Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

Autor: Xu W; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Billon C; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO (C.B., M.H., T.B.).; Center for Clinical Pharmacology, St Louis College of Pharmacy, Washington University School of Medicine, St Louis, MO (C.B., M.H., T.B.)., Li H; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Wilderman A; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Qi L; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Graves A; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Rideb JRDC; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Zhao Y; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Hayes M; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO (C.B., M.H., T.B.).; Center for Clinical Pharmacology, St Louis College of Pharmacy, Washington University School of Medicine, St Louis, MO (C.B., M.H., T.B.)., Yu K; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Losby M; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Hampton CS; Department of Pharmacology and Physiology, St Louis University School of Medicine, MO (C.S.H., C.M.A., J.K.W.)., Adeyemi CM; Department of Pharmacology and Physiology, St Louis University School of Medicine, MO (C.S.H., C.M.A., J.K.W.)., Hong SJ; McAllister Heart Institute (S.J.H., B.C.J.), University of North Carolina, Chapel Hill., Nasiotis E; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Fu C; Department of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA (C.F.).; University Hospitals Cleveland Medical Center, OH (C.F.)., Oh TG; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA (T.G.O., W.F., M.D., R.M.E.)., Fan W; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA (T.G.O., W.F., M.D., R.M.E.)., Downes M; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA (T.G.O., W.F., M.D., R.M.E.)., Welch RD; Biology and Chemistry Department, Blackburn College, Carlinville, IL (R.D.W.)., Evans RM; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA (T.G.O., W.F., M.D., R.M.E.)., Milosavljevic A; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.)., Walker JK; Department of Pharmacology and Physiology, St Louis University School of Medicine, MO (C.S.H., C.M.A., J.K.W.)., Jensen BC; McAllister Heart Institute (S.J.H., B.C.J.), University of North Carolina, Chapel Hill.; Department of Medicine, Division of Cardiology (B.C.J.), University of North Carolina, Chapel Hill., Pei L; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, and University of Pennsylvania, Philadelphia (L.P.)., Burris T; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO (C.B., M.H., T.B.).; Center for Clinical Pharmacology, St Louis College of Pharmacy, Washington University School of Medicine, St Louis, MO (C.B., M.H., T.B.)., Zhang L; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX (W.X., H.L., A.W., L.Q., A.G., J.R.D.C.R., Y.Z., K.Y., M.L., E.N., A.M., L.Z.).

Publikováno v: Circulation [Circulation] 2024 Jan 16; Vol. 149 (3), pp. 227-250. Date of Electronic Publication: 2023 Nov 14.

A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2.

Autor: Tsegay KB; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, United States., Adeyemi CM; St. Louis University School of Medicine, Department of Pharmacology and Physiology, St. Louis, MO, United States., Gniffke EP; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, United States., Sather DN; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.; Department of Pediatrics, University of Washington, Seattle, WA, United States., Walker JK; St. Louis University School of Medicine, Department of Pharmacology and Physiology, St. Louis, MO, United States.; Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University St. Louis, Seattle, WA, United States., Smith SEP; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, United States.; Department of Pediatrics, University of Washington, Seattle, WA, United States.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 Jun 14; Vol. 12, pp. 685308. Date of Electronic Publication: 2021 Jun 14 (Print Publication: 2021).

Synthesis and anti-parasitic activity of N-benzylated phosphoramidate Mg ²⁺ -chelating ligands.

Autor: Adeyemi CM; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa., Hoppe HC; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Isaacs M; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Mnkandhla D; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Lobb KA; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Klein R; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Kaye PT; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa. Electronic address: P.Kaye@ru.ac.za.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104280. Date of Electronic Publication: 2020 Sep 17.

Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives.

Autor: Adeyemi CM; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa., Conibear AC; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa., Mutorwa MK; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa., Nokalipa IC; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa., Isaacs M; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Mnkandhla D; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Hoppe HC; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Lobb KA; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Klein R; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Kaye PT; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa. Electronic address: p.kaye@ru.ac.za.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Aug; Vol. 101, pp. 103947. Date of Electronic Publication: 2020 May 16.