Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Adimoolam Narayanan"'
Publikováno v:
British Journal of Clinical Pharmacology
AIMS The aims of this study were to develop a pharmacokinetic (PK) and PK-pharmacodynamic (PK/PD) model of cinacalcet in adults and paediatrics with secondary hyperparathyroidism (SHPT) on dialysis, to test covariates of interest, and to perform simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26643ea8ecf159ebc090a8a31c01864c
https://doi.org/10.1111/bcp.13900
https://doi.org/10.1111/bcp.13900
Autor:
Juan Jose Perez-Ruixo, Isabelle Delor, Sameer Doshi, Andrew T. Chow, Murad Melhem, Per Olsson Gisleskog, Philippe Jacqmin, Bing-Bing Yang, John M. Harrold, Adimoolam Narayanan
Publikováno v:
Pharmaceutical Research
Purpose To model absolute neutrophil count (ANC) suppression in response to acute radiation (AR) exposure and evaluate ANC time course as a predictor of overall survival (OS) in response to AR exposure with or without treatment with granulocyte colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20242dca7166a771aa702a42b6d5d1bc
https://doi.org/10.1007/s11095-020-02839-3
https://doi.org/10.1007/s11095-020-02839-3
Autor:
Benjamin Wu, Murad Melhem, Ping Chen, Andrew T. Chow, Adimoolam Narayanan, John P. Gibbs, Per Olsson Gisleskog
Publikováno v:
Clinical Pharmacokinetics. 57:71-85
Etelcalcetide is a novel calcimimetic that binds and activates calcium-sensing receptors (CaSRs) for the treatment of secondary hyperparathyroidism (SHPT). To assess titrated dosing regimens, population pharmacokinetic (PK) and PK/pharmacodynamic (PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda5314b7982f75f4ef97a63c5f00e07
https://doi.org/10.1007/s40262-017-0550-4
https://doi.org/10.1007/s40262-017-0550-4
Autor:
Jim J. Xiao, Adimoolam Narayanan, P Olsson Gisleskog, Murad Melhem, Ping Chen, Juan Jose Perez-Ruixo, Justin J. Wilkins, John P. Gibbs
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 5:484-494
Etelcalcetide is a novel calcimimetic in development for the treatment of secondary hyperparathyroidism (SHPT). A population pharmacokinetic/pharmacodynamic (PK/PD) model was developed relating etelcalcetide exposures to markers of efficacy (parathyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c293306a6c0eff34b81da77015cea3f1
https://doi.org/10.1002/psp4.12106
https://doi.org/10.1002/psp4.12106
Autor:
Juan Jose Perez Ruixo, Ping Chen, Thuy Vu, Barbara A. Sullivan, Winnie Sohn, Andrew A. Welcher, Michael Boedigheimer, David Martin, Adimoolam Narayanan, Peiming Ma, Jin Wang
Publikováno v:
Pharmaceutical Research. 32:640-653
To investigate the relationships between AMG 811 exposure, concentration changes in serum IFN-γ, and IFN-γ-induced protein 10 (CXCL10), and to identify important contributions of baseline covariates to these relationships. A mechanism based pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81206946676d57f3e1468d5e40e177f0
https://doi.org/10.1007/s11095-014-1492-2
https://doi.org/10.1007/s11095-014-1492-2
Autor:
Marta Starcevic, Christopher Banfield, Alex Colbert, Peiming Ma, Cynthia Sung, Michael S. Vincent, Shao-Lee Lin, Tarundeep Kakkar, Thuy Vu, Leonid Gibiansky, Adimoolam Narayanan, Sarah A Hoofring
Publikováno v:
Pharmaceutical Research. 28:2530-2542
For AMG 317, a fully human monoclonal antibody to interleukin receptor IL-4Rα, we developed a population pharmacokinetic (PK) model by fitting data from four early phase clinical trials of intravenous and subcutaneous (SC) routes simultaneously, inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bcdd788ee1c518f64c8bc0a709322a
https://doi.org/10.1007/s11095-011-0481-y
https://doi.org/10.1007/s11095-011-0481-y
Autor:
Deanna Mohn, George Doellgast, Kameswara Rao V. Kuchimanchi, Tom Horan, Gerald Siu, Mark E. Dalphin, Frederick W. Jacobsen, Michelle Horner, Helen Kim, Wenyan D. Shen, Daniela Metz, Liana Zhang, Rohini Deshpande, Ming Zhang, James B. Chung, Adimoolam Narayanan
Publikováno v:
European Journal of Pharmacology. 610:110-118
The ICOS (Inducible T cell Co-Stimulator)/B7RP-1 (B7-related protein 1) interaction is critical for the proper activation of a T lymphocyte. In this manuscript we describe a systematic in vivo approach to determine the level of blockade required to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1211ea9af5416b36a6220acaed38d62d
https://doi.org/10.1016/j.ejphar.2009.03.023
https://doi.org/10.1016/j.ejphar.2009.03.023
Autor:
Peiming Ma, Rachelle D. Rodriguez, Liviawati Sutjandra, Andrew T. Chow, Mark Peterson, Bing-Bing Yang, Yow-Ming Wang, Adimoolam Narayanan
Publikováno v:
Journal of clinical pharmacology. 49(10)
Panitumumab is a fully human monoclonal antibody targeted to the extracellular domain of human epidermal growth factor receptor (EGFR). A comprehensive population pharmacokinetic model of panitumumab was developed using nonlinear mixed-effects modeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96154e24710228caffa4f7e0ef1e892b
https://pubmed.ncbi.nlm.nih.gov/19723673
https://pubmed.ncbi.nlm.nih.gov/19723673