Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Aditi Phadke"'
Autor:
Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal, Kanneboyina Nagaraju
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Background Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, sarcomere formation,
Externí odkaz:
https://doaj.org/article/050731eeba884453b57d2710d7a8e532
Autor:
Arpana Sali, Gina M Many, Heather Gordish-Dressman, Jack H van der Meulen, Aditi Phadke, Christopher F Spurney, Avital Cnaan, Eric P Hoffman, Kanneboyina Nagaraju
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66617 (2013)
In Duchenne muscular dystrophy (DMD), loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential,
Externí odkaz:
https://doaj.org/article/6365d2c0d17747f2b375666423eb7e53
Autor:
Jack H. Van der Meulen, Jennifer M. Peterson, Helen Johnston, Aditi Phadke, Jessica F. Boehler, Aurelia Defour, Vanessa E. Jahnke, Kanneboyina Nagaraju, Qing Yu, Jyoti K. Jaiswal, Kitipong Uaesoontrachoon
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-17 (2020)
Skeletal Muscle
Skeletal Muscle
BackgroundNonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, sarcomere formation, and muscle
Autor:
Jesse M. Damsker, Susan M Knoblach, Melissa Morales, Terence A. Partridge, Kanneboyina Nagaraju, Qing Yu, Michaelyn R. Cornish, Aditi Phadke, Rachel Lipson, Karuna Panchapakesan, Ila Kanneboyina, Priya Kanneboyina, Alyson A. Fiorillo
Publikováno v:
Inflamm Res
OBJECTIVE AND DESIGN: The objective of this study was to assess the effect of vamorolone, a first-in-class dissociative steroidal compound, to inhibit inflammation when administered after disease onset in the murine collagen antibody-induced arthriti
Autor:
Aditi Phadke, Lisa G. Rider, Eric P. Hoffman, Sree Rayavarapu, Kanneboyina Nagaraju, Frederick W. Miller, Svetlana Ghimbovschi
Publikováno v:
Rheumatology. 55:1673-1680
Objective To identify muscle gene expression patterns that predict rituximab responses and assess the effects of rituximab on muscle gene expression in PM and DM. Methods In an attempt to understand the molecular mechanism of response and non-respons
Autor:
Aditi Phadke, Kanneboyina Nagaraju, Daryl Despres, Brent McCright, Prajakta Varadkar, Matthew Kraman, Julie Lozier
Publikováno v:
Developmental Dynamics. 243:778-790
Background: Protein Phosphatase 2A (PP2A) function is controlled by regulatory subunits that modulate the activity of the catalytic subunit and direct the PP2A complex to specific intracellular locations. To study PP2A's role in signal transduction p
Autor:
Christopher R. Heier, Edward M. Connor, Kathleen Tatem, Kanneboyina Nagaraju, Sarah Jordan, Luana Scheffer, Qing Yu, Tony Huynh, Michael E. Calhoun, Jack H. Van der Meulen, Olga Rodriguez, John M. McCall, Heather Gordish-Dressman, Erica K.M. Reeves, Sherry Dadgar, Eric P. Hoffman, Chris Albanese, Jesse M. Damsker, Arpana Sali, Brittany K. Miller, James L Quinn, Aditi Phadke, Blythe C. Dillingham, Jyoti K. Jaiswal
Publikováno v:
EMBO Molecular Medicine
Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches of the plasma membrane and chronic inflammation in Duchenne muscular dystrophy (DMD). Current management by glucocorticoids has unclear molecular benefits a
Autor:
Colin L. Stewart, Roland Foisner, Juliet A. Ellis, Aditi Phadke, Terence A. Partridge, Peter S. Zammit, Viola F. Gnocchi, Henry Liu, Tatiana V. Cohen, Jonathan Cohen
Publikováno v:
Human Molecular Genetics. 22:2852-2869
Mutations in lamin A/C result in a range of tissue-specific disorders collectively called laminopathies. Of these, Emery-Dreifuss and Limb-Girdle muscular dystrophy 1B mainly affect striated muscle. A useful model for understanding both laminopathies
Autor:
Tatiana V. Cohen, Helen Johnston, Aditi Phadke, Terence A. Partridge, Heather Gordish-Dressman, Kanneboyina Nagaraju, Viola F. Gnocchi, William Duddy, Stephanie Duguez, SiewHui Low
Publikováno v:
Skeletal Muscle
Background Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits our ability to evaluate th
Autor:
Kathryn Thompson, Nils Landegren, A. Jimmy Ytterberg, Matteo Bottai, Jessica Herrath, Ingrid E. Lundberg, Cecilia Wick, Kanneboyina Nagaraju, Åsa Hallgren, Felipe Andrade, Jiri Vencovsky, Aditi Phadke, Roman A. Zubarev, Leonid Padyukov, Olof Danielsson, Lina-Marcela Diaz-Gallo, Inka Albrecht, Inger Nennesmo, Olga Krystufkova, Anna Tjärnlund, Marie Wahren-Herlenius, Olle Kämpe, Karine Chemin, Karin Johansson, William Coley, Anders Wikberg
Publikováno v:
The Journal of clinical investigation. 125(12)
Mutations of the gene encoding four-and-a-half LIM domain 1 (FHL1) are the causative factor of several X-linked hereditary myopathies that are collectively termed FHL1-related myopathies. These disorders are characterized by severe muscle dysfunction