Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

Autor: Moustapha Kassem, Abdullah M. Alzahrani, Basem M. Abdallah

Publikováno v: Abdallah, B, Alzahrani, A M & Kassem, M 2018, ' Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway ', Bone, vol. 110, pp. 221-229 . https://doi.org/10.1016/j.bone.2018.02.018

Secreted Clusterin (sCLU, also known as Apolipoprotein J) is an anti-apoptotic glycoprotein involved in the regulation of cell proliferation, lipid transport, extracellular tissue remodeling and apoptosis. sCLU is expressed and secreted by mouse bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87a65599f7d54cacaef9ad69e0e2ae0
https://doi.org/10.1016/j.bone.2018.02.018

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

Autor: Ronni Nielsen, Qin Yan, Søren Fisker Schmidt, Jesper Grud Skat Madsen, Ann-Sofie B. Brier, Anne Loft, Susanne Mandrup, Zongzhi Liu, Hinrich Gronemeyer, Thomas Rosengren

Publikováno v: Brier, A-S B, Loft, A, Madsen, J G S, Nielsen, T R, Nielsen, R, Schmidt, S F, Liu, Z, Yan, Q, Gronemeyer, H & Mandrup, S 2017, ' The KDM 5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation ', Nucleic Acids Research, vol. 45, no. 4, pp. 1743-1759 . https://doi.org/10.1093/nar/gkw1156
Nucleic Acids Research
Nucleic Acids Research, 2017, 45 (4), pp.1743-1759. ⟨10.1093/nar/gkw1156⟩
Brier, A-S B, Loft, A, Madsen, J G S, Rosengren, T, Nielsen, R, Schmidt, S F, Liu, Z, Yan, Q, Gronemeyer, H & Mandrup, S 2017, ' The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation ', Nucleic Acids Research, vol. 45, no. 4, pp. 1743-1759 . https://doi.org/10.1093/nar/gkw1156

The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H3K4me3) mark frequently found at promoter regions of actively transcribed genes and is therefore generally considered to contribute to corepression. In this study, we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b380f9fbf249e5aaadef1d9bff8052a2
https://doi.org/10.1093/nar/gkw1156

Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds

Autor: Lars Porskjær Christensen, Rime Bahij El-Houri

Publikováno v: Christensen, L P & El-Houri, R B 2018, ' Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds ', Molecules, vol. 23, no. 10, 2431 . https://doi.org/10.3390/molecules23102431
Molecules, Vol 23, Iss 10, p 2431 (2018)
Christensen, L P & El-Houri, R 2018, ' Development of an in vitro screening platform for the identification of partial PPARγ agonists as a source for antidiabetic lead compounds ', Molecules, vol. 23, no. 10, pp. 2431 . https://doi.org/10.3390/molecules23102431
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Type 2 diabetes (T2D) is a metabolic disorder where insulin-sensitive tissues show reduced sensitivity towards insulin and a decreased glucose uptake (GU), which leads to hyperglycaemia. Peroxisome proliferator-activated receptor (PPAR)γ plays an im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55705887b450f9db5781d945f84f39e6
https://vbn.aau.dk/ws/files/287290382/Molecules_2018_23_10_2431.pdf

Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase

Autor: Lukas Varga, Pirjo Nuutila, Wenfei Sun, Sven Enerbäck, Patrik Stefanicka, Christian Wolfrum, Walter Wahli, Bettina Tall, Nicola Zamboni, Kirsi A. Virtanen, Elke Kiehlmann, Petra Krznar, Ez-Zoubir Amri, Lennart Opitz, Jozef Ukropec, Miroslav Balaz, Matthias Rosenwald, Martin E. Lidell, David Lasar

Publikováno v: Cell Reports, Vol 22, Iss 3, Pp 760-773 (2018)
Cell reports, vol. 22, no. 3, pp. 760-773
Cell Reports
Cell Reports, Elsevier Inc, 2018, 22 (3), pp.760-773. ⟨10.1016/j.celrep.2017.12.067⟩

Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fadae36002f7d671d892f2be877c3cd
https://pubmed.ncbi.nlm.nih.gov/29346772

Integrator complex plays an essential role in adipose differentiation

Autor: Otani, Y., Nakatsu, Y., Sakoda, H., Fukushima, Toshiaki, Fujishiro, M., Kushiyama, A., Okubo, H., Tsuchiya, Y., Ohno, H., Takahashi, S., Nishimura, F., Kamata, H., Katagiri, H., Asano, T.

Publikováno v: Biochemical and Biophysical Research Communications. 434:197-202

The dynamic process of adipose differentiation involves stepwise expressions of transcription factors and proteins specific to the mature fat cell phenotype. In this study, it was revealed that expression levels of IntS6 and IntS11, subunits of the I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c248139b83614fe3df86f7ccaa2e80
https://doi.org/10.1016/j.bbrc.2013.03.029