Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Adi Rogel"'
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
Autor:
Rambabu N. Reddi, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, Roni Oren, Keren David, Jingjing Liu, Shirly Duberstein, Maxim Itkin, Sergey Malitsky, Haim Barr, Ben-Zion Katz, Yair Herishanu, Idit Shachar, Ziv Shulman, Nir London
Publikováno v:
Journal of the American Chemical Society. 145:3346-3360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f436a11b4b6322b7627191f360644f7
https://doi.org/10.1021/jacs.2c08853
https://doi.org/10.1021/jacs.2c08853
Autor:
Amnon Horovitz, Itai Bloch, Maayan Gal, Nir London, Rivkah Rogawski, Adi Rogel, Michal Sharon
Publikováno v:
Angewandte Chemie (International Ed. in English)
Understanding protein–ligand interactions in a cellular context is an important goal in molecular biology and biochemistry, and particularly for drug development. Investigators must demonstrate that drugs penetrate cells and specifically bind their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d151b7646e1b8d29981a8a396812c5a
http://europepmc.org/articles/PMC8457057
http://europepmc.org/articles/PMC8457057
Autor:
Ronen Gabizon, Rambabu N. Reddi, Nir London, Adi Rogel, Ziv Shulman, Neta Gurwicz, Efrat Resnick, Daniel Zaidman, Kim Goldenberg, Alexander Plotnikov, Haim Barr, Boddu Venkateswara Rao
Publikováno v:
Journal of the American Chemical Society
Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b35a6999ef3db842ab801d897fa66f
https://doi.org/10.1021/jacs.0c10644
https://doi.org/10.1021/jacs.0c10644
Autor:
Sirano Dhe-Paganon, Benika J. Pinch, Mark W. Zimmerman, Richa B. Shah, Kun Ping Lu, Jarrod A. Marto, Shuning He, Eriko Koide, Daniel Zaidman, Christopher M. Browne, Ziv Shulman, Barbara Martins da Costa, Christian Dubiella, Evon Poon, Guillaume Adelmant, Nir London, Xiao Zhen Zhou, Chu Wang, Ellen M. Langer, Kazuhiro Koikawa, Theresa D. Manz, Thomas Look, Xiaolan Lian, Hyuk-Soo Seo, Annan Yang, Louis Chesler, Ezekiel A. Geffken, Liat Stoler-Barak, Shin Kibe, Efrat Resnick, Nicholas E. Vangos, Shabnam Sharifzadeh, Shingo Kozono, Colin J. Daniel, Scott B. Ficarro, Roni Oren, Ying Chen, Nathanael S. Gray, Rosalie C. Sears, Samuel Sidi, Adi Rogel, Zainab M. Doctor, Behnam Nabet, Yann Jamin
Publikováno v:
Nat Chem Biol
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8338cdca0db7efbd0dc3ed699641997f
https://pubmed.ncbi.nlm.nih.gov/34040180
https://pubmed.ncbi.nlm.nih.gov/34040180