Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aditya S. Paul"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundChemotherapies for malaria and babesiosis frequently succumb to the emergence of pathogen-related drug-resistance. Host-targeted therapies are thought to be less susceptible to resistance but are seldom considered for treatment of these dis
Externí odkaz:
https://doaj.org/article/874d85924e1b42a9aa1677a88f256ce2
Autor:
Aditya S. Paul, Alexandra Miliu, Joao A. Paulo, Jonathan M. Goldberg, Arianna M. Bonilla, Laurence Berry, Marie Seveno, Catherine Braun-Breton, Aziz L. Kosber, Brendan Elsworth, Jose S. N. Arriola, Maryse Lebrun, Steven P. Gygi, Mauld H. Lamarque, Manoj T. Duraisingh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Plasmodium protein phosphatase PP1 is essential for the asexual proliferation of malaria parasites. Here the authors show that PP1 regulates egress of parasites from host red blood cells, integrating parasite intrinsic pathways with environmental sig
Externí odkaz:
https://doaj.org/article/7d2715bdc7484f8c88c035dcb70a2f3f
Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes
Autor:
Marc-Jan Gubbels, Caroline D. Keroack, Sriveny Dangoudoubiyam, Hanna L. Worliczek, Aditya S. Paul, Ciara Bauwens, Brendan Elsworth, Klemens Engelberg, Daniel K. Howe, Isabelle Coppens, Manoj T. Duraisingh
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Cellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around humans. The horizon on cell division variants is expanded here by advancing insights on the fasc
Externí odkaz:
https://doaj.org/article/9052160c60a04e87962310f46bd833ae
Autor:
Sudhir Kumar, Manish Kumar, Roseleen Ekka, Jeffrey D. Dvorin, Aditya S. Paul, Anil K. Madugundu, Tim Gilberger, Harsha Gowda, Manoj T. Duraisingh, T. S. Keshava Prasad, Pushkar Sharma
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1
Externí odkaz:
https://doaj.org/article/74c94d5ff9f648c2a5538d04ec0915e0
Autor:
Brendan Elsworth, Caroline D. Keroack, Yasaman Rezvani, Jacob A. Tennessen, Samantha A. Sack, Aditya S. Paul, Cristina K. Moreira, Marc-Jan Gubbels, Kourosh Zarringhalam, Manoj T. Duraisingh
SummaryA unique aspect of apicomplexan biology is the requirement for egress from and invasion into host red blood cells (RBCs). The cellular mechanisms and molecular mediators of RBC egress and invasion remain poorly characterized inBabesiaspp., a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cec07b27d3e2f6e8bf8ae7ba771627e3
https://doi.org/10.1101/2022.02.17.480550
https://doi.org/10.1101/2022.02.17.480550
Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes
Autor:
Caroline D. Keroack, Klemens Engelberg, Daniel K. Howe, Aditya S. Paul, Ciara Bauwens, Isabelle Coppens, Sriveny Dangoudoubiyam, Hanna L. Worliczek, Brendan Elsworth, Manoj T. Duraisingh, Marc-Jan Gubbels
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Cellular reproduction defines life, yet our textbook-level understanding of cell division is limited to a small number of model organisms centered around humans. The horizon on cell division variants is expanded here by advancing insights on the fasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ecd58a4270e8219067b882f7da8b00
https://doi.org/10.3389/fcimb.2020.00269
https://doi.org/10.3389/fcimb.2020.00269
Autor:
Laurence Berry, Alexandra Miliu, Joao A. Paulo, Steven P. Gygi, Catherine Braun-Breton, Marie Seveno, Jonathan M. Goldberg, Maryse Lebrun, Brendan Elsworth, Manoj T. Duraisingh, Jose S. N. Arriola, Aziz L. Kosber, Arianna M. Bonilla, Aditya S. Paul, Mauld H. Lamarque
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. We carried out a functional analysis of the Plasmod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c790f7ab0759696e4be1e3e94e979a4e
https://doi.org/10.1101/2020.01.05.890483
https://doi.org/10.1101/2020.01.05.890483
Autor:
Jeffrey D. Dvorin, Tim W. Gilberger, Aditya S. Paul, Sudhir Kumar, Pushkar Sharma, Roseleen Ekka, Manish Kumar, Harsha Gowda, Manoj T. Duraisingh, Anil K. Madugundu, T. S. Keshava Prasad
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but its precise function and substrates remain largely unknown. Using a conditional kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17152d7d952ba41619d99aa153782a73
https://doaj.org/article/74c94d5ff9f648c2a5538d04ec0915e0
https://doaj.org/article/74c94d5ff9f648c2a5538d04ec0915e0
Autor:
Manoj T. Duraisingh, Aditya S. Paul
Publikováno v:
Trends in Parasitology. 34:95-97
Proliferation of malaria parasites in a host requires mechanisms to spread between red blood cells (RBCs). We discuss here the implications for biology and antimalarial drug development of companion studies that establish the requirement of two Plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec248063a36c598fa0b35daad43f9651
https://doi.org/10.1016/j.pt.2017.11.012
https://doi.org/10.1016/j.pt.2017.11.012
A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion
Autor:
Charles Frantzreb, Natasha S. Barteneva, Yoshihiko Tani, Steven P. Gygi, Manoj T. Duraisingh, Aditya S. Paul, Seishi Watanabe, John G. Doench, Michael P. Weekes, Mischka A. Moechtar, Roger C. Wiegand, Joao A. Paulo, Junko Takahashi, Carlo Brugnara, David E. Root, Rays H. Y. Jiang, Jonathan M. Goldberg, Luis Nobre, Elizabeth S. Egan
Publikováno v:
Science. 348:711-714
A way to dissect malaria's secrets Malaria has exerted a strong selective force on the human genome. However, efforts to identify host susceptibility factors have been hindered by the absence of a nucleus in red blood cells. Egan et al. developed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60534f86c4bc45a768ad2b2dc5f1abd0
https://doi.org/10.1126/science.aaa3526
https://doi.org/10.1126/science.aaa3526