Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Adi Barokas"'
Autor:
Jason D. Galpin, Gabriel Leprivier, Dagmar E. Ehrnhoefer, Syam Prakash Somasekharan, Christopher A. Ahern, Liheng Li, Joan Mathers, Roberto Nitsch, Christopher J. Carnie, Sonia Franciosi, Barak Rotblat, Martina Metzler, Amber L. Southwell, Mads Daugaard, Tiffany Tang, Brian Kwok, Yu Deng, Gerry Melino, Niels H. Skotte, Dieter Fink, Adi Barokas, Naniye Malli Cetinbas, Josef M. Penninger, Michael R. Hayden, Poul H. Sorensen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(8)
Oxidative stress plays a key role in late onset diseases including cancer and neurodegenerative diseases such as Huntington disease. Therefore, uncovering regulators of the antioxidant stress responses is important for understanding the course of the
Autor:
Brian Kwok, Stephanie Smith, Michael Pollak, Sameer Agnihotri, Gaëlle Bridon, Amal El-Naggar, Michael D. Taylor, Christopher G. Proud, Mary Bowden, Marcel Kool, Marc Remke, Ye Wang, Syam Prakash Somasekharan, Xiaochong Wu, Bin Yu, Poul H. Sorensen, Thomas Hielscher, Andrey Korshunov, Abigail Rachele F. Mateo, Adi Barokas, Martin E. Gleave, Christopher A. Ahern, Jason D. Galpin, Russell G. Jones, Gabriel Leprivier, Joan Mathers, Adrian M. Dubuc, Paul A. Northcott, Brandon Faubert, Ryan Thomas, Stefan M. Pfister, Cristina E. Tognon, W. Brent Derry, V. Peter Collins, Martin G. McCabe, Amy Li, Olivier Delattre, Eric Jan, Barak Rotblat
Publikováno v:
Leprivier, G, Remke, M, Rotblat, B, Dubuc, A, Mateo, A R F, Kool, M, Agnihotri, S, El-Naggar, A, Yu, B, Somasekharan, S P, Faubert, B, Bridon, G, Tognon, C E, Mathers, J, Thomas, R, Li, A, Barokas, A, Kwok, B, Bowden, M, Smith, S, Wu, X, Korshunov, A, Hielscher, T, Northcott, P A, Galpin, J D, Ahern, C A, Wang, Y, Mccabe, M, Collins, V P, Jones, R G, Pollak, M, Delattre, O, Gleave, M E, Jan, E, Pfister, S M, Proud, C G, Derry, W B, Taylor, M D & Sorensen, P H 2013, ' The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation ', Cell, vol. 153, no. 5, pp. 1064–1079 . https://doi.org/10.1016/j.cell.2013.04.055
Leprivier, G, Remke, M, Rotblat, B, Dubuc, A, Mateo, A R F, Kool, M, Agnihotri, S, El-Naggar, A, Yu, B, Somasekharan, S P, Faubert, B, Bridon, G, Tognon, C E, Mathers, J, Thomas, R, Li, A, Barokas, A, Kwok, B, Bowden, M, Smith, S, Wu, X, Korshunov, A, Hielscher, T, Northcott, P A, Galpin, J D, Ahern, C A, Wang, Y, Mccabe, M, Collins, V P, Jones, R G, Pollak, M, Delattre, O, Gleave, M E, Jan, E, Pfister, S M, Proud, C G, Derry, W B, Taylor, M D & Sorensen, P H 2013, ' The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation ', Cell, vol. 153, no. 5, pp. 1064–1079 . https://doi.org/10.1016/j.cell.2013.04.055, https://doi.org/10.1016/j.cell.2013.04.055
Leprivier, G, Remke, M, Rotblat, B, Dubuc, A, Mateo, A R F, Kool, M, Agnihotri, S, El-Naggar, A, Yu, B, Somasekharan, S P, Faubert, B, Bridon, G, Tognon, C E, Mathers, J, Thomas, R, Li, A, Barokas, A, Kwok, B, Bowden, M, Smith, S, Wu, X, Korshunov, A, Hielscher, T, Northcott, P A, Galpin, J D, Ahern, C A, Wang, Y, Mccabe, M, Collins, V P, Jones, R G, Pollak, M, Delattre, O, Gleave, M E, Jan, E, Pfister, S M, Proud, C G, Derry, W B, Taylor, M D & Sorensen, P H 2013, ' The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation ', Cell, vol. 153, no. 5, pp. 1064–1079 . https://doi.org/10.1016/j.cell.2013.04.055, https://doi.org/10.1016/j.cell.2013.04.055
Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking t