Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model

Autor: Adler, Drew, Linden, Jennifer R., Shetty, Samantha V., Ma, Yinghua, Bokori-Brown, Monika, Titball, Richard W., Vartanian, Timothy

Publikováno v: In iScience 31 May 2019 15:39-54

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Autor: Wallach, Thomas, Mossmann, Zoé J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Krüger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Schüler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)

Background MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc34876b69d6c459493217b655924b4

Additional file 11 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Autor: Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija

Additional file 11. Intrathecal pre-treatment with LPS enhances miR-298-5p- and miR-100-5p-induced neurodegeneration and microglial accumulation. 1 ��g LPS was injected intrathecally into C57BL/6 mice. After 16 h, mice were injected intrathecally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153c067774c36730f609ca6da6d328da

Additional file 9 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Autor: Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija

Additional file 9. miR-298-5p and miR-100-5p enter neurons and co-localize to their endosomal compartment and TLR7. (a) Enriched C57BL/6 cortical neurons were incubated with 40 ��g/ml pHrodo Red Dextran serving as endosomal marker for 20 min. Sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94896969b49952bbafa2751a8a4c13e3

Additional file 7 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Autor: Wallach, Thomas, Mossmann, Zo�� J., Szczepek, Michal, Wetzel, Max, Machado, Rui, Raden, Martin, Miladi, Milad, Kleinau, Gunnar, Kr��ger, Christina, Dembny, Paul, Adler, Drew, Zhai, Yuanyuan, Kumbol, Victor, Dzaye, Omar, Sch��ler, Jutta, Futschik, Matthias, Backofen, Rolf, Scheerer, Patrick, Lehnardt, Seija

Additional file 7. Microscale thermophoresis measurement of let-7g-5p and specificity control. Binding affinity measurements of the purified polyhistidine-tagged human TLR8 protein and (a) let-7g-5p and (b) miR-298-5p using microscale thermophoresis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e224890c809d3f85d2690d8e4f2997b