IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children

Autor: Gabriela Samayoa-Reyes, Conner Jackson, Sidney Ogolla, Katherine Sabourin, Adeola Obajemu, Arlene E. Dent, Ludmilla Prokunina-Olsson, Rosemary Rochford

Publikováno v: Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021)

Abstract Background Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-TT allele are able

Externí odkaz: https://doaj.org/article/30beb292e3794a3eaec553b868d4bdb8

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

Autor: Olusegun O. Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M. Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang, Chen-Yang Shen, A. Rouf Banday, Thomas R. O’Brien, Zhibin Hu, Koichi Matsuda, Ludmila Prokunina-Olsson

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

IFNL3/IFNL4 polymorphisms are inversely associated with the risk of chronic hepatitis C virus (HCV) infection and cirrhosis, two major risk factors for developing hepatocellular carcinoma (HCC). To further explore these inverse associations and their

Externí odkaz: https://doaj.org/article/f0459e7d568f4786a7c64dbc64a7683f

Supplementary Figures from IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer

Autor: Stefan Ambs, Ludmila Prokunina-Olsson, Eric A. Klein, George R. Stark, Robert H. Silverman, Robert M. Stephens, Christopher A. Loffredo, Symone V. Jordan, Adeola Obajemu, Olusegun O. Onabajo, Tiffany H. Dorsey, Cristina Magi-Galluzzi, Ming Yi, Tiffany A. Wallace, Wei Tang

Supplementary Figure 1. Expression of IFNL4 after transfection of human prostate cancer cell lines with the IFNL4-Halo construct; Supplementary Figure 2. Expression of two interferon signatures, IRG and IRDS, in cultured prostate cancer epithelial ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bc3cca6b9ee19f5692105c66e2ed8c
https://doi.org/10.1158/1078-0432.22475357

Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

Autor: Krista A. Delviks-Frankenberry, Olusegun O. Onabajo, Seraph Han-Yin Lin, Vinay K. Pathak, Ariunaa Bayanjargal, Oscar Florez-Vargas, Joselin M. Vargas, Clara Zettelmeyer, Philippe Lamy, Lars Dyrskjøt, A. Rouf Banday, Adeola Obajemu, Ludmila Prokunina-Olsson

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology
Rouf Banday, A, Onabajo, O O, Lin, S H Y, Obajemu, A, Vargas, J M, Delviks-Frankenberry, K A, Lamy, P, Bayanjargal, A, Zettelmeyer, C, Florez-Vargas, O, Pathak, V K, Dyrskjøt, L & Prokunina-Olsson, L 2021, ' Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity ', Communications Biology, vol. 4, no. 1, 386 . https://doi.org/10.1038/s42003-021-01844-5

APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis. Identification of factors affecting the activity of these enzymes could help modulate mutagenesis and associated clinical outcomes. Here, we show that canonical and alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6031aa58382abe731ed6bd22683708
https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac9

IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children

Autor: Ludmila Prokunina-Olsson, Almahamoudou Mahamar, Adeola Obajemu, Patrick E. Duffy, Nathan Brand, Robert Morrison, Sam M. Mbulaiteye, Jennifer Kwan, Michelle Manning, Sungduk Kim, Youssoufa Sidibe, Oumar Attaher, Paul S. Albert, Oscar Florez-Vargas, Michal Fried, Olusegun O. Onabajo, Alassane Dicko, Amy Hutchinson

Publikováno v: Genes and Immunity
Genes and immunity, vol 22, iss 1

Genetic polymorphisms within the IFNL3/IFNL4 genomic region, which encodes type III interferons, have been strongly associated with clearance of hepatitis C virus. We hypothesized that type III interferons might be important for the immune response t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5984a960adcbd410785d532e3983f7
https://pubmed.ncbi.nlm.nih.gov/33850301