Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adenine/analogs & derivatives"'
Autor:
Bernard Surial, Thanh Doco-Lecompte, Hansjakob Furrer, Charles Béguelin, Gilles Wandeler, Marcel Stöckle, Jan Fehr, Andri Rauch, Enos Bernasconi, Jean-Philippe Chave, Laura N Walti, Patrick Schmid, Noémie Boillat-Blanco, Huldrych F. Günthard
Publikováno v:
Journal of acquired immune deficiency syndromes, vol. 85, no. 2, pp. 227-232
Journal of Acquired Immune Deficiency Syndromes (1999)
Journal of Acquired Immune Deficiency Syndromes (1999)
Supplemental Digital Content is Available in the Text.
Background: Whereas tenofovir disoproxil fumarate (TDF) can lead to renal adverse events, tenofovir alafenamide (TAF) has a more favorable renal safety profile. However, the impact of replac
Background: Whereas tenofovir disoproxil fumarate (TDF) can lead to renal adverse events, tenofovir alafenamide (TAF) has a more favorable renal safety profile. However, the impact of replac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2994d50dcb69a3583b817f037786c8
https://pubmed.ncbi.nlm.nih.gov/32925387
https://pubmed.ncbi.nlm.nih.gov/32925387
Autor:
Caroline Protin, Fanny Gallais, Ben Allal, Sandra De Barros, Fabienne Thomas, Anne Quillet-Mary, Melanie White-Koning, Etienne Chatelut, Lucie Oberic, Loïc Dupré, Fabien Despas, Loïc Ysebaert
Publikováno v:
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, Springer Verlag, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, Springer Verlag, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Ibrutinib is used for the treatment of chronic lymphocytic leukemia and other lymphoid malignancies. The aim of this work is to develop a population pharmacokinetic model for ibrutinib and its dihydrodiol metabolite to quantify pharmacokinetic inter-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18466632280bd56f9f163b49b4fa5076
https://hal.science/hal-02989879/document
https://hal.science/hal-02989879/document
Autor:
Surial, Bernard, Cavassini, Matthias, Calmy, Alexandra, Fehr, Jan, Stöckle, Marcel, Bernasconi, Enos, Roth, Bianca, Fux, Christoph A, Kovari, Helen, Furrer, Hansjakob, Rauch, Andri, Wandeler, Gilles, Swiss HIV Cohort Study
Publikováno v:
BMC infectious diseases, vol. 19, no. 1, pp. 834
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Infectious Diseases
Surial, Bernard; Cavassini, Matthias; Calmy, Alexandra; Fehr, Jan; Stöckle, Marcel; Bernasconi, Enos; Roth, Bianca; Fux, Christoph A; Kovari, Helen; Furrer, Hansjakob; Rauch, Andri; Wandeler, Gilles (2019). Rates and predictors of switching to tenofovir alafenamide-containing ART in a nationwide cohort. BMC infectious diseases, 19(1), p. 834. BioMed Central 10.1186/s12879-019-4454-9
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Infectious Diseases
Surial, Bernard; Cavassini, Matthias; Calmy, Alexandra; Fehr, Jan; Stöckle, Marcel; Bernasconi, Enos; Roth, Bianca; Fux, Christoph A; Kovari, Helen; Furrer, Hansjakob; Rauch, Andri; Wandeler, Gilles (2019). Rates and predictors of switching to tenofovir alafenamide-containing ART in a nationwide cohort. BMC infectious diseases, 19(1), p. 834. BioMed Central 10.1186/s12879-019-4454-9
BackgroundTenofovir alafenamide (TAF)-containing combinations were introduced in Switzerland after October 2016 and are recommended over tenofovir disoproxil fumarate (TDF) in patients with osteoporosis or impaired renal function.MethodsWe included a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e4872fd47d082fd5c4208de5eb56dc
https://serval.unil.ch/resource/serval:BIB_33535700F126.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_33535700F126.P001/REF.pdf
Autor:
Louis Droogmans, Luc Ponchon, Emmanuelle Braud, Mélanie Etheve-Quelquejeu, Laura Iannazzo, Stephanie Oerum, Marjorie Catala, Pierre Barraud, Franck Brachet, Carine Tisné, Colette Atdjian
Publikováno v:
RNA Biology
RNA Biology, Taylor & Francis, 2019, 16 (6), pp.798-808. ⟨10.1080/15476286.2019.1589360⟩
RNA biology, 16 (6
RNA Biology, Taylor & Francis, 2019, 16 (6), pp.798-808. ⟨10.1080/15476286.2019.1589360⟩
RNA biology, 16 (6
RNA methyltransferases (MTases) catalyse the transfer of a methyl group to their RNA substrates using most-often S-adenosyl-L-methionine (SAM) as cofactor. Only few RNA-bound MTases structures are currently available due to the difficulties in crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67a8c5038ba2dd06b5cb710aa48236a
https://hal.archives-ouvertes.fr/hal-02353503/document
https://hal.archives-ouvertes.fr/hal-02353503/document
Autor:
Inês Bártolo, Perpétua Gomes, Inês V. Pinto, Nuno Taveira, Umbelina Caixas, Pedro Borrego, Fátima Gonçalves
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
New antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad33099c170bad98790b16b08156a38
https://hdl.handle.net/10400.26/30647
https://hdl.handle.net/10400.26/30647
Publikováno v:
Kosbar, T R, Sofan, M A, Waly, M A & Pedersen, E B 2015, ' Anti-parallel triplexes : Synthesis of 8-aza-7-deazaadenine nucleosides with a 3-aminopropynyl side-chain and its corresponding LNA analog ', Bioorganic & Medicinal Chemistry, vol. 23, no. 10, pp. 2458-2469 . https://doi.org/10.1016/j.bmc.2015.03.050
The phosphoramidites of DNA monomers of 7-(3-aminopropyn-1-yl)-8-aza-7-deazaadenine (Y) and 7-(3-aminopropyn-1-yl)-8-aza-7-deazaadenine LNA (Z) are synthesized, and the thermal stability at pH 7.2 and 8.2 of anti-parallel triplexes modified with thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978e19f7679ea64362d219857424ce3
https://doi.org/10.1016/j.bmc.2015.03.050
https://doi.org/10.1016/j.bmc.2015.03.050
Autor:
Michael F. Seidl
Publikováno v:
Nature Genetics 49 (2017) 6
Nature Genetics, 49(6), 823. Nature Publishing Group
Nature Genetics, 49(6), 823-824
Nature Genetics, 49(6), 823. Nature Publishing Group
Nature Genetics, 49(6), 823-824
A DNA modification - methylation of cytosines and adenines - has important roles in diverse processes such as regulation of gene expression and genome stability, yet until recently adenine methylation had been considered to be only a hallmark of prok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d16f7b2bcb82d53587ec1a81f8c4a4
https://dspace.library.uu.nl/handle/1874/381672
https://dspace.library.uu.nl/handle/1874/381672
Autor:
De Amicis E, Schiaffino L, Marina Boido, Elena Tamagno, Antonio Piras, Julien Puyal, Rosa M. Soler, Alessandro Vercelli, Valsecchi, Michela Guglielmotto, Ana Garcera
Publikováno v:
Repositorio Abierto de la UdL
Universitad de Lleida
Cell Death & Disease
Recercat. Dipósit de la Recerca de Catalunya
instname
Cell Death & Disease, vol. 8, no. 12, pp. 3223
Cell Death and Disease, Vol 8, Iss 12, Pp 1-16 (2017)
Universitad de Lleida
Cell Death & Disease
Recercat. Dipósit de la Recerca de Catalunya
instname
Cell Death & Disease, vol. 8, no. 12, pp. 3223
Cell Death and Disease, Vol 8, Iss 12, Pp 1-16 (2017)
Spinal muscular atrophy (SMA) is a recessive autosomal neuromuscular disease, due to homozygous mutations or deletions in the telomeric survival motoneuron gene 1 (SMN1). SMA is characterized by motor impairment, muscle atrophy, and premature death f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d804a1a0a85c34ffd2e27edc36fb511d
http://hdl.handle.net/10459.1/62332
http://hdl.handle.net/10459.1/62332
Autor:
Alexandra Calmy, Frank de Wolf, Robert S. Hogg, Nathalie Vallier, Manuel Battegay, Viviane D. Lima, Bernard Hirschel, Julio S. G. Montaner, Joep M. A. Lange, Alain Nguyen, Ferdinand W. N. M. Wit, Peter Reiss, Benita Yip
Publikováno v:
Antiviral Therapy, Vol. 14, No 7 (2009) pp. 931-938
Antiviral therapy, 14(7), 931-938. International Medical Press Ltd
Antiviral therapy, 14(7), 931-938. International Medical Press Ltd
Background Nevirapine (NVP) is often prescribed once daily in clinical practice in combination with a once daily nucleoside backbone. We investigated the relationship of NVP dosing with safety and efficacy. Methods Patients from the Dutch AIDS Therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a2f537254c8d4f63f02fa303da01c6
https://doi.org/10.3851/imp1418
https://doi.org/10.3851/imp1418
Publikováno v:
Annals of Neurology, vol. 66, no. 3, pp. 378-389
OBJECTIVE: To evaluate the contributions of autophagic, necrotic, and apoptotic cell death mechanisms after neonatal cerebral ischemia and hence define the most appropriate neuroprotective approach for postischemic therapy. METHODS: Rats were exposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c2427855a3b98cbcd2cc72a27c2a2b
https://doi.org/10.1002/ana.21714
https://doi.org/10.1002/ana.21714