Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Adenovirus E1B protein"'
Autor:
S. J. Flint, George Hung
Publikováno v:
Virology. 504:12-24
Several of the functions of the human adenovirus type 5 E1B 55 kDa protein are fulfilled via the virus-specific E3 ubiquitin ligase it forms with the viral E4 Orf6 protein and several cellular proteins. Important substrates of this enzyme have not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765599c513edf8f84d29ae7a6faf47a0
https://doi.org/10.1016/j.virol.2017.01.013
https://doi.org/10.1016/j.virol.2017.01.013
Publikováno v:
Journal of Virology. 90:497-505
Adenovirus 14p1 (Ad14p1) is an emergent variant of Ad serotype 14 (Ad14) that has caused increased severity of respiratory illnesses during globally distributed outbreaks, including cases of acute respiratory distress syndrome and death. We found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6205442260df9b70ecdb31fe33b08579
https://doi.org/10.1128/jvi.01790-15
https://doi.org/10.1128/jvi.01790-15
Publikováno v:
Viruses, Vol 7, Iss 11, Pp 5767-5779 (2015)
Viruses
Viruses
Various viruses have been studied and developed for oncolytic virotherapies. In virotherapy, a relatively small amount of viruses used in an intratumoral injection preferentially replicate in and lyse cancer cells, leading to the release of amplified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e4aea3f6ece783387a340c377054fb
https://doi.org/10.3390/v7112905
https://doi.org/10.3390/v7112905
Publikováno v:
Journal of Virology. 89:10260-10272
Adenovirus E4-ORF3 and E1B-55K converge in subverting critical overlapping cellular pathways to facilitate virus replication. Here, we show that E1B-55K and E4-ORF3 induce sumoylation and the assembly of SUMO2/3 viral genome replication domains. Usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3437979e80782d813d1558f4765d69
https://doi.org/10.1128/jvi.01091-15
https://doi.org/10.1128/jvi.01091-15
Autor:
Govind A. Shah, Clodagh C. O’Shea
Publikováno v:
Cell. 162:987-1002
SummaryIn response to cellular genome breaks, MRE11/RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication. Here, we show that MRN-ATM also has critical functions in defending the cell against DNA viruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4605b65de04d358d6255439e2a7895fe
https://doi.org/10.1016/j.cell.2015.07.058
https://doi.org/10.1016/j.cell.2015.07.058
Autor:
Kate J. Heesom, Andrew S. Turnell, David A. Matthews, Yen Rong Fu, Simon Davis, Vanessa C. Evans
Publikováno v:
Fu, Y R, Turnell, A S, Davis, S, Heesom, K J, Evans, V C & Matthews, D A 2017, ' Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics ', Journal of General Virology, vol. 98, no. 6, pp. 1377-1388 . https://doi.org/10.1099/jgv.0.000781
The Journal of General Virology
The Journal of General Virology
Adenovirus has evolved strategies to usurp host-cell factors and machinery to facilitate its life cycle, including cell entry, replication, assembly and egress. Adenovirus continues, therefore, to be an important model system for investigating fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9283c6d30a6e6c9a85e980577d0fe2cf
https://research-information.bris.ac.uk/ws/files/124621825/1377_vir000781.pdf
https://research-information.bris.ac.uk/ws/files/124621825/1377_vir000781.pdf
Publikováno v:
Cancer Biology & Therapy. 15:1358-1366
Oncolytic viruses have recently received widespread attention for their potential in innovative cancer therapy. Many telomerase promoter-regulated oncolytic adenoviral vectors retain E1A and E1B. However, the functions of E1A and E1B proteins in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed63318c81d3afe2c28d7931411b955
https://doi.org/10.4161/cbt.29842
https://doi.org/10.4161/cbt.29842
Publikováno v:
Virology. :205-219
Adenovirus inundates the productively infected cell with linear, double-stranded DNA and an abundance of single-stranded DNA. The cellular response to this stimulus is antagonized by the adenoviral E1B and E4 early genes. A mutant group C adenovirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1ab5676d8d0aa6dc8b7add490a89d2
Publikováno v:
British Journal of Cancer
Background: Conditionally replicating adenoviruses (CRAds) represent a novel class of oncological therapeutic agents. One strategy to ensure tumour targeting is to place the essential viral genes under the control of tumour-specific promoters. Ki67 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35ff11363431a469f866cf81d89dbf8
http://europepmc.org/articles/PMC4021521
http://europepmc.org/articles/PMC4021521
Publikováno v:
Journal of Virology. 88:2658-2669
Cells that undergo apoptosis in response to chemical or physical stimuli repress inflammatory reactions, but cells that undergo nonapoptotic death in response to such stimuli lack this activity. Whether cells dying from viral infection exhibit a cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f2976473e9e75a85a2b8032481033c
https://doi.org/10.1128/jvi.02372-13
https://doi.org/10.1128/jvi.02372-13