Výsledky vyhledávání - "Adina Fiebig"

Akademický článek

The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C

Autor: Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki

Publikováno v: Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)

Abstract Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclini

Externí odkaz: https://doaj.org/article/b688d5f6f21b43c69fa8ffaf7d1c4143

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Akademický článek

Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells

Autor: Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Marcus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N. Lode, Nadja Engel, Thomas Freitag, Carl Friedrich Classen, Claudia Maletzki

Publikováno v: Cell Death and Disease, Vol 13, Iss 6, Pp 1-14 (2022)

The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole fo

Externí odkaz: https://doaj.org/article/e4a237d57e9d4704bd9c0f69a431ba27

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HGG-13. Combined CDK inhibition and arginine-deprivation as targeted therapy for arginine-auxotrophic glioblastoma multiforme cells

Autor: Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Markus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N Lode, Nadja Engel, Carl Friedrich Classen, Claudia Maletzki

Publikováno v: Neuro-Oncology. 24:i62-i63

INTRODUCTION/BACKGROUND: Glioblastoma multiforme show constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy. This renders tumor cells vulnerable towards arginine-depleting substances, such as arginine deiminase from Strept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::686d1cc9bda3a10ab3f27c0a2b086190
https://doi.org/10.1093/neuonc/noac079.228

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