Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

Autor: Adithya N Ananth, Ankur Mishra, Steffen Frey, Arvind Dwarkasing, Roderick Versloot, Erik van der Giessen, Dirk Görlich, Patrick Onck, Cees Dekker

Publikováno v: eLife, Vol 7 (2018)

Nuclear pore complexes (NPCs) lined with intrinsically disordered FG-domains act as selective gatekeepers for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The underlying physical mechanism of the intriguing selectivi

Externí odkaz: https://doaj.org/article/c55ffbe4d9e44d70a597dfa2e4264ff7

High-Speed Super-Resolution Imaging Using Protein-Assisted DNA-PAINT

Autor: Mike Filius, Adithya N. Ananth, Chirlmin Joo, Tao Ju Cui, John van der Oost, M.W. Docter, Jorrit W. Hegge

Publikováno v: Nano Letters
Nano letters, 4, 20, 2264-2270
Nano Letters 20 (2020) 4
Nano Letters, 20(4), 2264-2270
Nano Letters: a journal dedicated to nanoscience and nanotechnology, 20(4)

Super-resolution imaging allows for visualization of cellular structures on a nanoscale level. DNA-PAINT (DNA Point Accumulation In Nanoscale Topology) is a super-resolution method that depends on the binding and unbinding of DNA imager strands. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6519dd5152cd5d1aabb2e84a05256d2
http://europepmc.org/articles/PMC7146856

Author response: Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

Autor: Cees Dekker, Steffen Frey, Patrick Onck, Roderick Versloot, Erik Van der Giessen, Dirk Görlich, Arvind Dwarkasing, Ankur Mishra, Adithya N. Ananth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38c119678086da2fc07183e8986475eb
https://doi.org/10.7554/elife.31510.033

Superfast Motion of Catalytic Microjet Engines at Physiological Temperature

Autor: Oliver G. Schmidt, Samuel Sanchez, Marlitt Viehrig, Adithya N. Ananth, Vladimir M. Fomin

Publikováno v: Journal of the American Chemical Society. 133:14860-14863

There is a great interest in reducing the toxicity of the fuel used to self-propel artificial nanomachines. Therefore, a method to increase the efficiency of the conversion of chemicals into mechanical energy is desired. Here, we employed temperature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e323e6af4ecbec8e7971ee065b5d5d80
https://doi.org/10.1021/ja205012j

Biomimetic Nanopores for Studying Yeast Nuclear Pore Transport

Autor: Aravind Dwarkasing, Roderick Versloot, Dirk Goerlich, Adithya N. Ananth, Cees Dekker, Steffen Frey

Publikováno v: Biophysical Journal. 110:335a

Nuclear pore complexes (NPC) acts as the gatekeeper to and from the nucleus in eukaryotic cells. NPCs function by creating a selective diffusion barrier for molecules bigger than 30kD (∼5 nm), where all proteins are barred from transport, except im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3103d919f47d603eecc805a4f0ee968
https://doi.org/10.1016/j.bpj.2015.11.1803