Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma

Autor: David Shih, Cynthia Hawkins, Thomas Hielscher, David T.W. Jones, Sidney Croul, Michael D. Taylor, Stefan M. Pfister, Marcel Kool, A. Sorana Morrissy, Xin Wang, Shing Hei Zhan, Adrian M. Dubuc, Vijay Ramaswamy, Rajeev Vibhakar, Paul A. Northcott, Hendrik Witt, Charles G. Eberhart, Steven J.M. Jones, Maria Mendez-Lago, Adi Rolider, Alexander Unterberger, Marc Remke, James T. Rutka, Andrey Korshunov, John Peacock, William A. Weiss, Marco A. Marra

Publikováno v: Acta neuropathologica, vol 125, iss 3

Recent sequencing efforts have described the mutational landscape of the pediatric brain tumor medulloblastoma. Although MLL2 is among the most frequent somatic single nucleotide variants (SNV), the clinical and biological significance of these mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96776baf50c055e07a2a8644c55b6b5d
https://doi.org/10.1007/s00401-012-1070-9

Divergent clonal selection dominates medulloblastoma at recurrence

Autor: Yaron S.N. Butterfield, David Shih, Janet C. Lindsey, Olivier Ayrault, James T. Rutka, Carlos Gilberto Carlotti, Borja L. Holgado, Livia Garzia, Ji Yeoun Lee, Paul A. Northcott, Laura K. Donovan, K. A. Michealraj, Vijay Ramaswamy, Toshihiro Kumabe, Nada Jabado, Thomas Zeng, Michael A. Grotzer, Michael D. Taylor, Jessica Liu, Darlene Lee, Eric Chuah, Gudrun Fleischhack, Scott Zuyderduyn, Xi Huang, Andrey Korshunov, Jacqueline E. Schein, Steven C. Clifford, Ute Bartels, V. Peter Collins, Peter B. Dirks, Stuart Matan-Lithwick, Claudia C. Faria, Daniel W. Fults, Xiao-Nan Li, Tobey J. MacDonald, Yusanne Ma, Mikhail Bilenky, Inanc Birol, Gary D. Bader, Nina Thiessen, Anne Bendel, Marc Remke, Eloi Mercier, Alex Manno, Haiyan I. Li, William A. Weiss, Stéphanie Puget, Noreen Dhalla, Marco A. Marra, Wendy J. Ingram, Sohrab P. Shah, Stefan M. Pfister, Ulrich Schüller, José Pimentel, Jaroslav Sterba, Marcel Kool, Ronald L. Hamilton, Lei Qin, Seung-Ki Kim, An He, Trevor J. Pugh, Stephen C. Mack, Kory Zayne, Xin Wang, Yoon Jae Cho, Kyu-Chang Wang, Patryk Skowron, Betty Luu, Ian F. Pollack, Cynthia Hawkins, Erwin G. Van Meir, Salomeh Jelveh, Andrew J. Mungall, Caitlin Hoffman, Andrew W. Walter, Helen Wheeler, Adi Rolider, Young Cheng, Michael K. Cooper, A. Sorana Morrissy, Jüri Reimand, Uri Tabori, Michael Mayo, Hamza Farooq, Florence M.G. Cavalli, Maria Luisa Garrè, Eric Bouffet, Adrian Ally, Richard A. Moore, Yongjun Zhao, Duncan Stearns, William Long, Richard Corbett, Karel Zitterbart, Yisu Li, Jeffrey H. Wisoff, Tina Wong, Robert J. Wechsler-Reya, Simon Bailey, Yuan Yao Thompson, Lara S. Collier, Luca Massimi, Andrew R. Hallahan, Byung Kyu Cho, Torsten Pietsch, David Lyden, Teiji Tominaga, Angela Tam, James Garvin, Roger J. Packer, John Peacock, Jeffrey J. Olson, Karey Shumansky, Adam J. Dupuy, Kane Tse, David A. Largaespada, Sandra E. Dunn, David T.W. Jones, Young Shin Ra, Patricia Lindsay, Tarek Shalaby, Rebecca Carlsen, Patrick Plettner, Andrew Roth, Chelsea Mayoh, Karen Mungall, Charles G. Eberhart, Xiaochong Wu, Daniela Pretti da Cunha Tirapelli, Sofia Nunes, Jenny Q. Qian, David Malkin, Maura Massimino, John J.Y. Lee, Steven J.M. Jones, Stephan Tippelt, Carolina Nor, Noriyuki Kijima

Publikováno v: Nature. 529(7586)

The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c59843844c6d06e9049c9cec0e69a2f
https://pubmed.ncbi.nlm.nih.gov/26831182

Regulation of Expression of Scaffoldin-Related Genes in Clostridium thermocellum

Autor: Tali W. Dror, Yuval Shoham, Adi Rolider, Raphael Lamed, Edward A. Bayer

Publikováno v: Journal of Bacteriology. 185:5109-5116

Clostridium thermocellum produces an extracellular multienzyme complex, termed the cellulosome, that allows efficient solubilization of crystalline cellulose. The complex is organized around a large noncatalytic protein subunit, termed CipA or scaffo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27fb3067091b70791943845b0135a83
https://doi.org/10.1128/jb.185.17.5109-5116.2003

Cytogenetic Prognostication Within Medulloblastoma Subgroups

Autor: Franck Bourdeaut, Michael K. Cooper, Almos Klekner, Stefan Rutkowski, David Shih, Jeffrey R. Leonard, Simon Bailey, Concezio Di Rocco, Ulrich Schüller, Giuseppe Cinalli, Pim J. French, Cinzia Lavarino, Young Shin Ra, John Peacock, Yuan Yao, A. Sorana Morrissy, William A. Weiss, Nanne K. Kloosterhof, László Bognár, Pasqualino De Antonellis, Teiji Tominaga, Stephen W. Scherer, Paul A. Northcott, David T.W. Jones, Reid C. Thompson, Shenandoah Robinson, Marta Perek-Polnik, Boleslaw Lach, Massimo Zollo, Olivier Delattre, Jennifer A. Chan, Janet C. Lindsey, Xin Wang, Nada Jabado, Karel Zitterbart, David Malkin, Adi Rolider, Roger J. Packer, James M. Olson, Steffen Albrecht, Ji Yeoun Lee, Wiesława Grajkowska, Charles G. Eberhart, Marcel Kool, Vijay Ramaswamy, Seung-Ki Kim, Joanna J. Phillips, Andrey Korshunov, Michael D. Taylor, Florence M.G. Cavalli, Luca Massimi, Xiaochong Wu, Maryam Fouladi, Peter Hauser, Xing Fan, Steven C. Clifford, Leos Kren, Carmen de Torres, Erna M.C. Michiels, Adrian M. Dubuc, Amar Gajjar, Livia Garzia, Eric Bouffet, Ian F. Pollack, Marc Remke, Jaume Mora, Claudia C. Faria, Miklós Garami, Erwin G. Van Meir, Byung Kyu Cho, Karin M. Muraszko, Joshua B. Rubin, Anne Jouvet, Stefan M. Pfister, Nalin Gupta, Johan M. Kros, Shin Jung, Yoon Jae Cho, Rajeev Vibhakar, Linda M. Liau, Stephen C. Mack, Scott L. Pomeroy, Betty Luu, Cynthia Hawkins, Ali G. Saad, Kyu-Chang Wang, Uri Tabori, Michelle Fèvre-Montange, Adam M. Fontebasso, Robert J. Wechsler-Reya, Toshihiro Kumabe, James T. Rutka, François Doz

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 32, iss 9
Journal of Clinical Oncology, 32(9), 886-+. American Society of Clinical Oncology

Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b446bdc999aa43ff7dd6176c0e742a
http://hdl.handle.net/11588/577671

Cytogenetic prognostication within medulloblastoma subgroups.

Autor: Shih DJ; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Bourdeaut F, Delattre O, Doz FF, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2014 Mar 20; Vol. 32 (9), pp. 886-96. Date of Electronic Publication: 2014 Feb 03.