Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Aditya R. Thawani"'
Autor:
Joaquin Calbo, Aditya R. Thawani, Rosina S. L. Gibson, Andrew J. P. White, Matthew J. Fuchter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2753-2764 (2019)
Azoarenes remain privileged photoswitches – molecules that can be interconverted between two states using light – enabling a huge range of light addressable multifunctional systems and materials. Two key innovations to improve the addressability
Externí odkaz:
https://doaj.org/article/c3916531e6a141f69410c85cdbc1d1cf
Autor:
Jake L. Greenfield, Aditya R. Thawani, Magdalena Odaybat, Rosina S.L. Gibson, Thomas B. Jackson, Matthew J. Fuchter
Publikováno v:
Molecular Photoswitches. :83-112
Autor:
Don T. Fisher, Gillian F. Watt, Ian Churcher, Laurie J. Gordon, Andrea D Gonçalves, Alina Mares, Phoebe Dace, Rakesh Nagilla, Bartholomew J. Votta, Ian Edward David Smith, John D. Harling, Pamela A. Haile, Afjal Hussain Miah, Paul Giffen, Paul Scott-Stevens, Aditya R. Thawani, Mark David Rackham, Jane Denyer
Publikováno v:
Journal of Medicinal Chemistry. 64:12978-13003
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) is an important kinase of the innate immune system. Herein, we describe the optimization of a series of RIPK2 PROTACs which recruit members of the inhibitor of apoptosis (IAP) family of E
Autor:
Ryan-Rhys Griffiths, Jake L. Greenfield, Aditya R. Thawani, Arian R. Jamasb, Henry B. Moss, Anthony Bourached, Penelope Jones, William McCorkindale, Alexander A. Aldrick, Matthew J. Fuchter, Alpha A. Lee
Publikováno v:
Chemical science. 13(45)
Photoswitchable molecules display two or more isomeric forms that may be accessed using light. Separating the electronic absorption bands of these isomers is key to selectively addressing a specific isomer and achieving high photostationary states wh
Autor:
Jenni Cryan, Don T. Fisher, Michael Reilly, Ian Edward David Smith, Anna Vossenkämper, Gillian F. Watt, Ian Churcher, John D. Harling, Allison M. Beal, Thomas T. MacDonald, Alina Mares, Phoebe Dace, Bartholomew J. Votta, Marcus Bantscheff, Jane Denyer, Paul Scott-Stevens, Afjal Hussain Miah, Andrew B. Benowitz, Aditya R. Thawani, Carol A. Capriotti, Mark David Rackham, Nico Zinn, Pamela A. Haile
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of intracellular proteins through the recruitment of E3 ligase complexes to non-native protein su
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2753-2764 (2019)
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2753-2764 (2019)
Azoarenes remain privileged photoswitches – molecules that can be interconverted between two states using light – enabling a huge range of light addressable multifunctional systems and materials. Two key innovations to improve the addressability
Autor:
Katie Mason, Sarah Elkhalifa, Nattawadee Panyain, Edward W. Tate, Aditya R. Thawani, Aurélien Godinat, Sofía Lachiondo-Ortega, Lisa M. Smith, Jeanine A. Harrigan
Publikováno v:
RSC Medicinal Chemistry
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme (DUB), is a potential drug target in various cancers, and liver and lung fibrosis. However, bona fide functions and substrates of UCHL1 remain poorly understood. Herein, we re
Autor:
Dipayan Chaudhuri, Pui-ying Lam, Andrew J. P. White, Matthew J. Fuchter, Randall T. Peterson, Enrique Balderas, Aditya R. Thawani
Publikováno v:
J Am Chem Soc
Chemo-optogenetics has produced powerful tools for optical control of cell activity, but current tools suffer from a variety of limitations including low unitary conductance, the need to modify the target channel, or the inability to control both on
Autor:
Alpha A. Lee, Arian R. Jamasb, Penelope J. Jones, Anthony Bourached, William McCorkindale, Alexander A. Aldrick, Ryan-Rhys Griffiths, Aditya R. Thawani
The space of synthesizable molecules is greater than $10^{60}$, meaning only a vanishingly small fraction of these molecules have ever been realized in the lab. In order to prioritize which regions of this space to explore next, synthetic chemists ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbf81a71ef7415800914210fde99299
https://doi.org/10.26434/chemrxiv.12609899
https://doi.org/10.26434/chemrxiv.12609899