Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Adil S.A. Al Hinai"'
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Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia
Autor: Tim Grob, Annelieke Zeilemaker, Melissa Rijken, Kirsten van Lom, Claudia A.J. Erpelinck-Verschueren, Mathijs A. Sanders, François G. Kavelaars, Peter J. M. Valk, Adil S.A. Al Hinai, Kirsten J. Gussinklo
Publikováno v: Leukemia, 34(8), 2220-2224. Nature Publishing Group
Acute myeloid leukemia (AML) is a heterogeneous disease with a great variety of somatic driver mutations. Each AML carries specific (combinations of) acquired mutations, which enables minimal residual disease (MRD) detection in virtually every patien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d5456292c6b52c20e1800ad236b0e9
https://doi.org/10.1038/s41375-020-0744-x
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5
MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML
Autor: Annelieke Zeilemaker, Marnie E. Blewitt, Stefan Fröhling, Remco Hoogenboezem, Christoffer Flensburg, Edward Chew, Mathijs A. Sanders, Ian J. Majewski, François G. Kavelaars, Melissa Rijken, Tamara J. McLennan, Andrew W. Roberts, Bram Luiken, Ashish Bajel, Sarah E. Miller, Adil S.A. Al Hinai, Eric M.J. Bindels, Warren S. Alexander, Peter J. M. Valk, Bob Löwenberg
Publikováno v: Blood, 132(14), 1526-1534. American Society of Hematology
The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a major role in shaping the human genome, and this methylation damage remains the primary source of somatic mutations that accumulate with age. How 5mC deamination cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9d7820dd3c17382a4fbcf97ead87dd
https://hdl.handle.net/1765/114238
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7
RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemia
Autor: Kirsten van Lom, François G. Kavelaars, Adil S.A. Al Hinai, Peter J. M. Valk, Annelieke Zeilemaker, Saman Abbas, Mathijs A. Sanders, H. Berna Beverloo
Publikováno v: Haematologica, 100(1), E1-E3. Ferrata Storti Foundation
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are heterogeneous malignancies characterized by a variety of acquired genetic abnormalities and variable response to treatment.[1][1],[2][2] In the last decade, a number of novel molecul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14b0fed089bc7772c12ba1bbb268eee
https://hdl.handle.net/1765/83841
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8
Abstract 1366: MBD4 guards against DNA damage from methylcytosine deamination
Autor: Sarah E. Miller, Bob Löwenberg, Melissa Rijken, Warren S. Alexander, Tamara J. McLennan, Ian J. Majewski, François G. Kavelaars, Mathijs A. Sanders, Andrew W. Roberts, Christoffer Flensburg, Peter J. M. Valk, Annelieke Zeilemaker, Remco Hoogenboezem, Marnie E. Blewitt, Eric M.J. Bindels, Bram Luiken, Edward Chew, Ashish Bajel, Adil S.A. Al Hinai
Publikováno v: Cancer Research. 78:1366-1366
Spontaneous methylcytosine (5mC) deamination is a common source of cytosine to thymine (C>T) mutations. These mutations accumulate over time, serving as a “molecular clock” that tracks cellular age. MBD4 is a thymine glycosylase that recognises s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1aa755e21bbd0f7319282dffe142e81
https://doi.org/10.1158/1538-7445.am2018-1366
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9
DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway
Autor: Adil S.A. Al Hinai, Melissa Rijken, Annelieke Zeilemaker, Bob Löwenberg, Peter J. M. Valk, Mathijs A. Sanders, François G. Kavelaars, Remco Hoogenboezem, Eric M.J. Bindels
Publikováno v: Blood. 128:1076-1076
Clonal hematopoiesis of indeterminate potential (CHIP) is a clonal disorder characterized by preleukemic mutations and increases in prevalence during aging. Infrequently CHIP progresses to hematological cancer implying that preleukemic mutations subt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83dbaa9e3ddd72f75ae400de1d608908
https://doi.org/10.1182/blood.v128.22.1076.1076
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