The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Autor: Kara A. Bernstein, Hani S. Zaher, Tony M. Mertz, Thong T Luong, Sarah R. Hengel, Braulio Bonilla, Catherine A. Pressimone, Steven A. Roberts, Adeola A Fagunloye, Nima Mosammaparast, Kyle S Rapchak, Alexander J. Brown, Reagan A Russell, Ewa P. Malc, Debra Mitchell, Piotr A. Mieczkowski, Rudri K Vyas

Publikováno v: eLife, Vol 10 (2021)
eLife

Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25ae7714a354cd43ce89af9d832bcee
https://elifesciences.org/articles/68080

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

Autor: Hong L; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Braden DC; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Zhao Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA; School of Medicine, Tsinghua University, Beijing, China., Skoko JJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Chang F; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Woodcock SR; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Uvalle C; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Casey A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Wood K; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Salvatore SR; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Asan A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Harkness T; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Fagunloye A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA., Razzaghi M; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA., Straub A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Spies M; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA., Brown DD; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lee AV; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Schopfer F; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Freeman BA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA., Neumann CA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA. Electronic address: neumannc@upmc.edu.

Publikováno v: Redox biology [Redox Biol] 2023 Oct; Vol. 66, pp. 102856. Date of Electronic Publication: 2023 Aug 19.