Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study

Autor: Nikos Papadimitriou, Caroline J Bull, Mazda Jenab, David J. Hughes, Joshua A Bell, Eleanor Sanderson, Nicholas J Timpson, George Davey Smith, Demetrius Albanes, Peter T Campbell, Sébastien Küry, Loic Le Marchand, Cornelia M Ulrich, Kala Visvanathan, Jane C Figueiredo, Polly A Newcomb, Rish K Pai, Ulrike Peters, Kostas K Tsilidis, Jolanda M.A. Boer, Emma E Vincent, Daniela Mariosa, Marc J Gunter, Tom G Richardson, Neil Murphy

Publikováno v: Papadimitriou, N, Bull, C J, Jenab, M, Hughes, D J, Bell, J A, Sanderson, E, Timpson, N J, Smith, G D, Albanes, D, Campbell, P T, Küry, S, Le Marchand, L, Ulrich, C M, Visvanathan, K, Figueiredo, J C, Newcomb, P A, Pai, R K, Peters, U, Tsilidis, K K, Boer, J M A, Vincent, E E, Mariosa, D, Gunter, M J, Richardson, T G & Murphy, N 2023, ' Separating the effects of early and later life adiposity on colorectal cancer risk : a Mendelian randomization study ', BMC Medicine, vol. 21, no. 1, 5, pp. 5 . https://doi.org/10.1186/s12916-022-02702-9

Background Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colorectal cancer risk. Methods We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98579b0d41d7081fe6ca8236531dce4a
https://pubmed.ncbi.nlm.nih.gov/36600297

Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

Autor: Torben Hansen, Anette P. Gjesing, Mette Hollensted, Hans Eiberg, Claus Thorn Ekstrøm, Oluf Pedersen

Publikováno v: BMC Medical Genetics
Hollensted, M, Ekstrøm, C T, Pedersen, O, Eiberg, H, Hansen, T & Gjesing, A P 2018, ' Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood : a family-based study ', BMC Medical Genetics, vol. 19, 207, pp. 1-9 . https://doi.org/10.1186/s12881-018-0718-2
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-9 (2018)
Hollensted, M, Ekstrøm, C T, Pedersen, O, Eiberg, H, Hansen, T & Gjesing, A P 2018, ' Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood : A family-based study ', BMC Medical Genetics, vol. 19, 207 . https://doi.org/10.1186/s12881-018-0718-2

Background The genetics of fetal insulin release and/or action have been suggested to affect fetal growth, adult insulin resistance and adult body composition. The genetic correlation between body composition at birth versus glycaemic regulation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dea10530c89f25d3e2c31d69ee2b28
http://europepmc.org/articles/PMC6278142

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations

Autor: Marguerite R. Irvin, B. E. Henderson, Aravinda Chakravarti, Unhee Lim, K. Dh Nguyen, Jeffrey Haessler, Jie Yao, Richard S. Cooper, Denise K. Houston, Jerome I. Rotter, Petra Buzkova, Ulrike Peters, Iona Cheng, Charles Kooperberg, Pamela J. Schreiner, Jian Gong, Myriam Fornage, Myron D. Gross, James S. Pankow, Kari E. North, Christopher A. Haiman, Rebecca D. Jackson, Sachiko Yoneyama, K. D. Taylor, Mark Leppert, Matthew A. Allison, Cora E. Lewis, Fredrick R. Schumacher, Christina L. Wassel, Tara C. Matise, Jonathan Boston, Loic Le Marchand, Eric Boerwinkle, Lindsay Fernández-Rhodes, Barbara Cochran, Misa Graff, Loreall Pooler, G. Ehret, Marylyn D. Ritchie, Steven Buyske, Nathan Pankratz, Rongling Li, Xiuqing Guo, Christopher S. Carlson, Stephanie A. Bien, Lynne R. Wilkens, Charles Gu, Y. Di Chen, Lew Kuller, Lucia A. Hindorff

Publikováno v: International journal of obesity (2005), vol 41, iss 2
International journal of obesity (2005)
International Journal of Obesity, Vol. 41, No 2 (2017) pp. 324-331

Background/objectivesCentral adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of body mass index (BMI) and are gaining clinically utility. Several studies rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d7e2c2b2885f9bbe961f41c0a1944b
https://escholarship.org/uc/item/7wq0q79w

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Autor: Pullen, Timothy J

Publikováno v: Pullen, T J 2016, ' Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function ', CELL METABOLISM, vol. 23, no. 5, pp. 821-836 . https://doi.org/10.1016/j.cmet.2016.04.003

Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::ed306f67788d55bbbd3b2f700c76dc47
https://kclpure.kcl.ac.uk/en/publications/c8ed4994-76eb-4ba9-92fd-0f09f7019677

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Autor: Philippe Froguel, Pekka Jousilahti, Harry Campbell, Ellen M. Schmidt, Vasiliki Lagou, John Andrew Pospisilik, Ivana Kolcic, Igor Rudan, Mark A. Sarzynski, Brigitte Kühnel, Robin Haring, Paul Knekt, Christian Gieger, Eero Kajantie, Jian Yang, Tuomas O. Kilpeläinen, Hans L. Hillege, Niek Verweij, Sarah H Wild, Torben Hansen, Leena Taittonen, Michael Boehnke, Mark I. McCarthy, Joel N. Hirschhorn, Åsa K. Hedman, D. Timothy Bishop, James F. Wilson, Jian'an Luan, Leo-Pekka Lyytikäinen, Nita G. Forouhi, Mark Walker, Elodie Eury, Konstantin Strauch, Aroon D. Hingorani, Nam H. Cho, Peter Vollenweider, Erkki Vartiainen, Jong-Young Lee, Fredrik Karpe, Jiali Han, Joanne M. Jordan, Chen Lu, Henri Wallaschofski, Anna A. E. Vinkhuyzen, Alan R. Shuldiner, David J. Hunter, Mario Falchi, Aron S. Buchman, Caroline S. Fox, Robert A. Scott, Chan Soo Shin, Fernando Rivadeneira, Zari Dastani, Veikko Salomaa, Weihua Zhang, Rui Li, John C. Chambers, Thorkild I. A. Sørensen, André G. Uitterlinden, David A. Bennett, Marianna Sanna, Claire Bellis, Lars Bertram, Karl Michaëlsson, Yingchang Lu, Marie Loh, Loic Yengo, Bok-Ghee Han, Priya Srikanth, Laura Pascoe, Peter Wagner, Philip L. De Jager, Oscar H. Franco, Yongmei Liu, Stavroula Kanoni, Simone Gärtner, Ruth J. F. Loos, Eric E. Schadt, Claes Ohlsson, Cornelia M. van Duijn, Jorma S. A. Viikari, Stephan J. L. Bakker, Tamara B. Harris, Pirro G. Hysi, Samuli Ripatti, John R. B. Perry, Stefan A. Czerwinski, Tune H. Pers, Angela Döring, Ghazaleh Fatemifar, Tarunveer S. Ahluwalia, Liesbeth Vandenput, Carrie M. Nielson, Claudia Langenberg, Carolina Medina-Gomez, Mike A. Nalls, Erik Ingelsson, Barbara McKnight, Niels Grarup, L. Adrienne Cupples, Torben Jørgensen, Satu Männistö, Jianbo Na, Cristen J. Willer, Tuomo Rankinen, Irene Mateo Leach, Cecilia M. Lindgren, Marie-Claude Vohl, Ryan W. Walker, Yun Ju Sung, Joanne M. Murabito, Natasja M. van Schoor, Mika Kivimäki, Nicholas J. Wareham, Lei Yu, Markku Laakso, Julia A. Newton Bishop, Pim van der Harst, Qibin Qi, Veronique Bataille, Clive Osmond, Alan F. Wright, Audrey C. Choh, Charles C. White, Felix R. Day, Ron T. Gansevoort, Tiina Laatikainen, Ozren Polasek, Johan G. Eriksson, Mark M. Iles, Dena G. Hernandez, Meena Kumari, Dmitry Shungin, Jeffrey R. O'Connell, Joseph M. Zmuda, Antti Jula, Hyung Jin Choi, Albert Hofman, Steven R. Cummings, Youfang Liu, Vilmundur Gudnason, J. Brent Richards, Michael Stumvoll, Ayse Demirkan, Teresa Ferreira, Rosalie A. M. Dhonukshe-Rutten, Rahel Eckardt, Lude Franke, Karen L. Mohlke, Uzma Afzal, Kijoung Song, Till Ittermann, Janina S. Ried, Allan Linneberg, Nicholas D. Hastie, Laticia Oozageer, Johanna Kuusisto, John Blangero, Amélie Bonnefond, Panos Deloukas, Andrew P. Morris, Oluf Pedersen, Adam E. Locke, Emmi Tikkanen, Veronique Vitart, Aki S. Havulinna, Olli T. Raitakari, Inga Prokopenko, Peter Lichtner, Harm-Jan Westra, Katja Borodulin, Teemu Kuulasmaa, Lars Lind, Bradford Towne, Christine G. Lee, Mika Kähönen, Anke W. Enneman, Terrence S. Furey, Treva Rice, Abbas Dehghan, Jaspal S. Kooner, Dabeeru C. Rao, Terrence Forrester, Jing Hua Zhao, Xin Li, Mary F. Feitosa, Melissa E. Garcia, Tian Liu, Aarno Palotie, Eric S. Orwoll, Reedik Mägi, Daniel S. Evans, Elisabeth Widen, Tim D. Spector, Caroline Hayward, Annette Peters, Markku Heliövaara, Harald Grallert, Niina Eklund, Robert C. Kaplan, Ilja Demuth, Luigi Ferrucci, Kati Kristiansson, Amy Luke, Tõnu Esko, Ken K. Ong, Gregory J. Tranah, Angelo Tremblay, Ben A. Oostra, Stefan Gustafsson, Zhihong Zhu, Nina Smolej Narančić, Cameron D. Palmer, William R. Scott, Alexander Teumer, Anne U. Jackson, Markus Perola, Toshiko Tanaka, Lavinia Paternoster, Henry Völzke, Terho Lehtimäki, Dominik Spira, Karin M. A. Swart, Louis Pérusse, Matthias Blüher, Jari Lahti, M. Carola Zillikens, Kari E. North, Yvonne Boettcher, Douglas P. Kiel, Bamidele O. Tayo, Elisabeth Steinhagen-Thiessen, Diana L. Cousminer, Joanne E. Curran, Peter Kovacs, David M. Evans, Claude Bouchard, Alena Stančáková, Seppo Koskinen, Jack W. Kent, Alexander W. Drong, Massimo Mangino, Frédéric Fumeron, Richard S. Cooper, Juha Karjalainen, Nathalie van der Velde, Martin L. Buchkovich, Stéphane Lobbens, Cristina Menni, Anubha Mahajan, Nele Friedrich, Anke Tönjes, Colin A. McKenzie, Tom Forsén, Anne E. Justice, Lisette C. P. G. M. de Groot, Ingrid B. Borecki, Mingfeng Zhang, Tommy Cederholm

Publikováno v: Nature Communications
Lu, Y, Day, F R, Gustafsson, S, Buchkovich, M L, Na, J, Bataille, V, Cousminer, D L, Dastani, Z, Drong, A W, Esko, T, Evans, D M, Falchi, M, Feitosa, M F, Ferreira, T, Hedman, Å K, Haring, R, Hysi, P G, Iles, M M, Justice, A E, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, J R B, Pers, T H, Qi, Q, Sanna, M, Schmidt, E M, Scott, W R, Shungin, D, Teumer, A, Vinkhuyzen, A A E, Walker, R W, Westra, H-J, Zhang, M, Zhang, W, Zhao, J H, Zhu, Z, Afzal, U, Ahluwalia, T S, Bakker, S J L, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, A S, Cederholm, T, Choh, A C, Choi, H J, Curran, J E, de Groot, L C P G M, De Jager, P L, Dhonukshe-Rutten, R A M, Enneman, A W, Eury, E, Evans, D S, Forsen, T, Friedrich, N, Fumeron, F, Garcia, M E, Gärtner, S, Han, B-G, Havulinna, A S, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, J W, Kolcic, I, Laatikainen, T, Lahti, J, Leach, I M, Lee, C G, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikaïnen, L-P, Medina-Gómez, C, Michaëlsson, K, Nalls, M, Nielson, C M, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, M A, Shin, C S, Narančić, N S, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, Y J, Swart, K M A, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, N M, Verweij, N, Wright, A F, Yu, L, Zmuda, J M, Eklund, N, Forrester, T, Grarup, N, Jackson, A U, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, C D, Ried, J S, Scott, R A, Stancáková, A, Wagner, P J, Demirkan, A, Döring, A, Gudnason, V, Kiel, D P, Kühnel, B, Mangino, M, McKnight, B, Menni, C, O'Connell, J R, Oostra, B A, Shuldiner, A R, Song, K, Vandenput, L, van Duijn, C M, Vollenweider, P, White, C C, Boehnke, M, Böttcher, Y, Cooper, R S, Forouhi, N G, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, McKenzie, C A, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, B O, Wareham, N J, Bennett, D A, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, N H, Cummings, S R, Czerwinski, S A, Demuth, I, Eckardt, R, Eriksson, J G, Ferrucci, L, Franco, O H, Froguel, P, Gansevoort, R T, Hansen, T, Harris, T B, Hastie, N, Heliövaara, M, Hofman, A, Jordan, J M, Jula, A, Kähönen, M, Kajantie, E, Knekt, P B, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, E S, Osmond, C, Perola, M, Pérusse, L, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Rivadeneira, F, Rudan, I, Salomaa, V, Sørensen, T I A, Stumvoll, M, Tönjes, A, Towne, B, Tranah, G J, Tremblay, A, Uitterlinden, A G, van der Harst, P, Vartiainen, E, Viikari, J S, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, J F, Yengo, L, Bishop, D T, Borecki, I B, Chambers, J C, Cupples, L A, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, T S, Franke, L, Han, J, Hunter, D J, Karjalainen, J, Karpe, F, Kaplan, R C, Kooner, J S, McCarthy, M I, Murabito, J M, Morris, A P, Bishop, J A N, North, K E, Ohlsson, C, Ong, K K, Prokopenko, I, Richards, J B, Schadt, E E, Spector, T D, Widén, E, Willer, C J, Yang, J, Ingelsson, E, Mohlke, K L, Hirschhorn, J N, Pospisilik, J A, Zillikens, M C, Lindgren, C, Kilpelaïnen, T O & Loos, R J F 2016, ' New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ', Nature Communications, vol. 7, 10495 . https://doi.org/10.1038/ncomms10495
Lu, Y, Day, F R, Gustafsson, S, Buchkovich, M L, Na, J, Bataille, V, Cousminer, D L, Dastani, Z, Drong, A W, Esko, T, Evans, D M, Falchi, M, Feitosa, M F, Ferreira, T, Hedman, Å K, Haring, R, Hysi, P G, Iles, M M, Justice, A E, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, J R B, Pers, T H, Qi, Q, Sanna, M, Schmidt, E M, Scott, W R, Shungin, D, Teumer, A, Vinkhuyzen, A A E, Walker, R W, Westra, H-J, Zhang, M, Zhang, W, Zhao, J H, Zhu, Z, Afzal, U, Ahluwalia, T S, Bakker, S J L, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, A S, Cederholm, T, Choh, A C, Choi, H J, Curran, J E, de Groot, L C P G M, De Jager, P L, Dhonukshe-Rutten, R A M, Enneman, A W, Eury, E, Evans, D S, Forsen, T, Friedrich, N, Fumeron, F, Garcia, M E, Gärtner, S, Han, B-G, Havulinna, A S, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, J W, Kolcic, I, Laatikainen, T, Lahti, J, Mateo Leach, I, Lee, C G, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikäinen, L-P, Medina-Gomez, C, Michaëlsson, K, Nalls, M A, Nielson, C M, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, M A, Shin, C S, Narančić, N S, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, Y J, Swart, K M A, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, N M, Verweij, N, Wright, A F, Yu, L, Zmuda, J M, Eklund, N, Forrester, T, Grarup, N, Jackson, A U, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, C D, Ried, J S, Scott, R A, Stancáková, A, Wagner, P J, Demirkan, A, Döring, A, Gudnason, V, Kiel, D P, Kühnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, J R, Oostra, B A, Shuldiner, A R, Song, K, Vandenput, L, van Duijn, C M, Vollenweider, P, White, C C, Boehnke, M, Boettcher, Y, Cooper, R S, Forouhi, N G, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, Mckenzie, C A, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, B O, Wareham, N J, Bennett, D A, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, N H, Cummings, S R, Czerwinski, S A, Demuth, I, Eckardt, R, Eriksson, J G, Ferrucci, L, Franco, O H, Froguel, P, Gansevoort, R T, Hansen, T, Harris, T B, Hastie, N, Heliövaara, M, Hofman, A, Jordan, J M, Jula, A, Kähönen, M, Kajantie, E, Knekt, P B, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, E S, Osmond, C, Perola, M, Pérusse, L, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Rivadeneira, F, Rudan, I, Salomaa, V, Sørensen, T I A, Stumvoll, M, Tönjes, A, Towne, B, Tranah, G J, Tremblay, A, Uitterlinden, A G, van der Harst, P, Vartiainen, E, Viikari, J S, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, J F, Yengo, L, Bishop, D T, Borecki, I B, Chambers, J C, Cupples, L A, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, T S, Franke, L, Han, J, Hunter, D J, Karjalainen, J, Karpe, F, Kaplan, R C, Kooner, J S, McCarthy, M I, Murabito, J M, Morris, A P, Bishop, J A N, North, K E, Ohlsson, C, Ong, K K, Prokopenko, I, Richards, J B, Schadt, E E, Spector, T D, Widén, E, Willer, C J, Yang, J, Ingelsson, E, Mohlke, K L, Hirschhorn, J N, Pospisilik, J A, Zillikens, M C, Lindgren, C, Kilpeläinen, T O & Loos, R J F 2016, ' New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ', Nature Communications, vol. 7, 10495 . https://doi.org/10.1038/ncomms10495
Nature Communications, 7:10495. Nature Publishing Group
Nature communications, 7. Nature Publishing Group
Nature Communications, 7. Nature Publishing Group
Lu, Y, Day, F R, Gustafsson, S, Buchkovich, M L, Na, J, Bataille, V, Cousminer, D L, Dastani, Z, Drong, A W, Esko, T, Evans, D M, Falchi, M, Feitosa, M F, Ferreira, T, Hedman, Å K, Haring, R, Hysi, P G, Iles, M M, Justice, A E, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, J R B, Pers, T H, Qi, Q, Sanna, M, Schmidt, E M, Scott, W R, Shungin, D, Teumer, A, Vinkhuyzen, A A E, Walker, R W, Westra, H-J, Zhang, M, Zhang, W, Zhao, J H, Zhu, Z, Afzal, U, Ahluwalia, T S, Bakker, S J L, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, A S, Cederholm, T, Choh, A C, Choi, H J, Curran, J E, de Groot, L C P G M, De Jager, P L, Dhonukshe-Rutten, R A M, Enneman, A W, Eury, E, Evans, D S, Forsen, T, Friedrich, N, Fumeron, F, Garcia, M E, Gärtner, S, Han, B-G, Havulinna, A S, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, J W, Kolcic, I, Laatikainen, T, Lahti, J, Mateo Leach, I, Lee, C G, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikäinen, L-P, Medina-Gomez, C, Michaëlsson, K, Nalls, M A, Nielson, C M, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, M A, Shin, C S, Narančić, N S, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, Y J, Swart, K M A, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, N M, Verweij, N, Wright, A F, Yu, L, Zmuda, J M, Eklund, N, Forrester, T, Grarup, N, Jackson, A U, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, C D, Ried, J S, Scott, R A, Stancáková, A, Wagner, P J, Demirkan, A, Döring, A, Gudnason, V, Kiel, D P, Kühnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, J R, Oostra, B A, Shuldiner, A R, Song, K, Vandenput, L, van Duijn, C M, Vollenweider, P, White, C C, Boehnke, M, Boettcher, Y, Cooper, R S, Forouhi, N G, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, M J, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, Mckenzie, C A, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, B O, Wareham, N J, Bennett, D A, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, N H, Cummings, S R, Czerwinski, S A, Demuth, I, Eckardt, R, Eriksson, J G, Ferrucci, L, Franco, O H, Froguel, P, Gansevoort, R T, Hansen, T, Harris, T B, Hastie, N, Heliövaara, M, Hofman, A, Jordan, J M, Jula, A, Kähönen, M, Kajantie, E, Knekt, P B, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, E S, Osmond, C, Perola, M, Pérusse, L, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Rivadeneira, F, Rudan, I, Salomaa, V, Sorensen, T, Stumvoll, M, Tönjes, A, Towne, B, Tranah, G J, Tremblay, A, Uitterlinden, A G, van der Harst, P, Vartiainen, E, Viikari, J S, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, J F, Yengo, L, Bishop, D T, Borecki, I B, Chambers, J C, Cupples, L A, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, T S, Franke, L, Han, J, Hunter, D J, Karjalainen, J, Karpe, F, Kaplan, R C, Kooner, J S, McCarthy, M I, Murabito, J M, Morris, A P, Bishop, J A N, North, K E, Ohlsson, C, Ong, K K, Prokopenko, I, Richards, J B, Schadt, E E, Spector, T D, Widén, E, Willer, C J, Yang, J, Ingelsson, E, Mohlke, K L, Hirschhorn, J N, Pospisilik, J A, Zillikens, M C, Lindgren, C, Kilpeläinen, T O & Loos, R J F 2016, ' New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ', Nature Communications, vol. 7, 10495 . https://doi.org/10.1038/ncomms10495
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Lu, Y, Day, F R, Gustafsson, S, Buchkovich, M L, Na, J, Bataille, V, Cousminer, D L, Dastani, Z, Drong, A W, Esko, T, Evans, D M, Falchi, M, Feitosa, M F, Ferreira, T, Hedman, Å K, Haring, R, Hysi, P G, Iles, M M, Justice, A E, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, J R B, Pers, T H, Qi, Q, Sanna, M, Schmidt, E M, Scott, W R, Shungin, D, Teumer, A, Vinkhuyzen, A A E, Walker, R W, Westra, H-J, Zhang, M, Zhang, W, Zhao, J H, Zhu, Z, Afzal, U, Ahluwalia, T S, Bakker, S J L, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, A S, Cederholm, T, Choh, A C, Choi, H J, Curran, J E, de Groot, L C P G M, De Jager, P L, Dhonukshe-Rutten, R A M, Enneman, A W, Eury, E, Evans, D S, Forsen, T, Friedrich, N, Fumeron, F, Garcia, M E, Gärtner, S, Han, B-G, Havulinna, A S, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, J W, Kolcic, I, Laatikainen, T, Lahti, J, Mateo Leach, I, Lee, C G, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikäinen, L-P, Medina-Gomez, C, Michaëlsson, K, Nalls, M A, Nielson, C M, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, M A, Shin, C S, Narančić, N S, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, Y J, Swart, K M A, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, N M, Verweij, N, Wright, A F, Yu, L, Zmuda, J M, Eklund, N, Forrester, T, Grarup, N, Jackson, A U, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, C D, Ried, J S, Scott, R A, Stancáková, A, Wagner, P J, Demirkan, A, Döring, A, Gudnason, V, Kiel, D P, Kühnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, J R, Oostra, B A, Shuldiner, A R, Song, K, Vandenput, L, van Duijn, C M, Vollenweider, P, White, C C, Boehnke, M, Boettcher, Y, Cooper, R S, Forouhi, N G, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, Mckenzie, C A, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, B O, Wareham, N J, Bennett, D A, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, N H, Cummings, S R, Czerwinski, S A, Demuth, I, Eckardt, R, Eriksson, J G, Ferrucci, L, Franco, O H, Froguel, P, Gansevoort, R T, Hansen, T, Harris, T B, Hastie, N, Heliövaara, M, Hofman, A, Jordan, J M, Jula, A, Kähönen, M, Kajantie, E, Knekt, P B, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, E S, Osmond, C, Perola, M, Pérusse, L, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Rivadeneira, F, Rudan, I, Salomaa, V, Sørensen, T I A, Stumvoll, M, Tönjes, A, Towne, B, Tranah, G J, Tremblay, A, Uitterlinden, A G, van der Harst, P, Vartiainen, E, Viikari, J S, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, J F, Yengo, L, Bishop, D T, Borecki, I B, Chambers, J C, Cupples, L A, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, T S, Franke, L, Han, J, Hunter, D J, Karjalainen, J, Karpe, F, Kaplan, R C, Kooner, J S, McCarthy, M I, Murabito, J M, Morris, A P, Bishop, J A N, North, K E, Ohlsson, C, Ong, K K, Prokopenko, I, Richards, J B, Schadt, E E, Spector, T D, Widén, E, Willer, C J, Yang, J, Ingelsson, E, Mohlke, K L, Hirschhorn, J N, Pospisilik, J A, Zillikens, M C, Lindgren, C, Kilpeläinen, T O & Loos, R J F 2016, ' New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ', Nature Communications, vol. 7, pp. 10495 . https://doi.org/10.1038/ncomms10495
Nature Communications, 7
Nature Communications, vol. 7, pp. 10495
Lu, Y, Day, F R, Gustafsson, S, Buchkovich, M L, Na, J, Bataille, V, Cousminer, D L, Dastani, Z, Drong, A W, Esko, T, Evans, D M, Falchi, M, Feitosa, M F, Ferreira, T, Hedman, A K, Haring, R, Hysi, P G, Iles, M M, Justice, A E, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Magi, R, Perry, J R B, Pers, T H, Qi, Q, Sanna, M, Schmidt, E M, Scott, W R, Shungin, D, Teumer, A, Vinkhuyzen, A A E, Walker, R W, Westra, H-J, Zhang, M, Zhang, W, Zhao, J H, Zhu, Z, Afzal, U, Ahluwalia, T S, Bakker, S J L, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, A S, Cederholm, T, Choh, A C, Choi, H J, Curran, J E, de Groot, L C P G M, De Jager, P L, Dhonukshe-Rutten, R A M, Enneman, A W, Eury, E, Evans, D S, Forsen, T, Friedrich, N, Fumeron, F, Garcia, M E, Gartner, S, Han, B-G, Havulinna, A S, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, J W, Kolcic, I, Laatikainen, T, Lahti, J, Leach, I M, Lee, C G, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikainen, L-P, Medina-Gomez, C, Michaelsson, K, Nalls, M A, Nielson, C M, Oozageer, L, Pascoe, L, Paternoster, L, Polasek, O, Ripatti, S, Sarzynski, M A, Shin, C S, Narancic, N S, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, Y J, Swart, K M A, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, N M, Verweij, N, Wright, A F, Yu, L, Zmuda, J M, Eklund, N, Forrester, T, Grarup, N, Jackson, A U, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Mannisto, S, Palmer, C D, Ried, J S, Scott, R A, Stancakova, A, Wagner, P J, Demirkan, A, Doring, A, Gudnason, V, Kiel, D P, Kuhnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, J R, Oostra, B A, Shuldiner, A R, Song, K, Vandenput, L, van Duijn, C M, Vollenweider, P, White, C C, Boehnke, M, Boettcher, Y, Cooper, R S, Forouhi, N G, Gieger, C, Grallert, H, Hingorani, A, Jorgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, Mckenzie, C A, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, B O, Wareham, N J, Bennett, D A, Bertram, L, Blangero, J, Bluher, M, Bouchard, C, Campbell, H, Cho, N H, Cummings, S R, Czerwinski, S A, Demuth, I, Eckardt, R, Eriksson, J G, Ferrucci, L, Franco, O H, Froguel, P, Gansevoort, R T, Hansen, T, Harris, T B, Hastie, N, Heliovaara, M, Hofman, A, Jordan, J M, Jula, A, Kahonen, M, Kajantie, E, Knekt, P B, Koskinen, S, Kovacs, P, Lehtimaki, T, Lind, L, Liu, Y, Orwoll, E S, Osmond, C, Perola, M, Perusse, L, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Rivadeneira, F, Rudan, I, Salomaa, V, Sorensen, T I A, Stumvoll, M, Tonjes, A, Towne, B, Tranah, G J, Tremblay, A, Uitterlinden, A G, van der Harst, P, Vartiainen, E, Viikari, J S, Vitart, V, Vohl, M-C, Volzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, J F, Yengo, L, Bishop, D T, Borecki, I B, Chambers, J C, Cupples, L A, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, T S, Franke, L, Han, J, Hunter, D J, Karjalainen, J, Karpe, F, Kaplan, R C, Kooner, J S, McCarthy, M I, Murabito, J M, Morris, A P, Bishop, J A N, North, K E, Ohlsson, C, Ong, K K, Prokopenko, I, Richards, J B, Schadt, E E, Spector, T D, Widen, E, Willer, C J, Yang, J, Ingelsson, E, Mohlke, K L, Hirschhorn, J N, Pospisilik, J A, Zillikens, M C, Lindgren, C, Kilpelainen, T O & Loos, R J F 2016, ' y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ', Nature Communications, vol. 7, 10495 . https://doi.org/10.1038/ncomms10495
Nature Communications 7 (2016)

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ecce342c6172985e54851035d00401
https://pubmed.ncbi.nlm.nih.gov/26833246