Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Adewale J. Ogunleye"'
Publikováno v:
F1000Research, Vol 10 (2021)
Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by genetic and epigenetic aberrations that alter the differentiation capacity of myeloid progenitor cells. The transcription factor CEBPα is frequently mutated in A
Externí odkaz:
https://doaj.org/article/6b67a564551f40819869c11fcaf11249
Autor:
Ekaterina I. Romanova, Anatoliy V. Zubritskiy, Anna V. Lioznova, Adewale J. Ogunleye, Vasily A. Golotin, Anna A. Guts, Andreas Lennartsson, Oleg N. Demidov, Yulia A. Medvedeva
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11413 (2022)
Acute myeloid leukemia (AML) is a rapidly progressing heterogeneous disease with a high mortality rate, which is characterized by hyperproliferation of atypical immature myeloid cells. The number of AML patients is expected to increase in the near fu
Externí odkaz:
https://doaj.org/article/845226ab7741478e8614482d364fd577
Molecular Docking, QSAR and Microscopic Studies of Anti-trypanosomal Compounds from the Pathogen Box
Publikováno v:
Current Computer-Aided Drug Design. 17:378-386
Background: Trypanosoma brucei (T. brucei) is the cause of the deadly human African trypanosomiasis (HAT) with a case fatality ratio of 10%. Objective: Targeting the essential Trypanosomal glucose metabolism pathway through the inhibition of phosphog
Autor:
Babatomiwa Kikiowo, Niyi S. Adelakun, Adewale J Ogunleye, Taiwo T. Ijatuyi, Wasiu O Alashe, Opeyemi Iwaloye
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 16:273-284
Background: Breast Cancer (BC), a common fatal disease and the deadliest cancer next to lung cancer, is characterized by an abnormal growth of cells in the tissues of the breast. BC chemotherapy is marked by targeting the activities of some receptors
Autor:
Ramon I Kanmodi, Faith O Oyende, Oluwafemi J Ogunmola, Peter G Ishola, Nekabari E Lugbe, Ahmed O Bello, Oluwamuyiwa T Amusan, Israel A Akinola, Gbemisola Morounke Saibu, Michael A Arowosegbe, Bimpe Folashade Ogungbe, Olaposi I Omotuyi, Segun Adeola, Sedoten O Ogun, O. B. Adu, Damilola C Ajayi, Adewale J Ogunleye, Patrick E Obasieke
Publikováno v:
Current Drug Discovery Technologies. 17:682-695
Background: P-21 activating kinase 4 (PAK4) is implicated in poor prognosis of many human tumors, particularly in Triple Negative Breast Cancer (TNBC) progression. Studies have revealed the crucial role of PAK4 in cell proliferation, anchorage-indepe
Autor:
Babatomiwa Kikiowo, Damilohun Samuel Metibemu, Oluwatoyin Olajide Oludoyi, Adewale J Ogunleye, Olaposi I Omotuyi, Taiwo T. Ijatuyi, Olumide K Inyang, Temitope Israel David, Niyi S. Adelakun
Publikováno v:
BioImpacts, Vol 10, Iss 4, Pp 227-234 (2020)
BioImpacts : BI
BioImpacts : BI
Introduction: Gout is a type of painful inflammation initiated by the interactions between monosodium urate crystals and connective tissue. Xanthine oxidase (XO) catalyzes the oxidation of hypoxanthine to xanthine, then to uric acid. The primary trea
Publikováno v:
Bioinformation
GSK3B has been an interesting drug target in the pharmaceutical industry. Its dysfunctional expression has prognostic significance in the top 3 cause of death associated with non-communicable diseases (cancer, Alzheimer's disease and type 2 diabetes)
Autor:
Adewale J Ogunleye, Olaposi I Omotuyi, Oluwatoba Emmanuel Oyeneyin, Gabriel O Eniafe, Yakubu O Adeniran, Joseph O Osunmuyiwa, Ojochenemi A Enejoh, Niyi S. Adelakun, Olumide K Inyang, Sidiqat A. Shodehinde, Damilohun Samuel Metibemu, Bamidele Adewumi
Publikováno v:
Bioinformation
Asthma is an inflammatory disease of the airway that poses a major threat to human health. With increase industrialization in the developed and developing countries, the incidence of asthma is on the rise. The β2-adrenergic receptor is an important
Autor:
Gabriel O Eniafe, Olaposi I Omotuyi, Adewale J Ogunleye, Damilohun Samuel Metibemu, Bamidele Adewumi, Olumide K Inyang
Publikováno v:
Journal of Analytical & Pharmaceutical Research. 6
Poly ADP ribose polymerase parp is a ubiquitous and transient nucleo protein with supra function in orchestrating DNA damage repair symphony and has prognostic value in small cell lung cancer SCLC Accumulating evidence indicate that the substrate NAD