Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Adenine analog"'
Autor:
Dennis E. Kyle, Emma V Troth
Publikováno v:
Antimicrob Agents Chemother
Naegleria fowleri is a pathogenic free-living amoeba that is commonly found in warm freshwater and can cause a rapidly fulminant disease known as primary amoebic meningoencephalitis (PAM). New drugs are urgently needed to treat PAM, as the fatality r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647a8e5209ba80022b24ee53db2af457
https://doi.org/10.1128/aac.00017-21
https://doi.org/10.1128/aac.00017-21
Autor:
Emma V Troth, Dennis E. Kyle
Naegleria fowleri is a pathogenic free-living amoeba that is commonly found in warm, freshwater and can cause a rapidly fulminant disease known as primary amoebic meningoencephalitis (PAM). New drugs are urgently needed to treat PAM, as the fatality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e1310eb6b0c2936509f2a450f33df35
https://doi.org/10.1101/2021.01.07.425827
https://doi.org/10.1101/2021.01.07.425827
Publikováno v:
Current protocols in nucleic acid chemistryLiterature Cited. 81(1)
6-Methylpurine (MeP) is a cytotoxic adenine analog that does not exhibit selectivity when administered systemically and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli purine nucleoside phosphorylase (PN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3be1da766707291087319fbd4ce347
https://pubmed.ncbi.nlm.nih.gov/32255553
https://pubmed.ncbi.nlm.nih.gov/32255553
Autor:
Katsunori Horii, Masayasu Kuwahara, Yuka Kataoka, Iwao Waga, Ikuo Shiratori, Hirotaka Minagawa
Publikováno v:
Analytical biochemistry. 594
We used base-appended base modification to develop a new adenine analog, which incorporates an adenine derivative at position 7 of adenine. Using the systematic evolution of ligands by exponential enrichment method with a modified DNA library includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cf1c039f3e34ab6664ef7c0355ee81
https://pubmed.ncbi.nlm.nih.gov/32067984
https://pubmed.ncbi.nlm.nih.gov/32067984
Autor:
Abdalla E. A. Hassan, John A. Secrist, Paula W. Allan, Reham A. I. Abou-Elkhair, William B. Parker
Publikováno v:
Bioorganic Chemistry. 65:9-16
6-Methylpurine (MeP) is cytotoxic adenine analog that does not exhibit selectivity when administered systemically, and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli PNP. The prototype MeP releasing pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5f1b1f0795cb27c3e6660ae64956e4
https://doi.org/10.1016/j.bioorg.2015.12.006
https://doi.org/10.1016/j.bioorg.2015.12.006
Publikováno v:
Oncology Letters.
Toll-like receptor (TLR) 7/8 agonists have been applied in combination with chemo-, radio- or immunotherapy for lymphoma, and used as topical drugs for the treatment of viral skin lesions and skin tumors. In the present study, the role of an adenine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fefbf04c709c00b193afdd521c09c2
https://doi.org/10.3892/ol.2018.7954
https://doi.org/10.3892/ol.2018.7954
Autor:
Mark N. Prichard, Karoly Toth, Jacqueline F. Spencer, Ann E. Tollefson, Boris A. Kashemirov, Elke Lipka, Dawn Reyna, Caroll B. Hartline, Baoling Ying, Jinglei Lyu, Charles E. McKenna, Cheryl Harteg, William S. M. Wold, Eric T. Richard, Jiajun Fan
Publikováno v:
Antiviral research. 153
Human adenoviruses (AdV) cause generally mild infections of the respiratory and GI tracts as well as some other tissues. However, AdV can cause serious infection in severely immunosuppressed individuals, especially pediatric patients undergoing allog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfefd89ad299b1d45d9a01c75f6a13f
https://pubmed.ncbi.nlm.nih.gov/29510156
https://pubmed.ncbi.nlm.nih.gov/29510156
Autor:
Joon Hee Hong, Seyeon Kim
Publikováno v:
Bulletin of the Korean Chemical Society. 36:2484-2493
Racemic syntheses of novel 5′-deoxy-3′,5′,5′-trifluoro-apiose nucleoside phosphonic acid analogs were carried out from 1,3-dihydroxyacetone, to be used as antiviral agents. Nucleophilic displacement of the triflate intermediate with diethyl (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e8dd17a17aab3cfa3a8d565db722244
https://doi.org/10.1002/bkcs.10478
https://doi.org/10.1002/bkcs.10478
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849:1179-1187
The RNA Polymerase II C-terminal domain (CTD) kinase CDK12 has been implicated as a tumor suppressor and regulator of DNA damage response genes. Although much has been learned about CDK12 and its activity, due to the lack of a specific inhibitor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf29e6e7a5c307a189d06b831694a47
https://doi.org/10.1016/j.bbagrm.2015.07.010
https://doi.org/10.1016/j.bbagrm.2015.07.010
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 34:620-638
Efficient synthetic route to novel 4'-trifluoromethylated 5'-deoxycarbocyclic nucleoside phosphonic acids was described from α-trifluoromethyl-α,β-unsaturated ester. Coupling of purine nucleosidic bases with cyclopentanol using a Mitsunobu reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c6ae632b07717eb20abfeca7ac105a
https://doi.org/10.1080/15257770.2015.1047028
https://doi.org/10.1080/15257770.2015.1047028