Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Adenosine receptor binding"'
Autor:
Yağmur Özhan, Zhan-Guo Gao, Zafer Şahin, Leyla Yurttaş, Şeref Demirayak, Sevde Nur Biltekin, Barkın Berk, Hande Sipahi, Kenneth A. Jacobson
Publikováno v:
Eur J Med Chem
Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well known fragments for adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe0b76b26cb6e220b225ebbb4183035
https://europepmc.org/articles/PMC7880896/
https://europepmc.org/articles/PMC7880896/
Autor:
Ji-Youn Lee, Hunjoo Ha, Lak Shin Jeong, Dnyandev B. Jarhad, Chong-Woo Park, Gyudong Kim, Jinha Yu, Hyuk Woo Lee
Publikováno v:
Archives of Pharmacal Research. 42:773-779
Truncated 4'-thionucleosides 1-4 and 4'-oxonucleosides 5-8 as potent and selective A3AR antagonists were synthesized from D-mannose and D-erythronic acid γ-lactone, respectively. These nucleosides were evaluated for their anti-fibrotic renoprotectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::104924cacdba555bc5897349fe332e78
https://doi.org/10.1007/s12272-018-1079-2
https://doi.org/10.1007/s12272-018-1079-2
Autor:
Eddy Sotelo, Johan Åqvist, Vicente Yaziji, Hugo Gutiérrez-de-Terán, Ana Mallo, María Majellaro, María Isabel Cadavid, Willem Jespers, Olga Caamaño, María Isabel Loza, José Brea, Jhonny Azuaje
Publikováno v:
Journal of Medicinal Chemistry. 60:7502-7511
We report the first family of 2-acetamidopyridines as potent and selective A3 adenosine receptor (AR) antagonists. The computer-assisted design was focused on the bioisosteric replacement of the N1 atom by a CH group in a previous series of diarylpyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ee66046dc5144fdc2cde2bdb32f199a
https://doi.org/10.1021/acs.jmedchem.7b00860
https://doi.org/10.1021/acs.jmedchem.7b00860
Autor:
Raghu Prasad Mailavaram, Sonja Kachler, Khasim Shaik, A. M. Y. Jaber, Karl-Norbert Klotz, Pran Kishore Deb, Balakumar Chandrasekaran
Publikováno v:
Chemical Biology & Drug Design.
A series of novel 7-amino-5-oxo-2-substituted-aryl/hetero-aryl-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles (4a-4t) was synthesized, characterized and evaluated for their binding affinity and selectivity towards hA1 , hA2A , hA2B and hA3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e9663137f5520959d75430f0248ec2
https://doi.org/10.1111/cbdd.13528
https://doi.org/10.1111/cbdd.13528
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127274
Antagonists of the adenosine receptors (A1 and A2A subtypes) are widely researched as potential drug candidates for their role in Parkinson’s disease-related cognitive deficits (A1 subtype), motor dysfunction (A2A subtype) and to exhibit neuroprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9d1032161b7cd739d2c0da0caa7e1a
https://doi.org/10.1016/j.bmcl.2020.127274
https://doi.org/10.1016/j.bmcl.2020.127274
Autor:
Sonja Kachler, Rajwinder Kaur, Balakumar Chandrasekaran, Venkata Rao Kaki, Karl-Norbert Klotz, Raghuprasad Mailavaram, Pran Kishore Deb, Raghuram Rao Akkinepally
Publikováno v:
Chemical biologydrug design. 91(4)
A series of new molecules containing a thieno[2,3-d]pyrimidine scaffold was synthesized and characterized by adopting an efficient synthetic scheme. The effect of a free or substituted amino group at 2-position as well as an oxo-group, imidazole or 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edad4c8a26ffd1dbe3bf56a92878c7e
https://pubmed.ncbi.nlm.nih.gov/29194979
https://pubmed.ncbi.nlm.nih.gov/29194979
Autor:
Allan K Alencar, Tadeu L Montagnoli, Sharon S. Landgraf, Gisele Zapata-Sudo, Celso Caruso-Neves, Sharlene L Pereira, José Nascimento, Carlos Mauricio R. Sant'Anna, Roberto T. Sudo, Carlos A. M. Fraga, Arthur Eugen Kümmerle, Roberta Tesch, Eliezer J. Barreiro, Rodolfo C. Maia, Emanuelle B. Ferraz
Publikováno v:
British Journal of Pharmacology. 169:953-962
Background and Purpose Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, right ventricular hypertrophy and increased right ventricular systolic pressure. Here, we investigated the effects of a N-acylhyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::908e5ebd4a669957d2bc096772dc7a88
https://doi.org/10.1111/bph.12193
https://doi.org/10.1111/bph.12193
Autor:
Régis Gemerasca Mestriner, Carla Dalmaz, Juliana Bender Hoppe, Leonardo Machado Crema, Letícia Ferreira Pettenuzzo, Luisa Amalia Diehl, Daniela Pereira Laureano, Michele Schlabitz, Christianne Gazzana Salbego, Deusa Vendite
Publikováno v:
Physiology & Behavior. 109:1-7
This study examined the effects of two chronic stress regimens upon depressive-like behavior, A(1) and A(2A) adenosine receptor binding and immunocontent. Male rats were subjected to unpredictable chronic mild stress (UCMS) or to chronic restraint st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59bed7a140e0f5e6b3a73217dffb535
https://doi.org/10.1016/j.physbeh.2012.11.001
https://doi.org/10.1016/j.physbeh.2012.11.001
Autor:
Natarajan V. Bhanu, Jeffery L. Miller, Wulin Aerbajinai, Patricia A. Oneal, Y. Terry Lee, Craig J. Thomas, Pierre Noel, Nicole M. Gantt
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1782:504-510
In vivo, inhibition of fetal hemoglobin (HbF) expression in humans around the time of birth causes the clinical manifestation of sickle cell and beta-thalassemia syndromes. Inhibition of HbF among cultured cells was recently described by the adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13deaf12970b68f27370d3473d703a8
https://doi.org/10.1016/j.bbadis.2008.05.004
https://doi.org/10.1016/j.bbadis.2008.05.004
Autor:
Christine Blazynski, Helen McIntosh
Publikováno v:
Journal of Neurochemistry. 62:992-997
Previous work from this laboratory has shown that retinal adenosine A2 binding sites are localized over outer and inner segments of photoreceptors in rabbit and mouse retinal sections. In the present study, adenosine receptor binding has been charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c788fc54b65d9c2e27b3255c99c1d2a6
https://doi.org/10.1046/j.1471-4159.1994.62030992.x
https://doi.org/10.1046/j.1471-4159.1994.62030992.x