Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adithya Srid"'
Autor:
Pamela E. Capendale, Inés García-Rodríguez, Anoop T. Ambikan, Lance A. Mulder, Josse A. Depla, Eline Freeze, Gerrit Koen, Carlemi Calitz, Vikas Sood, Renata Vieira de Sá, Ujjwal Neogi, Dasja Pajkrt, Adithya Sridhar, Katja C. Wolthers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Picornaviruses are a leading cause of central nervous system (CNS) infections. While genotypes such as parechovirus A3 (PeV-A3) and echovirus 11 (E11) can elicit severe neurological disease, the highly prevalent PeV-A1 is not associated with
Externí odkaz:
https://doaj.org/article/bda8e7616a1141d5a3a550360afea61c
Autor:
Nening M. Nanlohy, Nina Johannesson, Lucas Wijnands, Laura Arroyo, Jelle de Wit, Gerco den Hartog, Katja C. Wolthers, Adithya Sridhar, Susana Fuentes
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109771- (2024)
Summary: Host and microbiome intricately interact in the ecosystem of the human digestive tract, playing a crucial role in our health. These interactions can initiate immune responses in the epithelial cells, which, in turn, activate downstream respo
Externí odkaz:
https://doaj.org/article/553d6c2d90d447a79d3388e3c42bb6d9
Autor:
Lance A. Mulder, Josse A. Depla, Adithya Sridhar, Katja Wolthers, Dasja Pajkrt, Renata Vieira de Sá
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Background The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent protocol adaptations and m
Externí odkaz:
https://doaj.org/article/7240263d2b1b4f7ba69ff35d032ae700
Autor:
Georgios Stroulios, Tyler Brown, Giulia Moreni, Douglas Kondro, Alessandro Dei, Allen Eaves, Sharon Louis, Juan Hou, Wing Chang, Dasja Pajkrt, Katja C. Wolthers, Adithya Sridhar, Salvatore Simmini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Airway organoids are polarized 3D epithelial structures that recapitulate the organization and many of the key functions of the in vivo tissue. They present an attractive model that can overcome some of the limitations of traditional 2D and
Externí odkaz:
https://doaj.org/article/0d5f0d05c1cd42b89ea970cb80e10112
Autor:
Ikrame Aknouch, Inés García-Rodríguez, Francesca Paola Giugliano, Carlemi Calitz, Gerrit Koen, Hetty van Eijk, Nina Johannessson, Sjoerd Rebers, Lieke Brouwer, Vanesa Muncan, Koert J. Stittelaar, Dasja Pajkrt, Katja C. Wolthers, Adithya Sridhar
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Enterovirus A71 (EV-A71) can elicit a wide variety of human diseases such as hand, foot, and mouth disease and severe or fatal neurological complications. It is not clearly understood what determines the virulence and fitness of EV-A71. It has been o
Externí odkaz:
https://doaj.org/article/0c91f880a92f4ad5b2a6ecbaed1e1cc4
Autor:
Giulia Moreni, Hetty van Eijk, Gerrit Koen, Nina Johannesson, Carlemi Calitz, Kimberley Benschop, Jeroen Cremer, Dasja Pajkrt, Adithya Sridhar, Katja Wolthers
Publikováno v:
Viruses, Vol 15, Iss 9, p 1823 (2023)
Non-polio enteroviruses (EV) belonging to species C, which are highly prevalent in Africa, mainly among children, are poorly characterized, and their pathogenesis is mostly unknown as they are difficult to culture. In this study, human airway and int
Externí odkaz:
https://doaj.org/article/d2acbd6b261a481dbce99bbf05bb9161
Autor:
Leanne C. Helgers, Michel S. Bhoekhan, Dasja Pajkrt, Katja C. Wolthers, Teunis B. H. Geijtenbeek, Adithya Sridhar
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Enterovirus A71 (EV-A71) is a causative agent of life-threatening neurological diseases in young children. EV-A71 is highly infectious but it remains unclear how the virus disseminates from primary entry sites—the mucosa of the respiratory
Externí odkaz:
https://doaj.org/article/5c3474efdaa54defa714e24426b412a4
Autor:
Adithya Sridhar, Josse A. Depla, Lance A. Mulder, Eveliina Karelehto, Lieke Brouwer, Leonie Kruiswijk, Renata Vieira de Sá, Adam Meijer, Melvin M. Evers, Frank J. M. van Kuppeveld, Dasja Pajkrt, Katja C. Wolthers
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Enterovirus D68 (EV-D68) is an RNA virus that can cause outbreaks of acute flaccid paralysis (AFP), a polio-like disease. Before 2010, EV-D68 was a rare pathogen associated with mild respiratory symptoms, but the recent EV-D68 related increa
Externí odkaz:
https://doaj.org/article/21f27dcb3b52466392561c972a72bd2c
Autor:
Giulia Moreni, Ikrame Aknouch, Morris Ras, Lieke Brouwer, René Spijker, Carlemi Calitz, Koert J. Stittelaar, Adithya Sridhar, Katja C. Wolthers, Dasja Pajkrt
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Disease modelling plays a fundamental role in biomedical research, even more in virology where the virus depends strictly on its host for replication. Although animal models are extensively used in virology, there is an increasing demand for
Externí odkaz:
https://doaj.org/article/d4995a7846e44029b329068fa786f57a
Autor:
Josse A. Depla, Marina Sogorb-Gonzalez, Lance A. Mulder, Vivi M. Heine, Pavlina Konstantinova, Sander J. van Deventer, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Melvin M. Evers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 167-175 (2020)
The development of gene therapies for central nervous system disorders is challenging because it is difficult to translate preclinical data from current in vitro and in vivo models to the clinic. Therefore, we developed induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/6801bff942ae41f78c9545db8a90bbd9