Výsledky vyhledávání - "Adenovirus Death Protein"

Akademický článek

Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Autor: Matthew Glen Robertson, Benjamin Bruce Eidenschink, Eriko Iguchi, Stanislav O. Zakharkin, Christopher J. LaRocca, Ezequiel J. Tolosa, Mark J. Truty, Kari Jacobsen, Martin E. Fernandez-Zapico, Julia Davydova

Publikováno v: Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 659-668 (2021)

Encoding the sodium iodide symporter (NIS) by an adenovirus (Ad) is a promising strategy to facilitate non-invasive imaging and radiotherapy of pancreatic cancer. However, insufficient levels of NIS expression in tumor cells have limited its clinical

Externí odkaz: https://doaj.org/article/a978dc28a1fd4f84b44bea3c49ac95a1

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Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Autor: Benjamin Bruce Eidenschink, Martin E. Fernandez-Zapico, Julia Davydova, Stanislav O. Zakharkin, Mark J. Truty, Eriko Iguchi, Christopher J. LaRocca, Ezequiel J. Tolosa, Kari Jacobsen, Matthew Glen Robertson

Publikováno v: Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 659-668 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da47342fabe61279825cbf9fa4b320d6
http://europepmc.org/articles/PMC7985464

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An oncolytic adenovirus 11p vector expressing adenovirus death protein in the E1 region showed significant apoptosis and tumour-killing ability in metastatic prostate cells

Autor: Ya-Fang Mei, Haidong Wu

Publikováno v: Oncotarget

// Haidong Wu 1 and Ya-Fang Mei 1, 2 1 Department of Clinical Microbiology, Virology, Umea University, Umea, Sweden 2 Laboratory Medicine, Clinical Microbiology, Umea University Hospital, Umea, Sweden Correspondence to: Ya-Fang Mei, email: ya-fang.me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c9718b06361dd611f748c17ec7c28
https://doi.org/10.18632/oncotarget.26754

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Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein

Autor: Søren Pfitzner, Jens B. Bosse, Helga Hofmann-Sieber, Felix Flomm, Rudolph Reimer, Thomas Dobner, Kay Grünewald, Linda E. Franken

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13034
International Journal of Molecular Sciences, Vol 22, Iss 13034, p 13034 (2021)

The human adenovirus type 5 (HAdV5) infects epithelial cells of the upper and lower respiratory tract. The virus causes lysis of infected cells and thus enables spread of progeny virions to neighboring cells for the next round of infection. The mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55c408ca94c50a413cb3b75f8ade3a4
http://europepmc.org/articles/PMC8657697

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The Adenovirus Death Protein – A small membrane protein controls cell lysis and disease

Autor: Fanny Georgi, Urs F. Greber

Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections are usually mild and controlled by humoral and cell-based immunity. Reactivation of persistently infected immune cells can lead to a life-threatening disease in i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a50ff23026297ee32880992b7465d03
https://doi.org/10.5167/uzh-188168

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Akademický článek

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The FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of human adenoviruses

Autor: Nicole Meili, Fanny Georgi, Luca Murer, Urs F. Greber, Robert Witte, Lisa Yu, Gerardo Turcatti, Artur Yakimovich, Melanie Grove, Vardan Andriasyan, Silvio Hemmi, Fabien Kuttler

Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. The human AdV (HAdV) species B and C, such as HAdV-C2, C5 and B14, cause respiratory disease, and constitute a health threat for immuno-compromised individuals. HAdV-Cs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56f026ef9d467cf38d23c149f0a77e81
https://doi.org/10.1101/2020.05.15.098061

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The genome position of a therapeutic transgene strongly influences the level of expression in an armed oncolytic human adenovirus vector

Autor: Joshua Del Papa, Ryan G. Clarkin, Kathy L. Poulin, Robin J. Parks

Publikováno v: Virology. 561

Efficacy of oncolytic, conditionally-replicating adenovirus (CRAd) vectors can be enhanced by “arming” the vector with therapeutic transgenes. We examined whether inclusion of an intact early region 3 (E3) and the reptilian reovirus fusogenic p14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb085ceb0f6df87a2987ccd032ebb86
https://pubmed.ncbi.nlm.nih.gov/34171766

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A compendium of adenovirus genetic modifications for enhanced replication, oncolysis, and tumor immunosurveillance in cancer therapy

Autor: Vladimir P. Chekhonin, A. A. Stepanenko

Publikováno v: Gene. 679:11-18

In this review, we specifically focus on genetic modifications of oncolytic adenovirus 5 (Ad5)-based vectors that enhance replication, oncolysis/spread, and virus-mediated tumor immunosurveillance. The finding of negative regulation of minor core pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cf6e39036335f018fa37ad7e304aa0
https://doi.org/10.1016/j.gene.2018.08.069

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