Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Aditi Shastri"'
Autor:
Charan Thej Reddy Vegivinti, Praneeth Reddy Keesari, Sindhusha Veeraballi, Catarina Maria Pina Martins Maia, Ansh Krishnachandra Mehta, Rohit Reddy Lavu, Rahul Kumar Thakur, Sri Harsha Tella, Riya Patel, Venkata Kiranmayi Kakumani, Yashwitha Sai Pulakurthi, Srinivas Aluri, Ritesh Kumar Aggarwal, Nandini Ramachandra, Rongbao Zhao, Srabani Sahu, Aditi Shastri, Amit Verma
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-12 (2023)
Abstract Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow microenvironment and associated with aging, clonal hematopoiesis, myelodysplastic syndromes (MDS), an
Externí odkaz:
https://doaj.org/article/683079f0ef6041bf9cc850cc07833d73
Autor:
John X. Wei, Aditi Shastri, R. Alejandro Sica, Ioannis Mantzaris, Noah Kornblum, Urvi Shah, Murali Janakiram, Kira Gritsman, Amit Verma, Mendel Goldfinger, Dennis Cooper, Nishi Shah
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
Over the past two decades, there have been significant advances in the treatment of multiple myeloma which has led to an improvement in overall survival.1,2 However, a notable proportion of patients continue to experience early mortality (EM), define
Externí odkaz:
https://doaj.org/article/4a2aa3345bc940d8942786c0ca7ada9c
Autor:
Kateryna Fedorov, Eric Feldman, Yogen Saunthararajah, Aditi Shastri, Noah Kornblum, Alejandro Sica, Nishi Shah, Marina Konopleva, Kira Gritsman, Ira Braunschweig, David Levitz, Dennis Cooper, Monica Comas, Kith Pradhan, Amit Verma, Ioannis Mantzaris, Mendel Goldfinger
Publikováno v:
HemaSphere, Vol 7, p e90768e2 (2023)
Externí odkaz:
https://doaj.org/article/9099faaac4d44be1913468864d86c9e4
Autor:
Ioannis Mantzaris, Mendel Goldfinger, David Levitz, Kateryna Fedorov, Annemarie Munoz, Nicole Chambers, Karen Fehn, Aradhika Dhawan, Joel Victor, Nishi Shah, Aditi Shastri, Noah Kornblum, Alejandro Sica, Kira Gritsman, Dennis Cooper, Mimi Kim, Amit K. Verma, Ulrich Steidl, Eric Feldman, Marina Konopleva
Publikováno v:
HemaSphere, Vol 7, p e46119b8 (2023)
Externí odkaz:
https://doaj.org/article/9f89dfd25cfc448187db46e647f1e651
Autor:
Srinivas Aluri, Aarif Ahsan, Sheida Hayati, Manuel Ugidos, Punit Shah, Kate Lizotte, Samarpana Chakraborty, Kith Pradhan, Srabani Sahu, Shahina Maqbool, Aditi Shastri, Ashok Dongre, Uwe Platzbecker, Anita Gandhi, Rajasekhar Nvs Suragani, Sadanand Vodala, Amit Verma
Publikováno v:
HemaSphere, Vol 7, p e8463948 (2023)
Externí odkaz:
https://doaj.org/article/f21798ad8f984bc889d577e75e7009de
Autor:
Yang Zhang, Xiaoyi Chen, Huamin Wang, Shanisha Gordon-Mitchell, Srabani Sahu, Tushar D. Bhagat, Gaurav Choudhary, Srinivas Aluri, Kith Pradhan, Plabani Sahu, Milagros Carbajal, Hui Zhang, Beamon Agarwal, Aditi Shastri, Robert Martell, Daniel Starczynowski, Ulrich Steidl, Anirban Maitra, Amit Verma
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Advanced pancreatic ductal adenocarcinoma (PDAC) is usually an incurable malignancy that needs newer therapeutic targets. Interleukin-1 receptor accessory protein (IL1RAP) is an innate immune mediator that regulates activation of pro-inflamm
Externí odkaz:
https://doaj.org/article/5169c822e746461397a048bb851da686
Autor:
Emma Rabinovich, Kith Pradhan, R. Alejandro Sica, Lizamarie Bachier-Rodriguez, Ioannis Mantzaris, Noah Kornblum, Aditi Shastri, Kira Gritsman, Mendel Goldfinger, Amit Verma, Ira Braunschweig
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-4 (2021)
Abstract Anti-CD19 chimeric antigen receptor T-cell therapies have shown striking clinical activity in diffuse large B-cell lymphoma but robust biomarkers predictive of responsiveness are still needed. We treated a multi-ethnic cohort of 31 diffuse l
Externí odkaz:
https://doaj.org/article/d6a2fbb6a1074b98af04337008c866f1
Autor:
Samarpana Chakraborty, Lauren C. Shapiro, Sofia de Oliveira, Bianca Rivera-Pena, Amit Verma, Aditi Shastri
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-10 (2021)
Abstract Even though genetic perturbations and mutations are important for the development of myeloid malignancies, the effects of an inflammatory microenvironment are a critical modulator of carcinogenesis. Activation of the innate immune system thr
Externí odkaz:
https://doaj.org/article/98dd9741bceb4070813861a319163c94
Autor:
Nora E. Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D. Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 9, Pp 1-8 (2021)
Abstract The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore the mechanisms underlying the selective sensitivity of mutant leukemia cells to VEN and
Externí odkaz:
https://doaj.org/article/ebcdc68081b74bb08aadabec941cc80f
Autor:
Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Ritesh Aggarwal, Sarah Aminov, Leya Schwartz, Violetta Steeples, Robert N Booher, Murali Ramachandra, Maria Samson, Milagros Carbajal, Kith Pradhan, Teresa V Bowman, Manoj M Pillai, Britta Will, Amittha Wickrema, Aditi Shastri, Robert K Bradley, Robert E Martell, Ulrich G Steidl, Evripidis Gavathiotis, Jacqueline Boultwood, Daniel T Starczynowski, Amit Verma
Publikováno v:
eLife, Vol 11 (2022)
Background: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immun
Externí odkaz:
https://doaj.org/article/530c5c84de264ae68b3135c39fce561b