklund ÅK; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Husargatan 3, SE-752 37, Uppsala, Sweden., Sharma Y; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Heuer A; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Gillberg L; Ludwig Institute for Cancer Research, Box 240, SE-171 77, Stockholm, Sweden.; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden., Hoban DB; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Cardoso T; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Adler AF; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Birtele M; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden., Lundén-Miguel H; Ludwig Institute for Cancer Research, Box 240, SE-171 77, Stockholm, Sweden., Volakakis N; Ludwig Institute for Cancer Research, Box 240, SE-171 77, Stockholm, Sweden., Kirkeby A; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden.; Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200, Copenhagen, Denmark., Perlmann T; Ludwig Institute for Cancer Research, Box 240, SE-171 77, Stockholm, Sweden. thomas.perlmann@ki.se.; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden. thomas.perlmann@ki.se., Parmar M; Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, 22184, Lund, Sweden. malin.parmar@med.lu.se.

Publikováno v: Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2434. Date of Electronic Publication: 2020 May 15.