Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Autor: Matthew Glen Robertson, Benjamin Bruce Eidenschink, Eriko Iguchi, Stanislav O. Zakharkin, Christopher J. LaRocca, Ezequiel J. Tolosa, Mark J. Truty, Kari Jacobsen, Martin E. Fernandez-Zapico, Julia Davydova

Publikováno v: Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 659-668 (2021)

Encoding the sodium iodide symporter (NIS) by an adenovirus (Ad) is a promising strategy to facilitate non-invasive imaging and radiotherapy of pancreatic cancer. However, insufficient levels of NIS expression in tumor cells have limited its clinical

Externí odkaz: https://doaj.org/article/a978dc28a1fd4f84b44bea3c49ac95a1

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Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

Autor: Benjamin Bruce Eidenschink, Martin E. Fernandez-Zapico, Julia Davydova, Stanislav O. Zakharkin, Mark J. Truty, Eriko Iguchi, Christopher J. LaRocca, Ezequiel J. Tolosa, Kari Jacobsen, Matthew Glen Robertson

Publikováno v: Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 659-668 (2021)

Encoding the sodium iodide symporter (NIS) by an adenovirus (Ad) is a promising strategy to facilitate non-invasive imaging and radiotherapy of pancreatic cancer. However, insufficient levels of NIS expression in tumor cells have limited its clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da47342fabe61279825cbf9fa4b320d6
http://europepmc.org/articles/PMC7985464

Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein

Autor: Søren Pfitzner, Jens B. Bosse, Helga Hofmann-Sieber, Felix Flomm, Rudolph Reimer, Thomas Dobner, Kay Grünewald, Linda E. Franken

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13034
International Journal of Molecular Sciences, Vol 22, Iss 13034, p 13034 (2021)

The human adenovirus type 5 (HAdV5) infects epithelial cells of the upper and lower respiratory tract. The virus causes lysis of infected cells and thus enables spread of progeny virions to neighboring cells for the next round of infection. The mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55c408ca94c50a413cb3b75f8ade3a4
http://europepmc.org/articles/PMC8657697

The Adenovirus Death Protein – A small membrane protein controls cell lysis and disease

Autor: Fanny Georgi, Urs F. Greber

Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections are usually mild and controlled by humoral and cell-based immunity. Reactivation of persistently infected immune cells can lead to a life-threatening disease in i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a50ff23026297ee32880992b7465d03
https://doi.org/10.5167/uzh-188168