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Separate regions of an adenovirus E1B protein critical for different biological functions

Autor: Irene Mak, Stanley Mak

Publikováno v: Virology. 176(2)

The E1B region of Ad12 encodes two major proteins, the 482R (55K) and 163R (19K). In this report we showed that the E1B 482R is multifunctional, in that its structure may somehow contribute to its own stability, in viral DNA and virus replication, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63df1337066f3fe131ca298bb625f36
https://pubmed.ncbi.nlm.nih.gov/2140631

Low-Level Expression of the E1B 20-Kilodalton Protein by Adenovirus 14p1 Enhances Viral Immunopathogenesis

Autor: Jay R. Radke, Sherri L. Yong, James L. Cook

Publikováno v: Journal of Virology. 90:497-505

Adenovirus 14p1 (Ad14p1) is an emergent variant of Ad serotype 14 (Ad14) that has caused increased severity of respiratory illnesses during globally distributed outbreaks, including cases of acute respiratory distress syndrome and death. We found tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6205442260df9b70ecdb31fe33b08579
https://doi.org/10.1128/jvi.01790-15

Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains

Autor: Clodagh C. O’Shea, Jennifer M. Higginbotham

Publikováno v: Journal of Virology. 89:10260-10272

Adenovirus E4-ORF3 and E1B-55K converge in subverting critical overlapping cellular pathways to facilitate virus replication. Here, we show that E1B-55K and E4-ORF3 induce sumoylation and the assembly of SUMO2/3 viral genome replication domains. Usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3437979e80782d813d1558f4765d69
https://doi.org/10.1128/jvi.01091-15

Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics

Autor: Kate J. Heesom, Andrew S. Turnell, David A. Matthews, Yen Rong Fu, Simon Davis, Vanessa C. Evans

Publikováno v: Fu, Y R, Turnell, A S, Davis, S, Heesom, K J, Evans, V C & Matthews, D A 2017, ' Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics ', Journal of General Virology, vol. 98, no. 6, pp. 1377-1388 . https://doi.org/10.1099/jgv.0.000781
The Journal of General Virology

Adenovirus has evolved strategies to usurp host-cell factors and machinery to facilitate its life cycle, including cell entry, replication, assembly and egress. Adenovirus continues, therefore, to be an important model system for investigating fundam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9283c6d30a6e6c9a85e980577d0fe2cf
https://research-information.bris.ac.uk/ws/files/124621825/1377_vir000781.pdf