Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Adeola F. Adewola"'
Autor:
Adeola F. Adewola, Jose Oberholzer, Meirigeng Qi, Diana Gutierrez, Katie Kinzer, Joshua E. Mendoza-Elias, Yong Wang, Tricia A. Harvat, David T. Eddington, Dongyoung Lee
Publikováno v:
Biomedical Microdevices. 14:7-16
In this study, a new class of duplex microfluidic device is described that utilizes a dual perifusion network to simultaneously perform live-cell optical imaging of physiological activities and study insulin release kinetics on two islet populations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed471fedcf031b7fc0a5e1d0c2bd364
https://doi.org/10.1007/s10544-011-9580-0
https://doi.org/10.1007/s10544-011-9580-0
Autor:
Dongyoung Lee, Jose Oberholzer, David T. Eddington, Joe F. Lo, Meirigeng Qi, Adeola F. Adewola, Yong Wang, Tricia A. Harvat, Katie Kinzer, Joshua E. Mendoza-Elias
Publikováno v:
Bioanalysis. 2:1729-1744
β-cells respond to blood glucose by secreting insulin to maintain glucose homeostasis. Perifusion enables manipulation of biological and chemical cues in elucidating the mechanisms of β-cell physiology. Recently, microfluidic devices made of polydi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c334c445c979b5c0aa6c9f2bda9bad6
https://doi.org/10.4155/bio.10.131
https://doi.org/10.4155/bio.10.131
Autor:
Adeola F. Adewola, Dongyoung Lee, Shusen Wang, Jose Oberholzer, Tricia A. Harvat, Enrico Benedetti, Rafael A. Vega, Yong Wang, Merigeng Qi
Publikováno v:
Surgery. 148:858-866
Background Islet transplantation is an emerging therapy for type 1 diabetes mellitus with variable success. Molecular therapeutics is a promising approach to improve islet graft function and transplant outcomes. Traditional delivery vectors, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ff70249f8001a256c91acae897033a
https://doi.org/10.1016/j.surg.2010.07.036
https://doi.org/10.1016/j.surg.2010.07.036
Autor:
Yong Wang, David T. Eddington, Javeed Shaikh Mohammed, Jose Oberholzer, Tricia A. Harvat, Dongyoung Lee, Adeola F. Adewola
Publikováno v:
Biomedical Microdevices. 12:409-417
A microfluidic islet perifusion device was developed for the assessment of dynamic insulin secretion of multiple pancreatic islets and simultaneous fluorescence imaging of calcium influx and mitochondrial potential changes. The fanned out design of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583d8b8231a83c8dd07cdf4ec8870975
https://doi.org/10.1007/s10544-010-9398-1
https://doi.org/10.1007/s10544-010-9398-1
Autor:
Adeola F. Adewola, Jose Oberholzer, David T. Eddington, Shesun Wang, Wang Yong, Ki Hwan Nam, Tricia A. Harvat
Publikováno v:
Biomedical microdevices. 12(5)
Islet size has recently been demonstrated to be an important factor in determining human islet transplantation outcomes. In this study, a multi-layered microfluidic device was developed and quantified for size-based separation of a heterogeneous popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892aeef8dcadea3969257a030552717e
https://pubmed.ncbi.nlm.nih.gov/20549367
https://pubmed.ncbi.nlm.nih.gov/20549367
Autor:
Yong Wang, Tricia A. Harvat, David T. Eddington, Jose Oberholzer, Dongyoung Lee, Adeola F. Adewola
Publikováno v:
Journal of Visualized Experiments : JoVE
A microfluidic islet perifusion device was developed for the assessment of dynamic insulin secretion of multiple islets and simultaneous fluorescence imaging of calcium influx and mitochondrial potential changes. The device consists of three layers:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd0fb9eea28455c2fdc4734858ba0eb
https://doi.org/10.3791/1649
https://doi.org/10.3791/1649