Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt

Autor: Roberto Würth, Gianluigi Zona, Antonio Daga, Alessandra Pattarozzi, Daniela Fenoglio, Alessia Parodi, Monica Gatti, Alessandro Corsaro, Michela Massollo, Rodolfo Sirito, Federica Barbieri, Cecilia Marini, Tullio Florio, Adirana Bajetto, Gilberto Filaci, Gianmario Sambuceti

Publikováno v: Cell cycle (Georget. Tex.) 12 (2013): 145–156. doi:10.4161/cc.23050
info:cnr-pdr/source/autori:Wuerth, Roberto; Pattarozzi, Alessandra; Gatti, Monica; Bajetto, Adriana; Corsaro, Alessandro; Parodi, Alessia; Sirito, Rodolfo; Massollo, Michela; Marini, Cecilia; Zona, Gianluigi; Fenoglio, Daniela; Sambuceti, Gianmario; Filaci, Gilberto; Daga, Antonio; Barbieri, Federica; Florio, Tullio/titolo:Metformin selectively affects human glioblastoma tumor-initiating cell viability A role for metformin-induced inhibition of Akt/doi:10.4161%2Fcc.23050/rivista:Cell cycle (Georget. Tex.)/anno:2013/pagina_da:145/pagina_a:156/intervallo_pagine:145–156/volume:12

Cancer stem cell theory postulates that a small population of tumor-initiating cells is responsible for the development, progression and recurrence of several malignancies, including glioblastoma. In this perspective, tumor-initiating cells represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0012dcde637990dbf35561b45607fea
https://pubmed.ncbi.nlm.nih.gov/23255107