Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against animal African trypanosomiasis

Autor: Marzuq A. Ungogo, Mustafa M. Aldfer, Manal J. Natto, Hainan Zhuang, Robyn Chisholm, Katy Walsh, MarieClaire McGee, Kayhan Ilbeigi, Jamal Ibrahim Asseri, Richard J. S. Burchmore, Guy Caljon, Serge Van Calenbergh, Harry P. De Koning

Publikováno v: International journal of molecular sciences
Ungogo, M, Aldfer, M M, Natto, M J, Zhuang, H, Chisholm, R, Walsh, K, McGee, M, Ilbeigi, K, Asseri, J I, Burchmore, R J S, Caljon, G, Van Calenbergh, S & De Koning, H P 2023, ' Cloning and characterization of Trypanosoma congolense and T. vivax nucleoside transporters reveal the potential of P1-type carriers for the discovery of broad-spectrum nucleoside-based therapeutics against Animal African trypanosomiasis ', International Journal of Molecular Sciences, vol. 24, no. 4, 3144, pp. 1-34 . https://doi.org/10.3390/ijms24043144
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3144

African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan Africa. Treatment options are very limited and threatened by resistance. Tubercid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d698935a175e9aa8b037e5e91084ebd
https://repository.uantwerpen.be/docstore/d:irua:16921

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Ectopic mineralisation of the mandibular symphysis in ENT1 knockout mice: A model of dystrophic calcification

Autor: Patti K. Kiser, S. Jeffrey Dixon, Kim L. Beaucage, Ryan J. Beach, Cheryle A. Séguin, Dale E. Fournier

Publikováno v: Bone Reports, Vol 15, Iss, Pp 101100-(2021)
Paediatrics Publications

Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes. We reported previously that mice lacking ENT1 (ENT1−/−) exhibit progressive ectopic calcification of spinal tissues—a phenotype res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a72a9fb0128ab595db84ec9eae17d6
http://www.sciencedirect.com/science/article/pii/S2352187221003569

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

Autor: Paul M. O'Neill, Harry P. de Koning, Anna Dimitriou, Ulrich Zachariae, Joanna Wielinska, Arvind Kumar, Anthonius A. Eze, Mark C. Field, Chinyere E Okpara, Juan F. Quintana, Richard R. Tidwell, Simone Weyand, Luca Settimo, Siu Pui Ying Kelly, Christopher M Woodley, Dominik Gurvic, Ibrahim A. Teka, Mohammed I. Al-Salabi, Fredrik Svensson, Fabian Hulpia, Ali H. Alghamdi, Patrik Milic, Teresa Sprenger, Hasan M. S. Ibrahim, David W. Boykin, Laura Watson, Laura F Anderson, Daniel Paape, Mark Carrington, Maria Esther Martin Abril, Simon Gudin, Gustavo D. Campagnaro, Graeme Smart, Jane C. Munday, Christophe Dardonville

Publikováno v: ELIFE
eLife
eLife, Vol 9 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a8612e3af4438b62845ec7d02b257f
https://biblio.ugent.be/publication/8671473

Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models

Autor: Jeff Travis, Kevin Fitzgerald, Frederick Sannajust, Christopher P. Regan, Pierre Morissette, Hillary Regan

Publikováno v: Journal of Pharmacological and Toxicological Methods. 105:106817

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e3e3a3abda2a3efa1ab85a51a1c5195
https://doi.org/10.1016/j.vascn.2020.106817