Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Adeno-Associated Viruses"'
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 9, Pp 819-829 (2024)
Abstract This study aimed to investigate the therapeutic potential of human adipose‐derived mesenchymal stem cells (hADSCs) modified with recombinant adeno‐associated virus (rAAV) carrying the vascular endothelial growth factor 165 (VEGF165) gene
Externí odkaz:
https://doaj.org/article/7be8f7442ef84c3a94643a1599ddb775
Autor:
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeut
Externí odkaz:
https://doaj.org/article/9a0782a3db1c490fbcc5b38f1bad9a21
Autor:
Kirsten Rosenmay Jacobsen, Javier Mota, Michelle Salerno, Alexis Willis, Dennis Pitts, Joachim Denner
Publikováno v:
Viruses, Vol 16, Iss 10, p 1613 (2024)
Adeno-associated viruses (AAV) are widely used as delivery vectors in clinical trials for in vivo gene therapy due to their unique features. Göttingen minipigs are a well-established animal model for several diseases and can be used for the efficacy
Externí odkaz:
https://doaj.org/article/a6c4fd2c8908408e8efd9c1170c4443a
Autor:
Mengyu Gao, YuTing He, XingLong Zhu, WanLiu Peng, YanYan Zhou, Yang Deng, Guangneng Liao, Wei Ni, Yi Li, Jun Gao, Hong Bu, Jiayin Yang, Guang Yang, Yang Yang, Ji Bao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Gene-edited pigs have become prominent models for studying human disease mechanisms, gene therapy, and xenotransplantation. CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated 9 (CRISPR/Cas9) technology
Externí odkaz:
https://doaj.org/article/8a89ef7b7afc40aaa7831e742aed142c
Autor:
Mojca Janc, Kaja Zevnik, Ana Dolinar, Tjaša Jakomin, Maja Štalekar, Katarina Bačnik, Denis Kutnjak, Magda Tušek Žnidarič, Lorena Zentilin, Dmitrii Fedorov, David Dobnik
Publikováno v:
Viruses, Vol 16, Iss 8, p 1235 (2024)
Recombinant adeno-associated viruses (rAAVs) play a pivotal role in the treatment of genetic diseases. However, current production and purification processes yield AAV-based preparations that often contain unwanted empty, partially filled or damaged
Externí odkaz:
https://doaj.org/article/4f69d64191ff470891c30bb36291e679
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 23, Iss 2, Pp 127-147 (2023)
Neurodegenerative diseases (NDDs) are promising objects for the development of gene therapy products, primarily, due to the possible cause of these diseases (disruption of a gene or several genes), lack of effective therapy, and negative impact on th
Externí odkaz:
https://doaj.org/article/116343dbca824d7ab63b9fc3b0f3d04d
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Gene therapy based on viral vectors offers great potential for the study and the treatment of cardiac diseases. Here we explore the use of Living Myocardial Slices (LMS) as a platform for nucleic acid-based therapies. Rat LMS and Adeno-Associated vir
Externí odkaz:
https://doaj.org/article/877f522399604deb93b5d65b05e6fb91
Akademický článek
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Akademický článek
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Autor:
Divya Ail, Duohao Ren, Elena Brazhnikova, Céline Nouvel-Jaillard, Stephane Bertin, Seyed Bagher Mirashrafi, Sylvain Fisson, Deniz Dalkara
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 306-316 (2022)
Positive clinical outcomes in adeno-associated virus (AAV)-mediated retinal gene therapy have often been attributed to the low immunogenicity of AAVs and immune privilege of the eye. However, several recent studies have shown potential for inflammato
Externí odkaz:
https://doaj.org/article/5f1307aa30894217bbe9ecb9a1d4feef