Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Adenain"'
Autor:
Anna K. Belford, Nicole L. Welch, Diana V. Pastrana, Gabriel J. Starrett, Christopher B. Buck, Alberto Peretti, Michael J. Tisza
Publikováno v:
Virus Evolution
Polintons (also known as Mavericks) were initially identified as a widespread class of eukaryotic transposons named for their hallmark type B DNA polymerase and retrovirus-like integrase genes. It has since been recognized that many polintons encode
Akademický článek
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Publikováno v:
Journal of fish diseases. 42(3)
In Taiwan, a petechial haemorrhage disease associated with mortality has affected marbled eels (Anguilla marmorata). The eels were revealed to be infected with adomavirus (MEAdoV, previously recognized as a polyoma-like virus). In this study, cell li
Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis
Autor:
Thomas B. Adler, Alexander V. Statsyuk, Theresa Klemm, Stefan G. Kathman, Yesid A. Ramirez, Christoph A. Sotriffer, Eva Altmann, Caroline Kisker, Florian Sauer, Christian Tiesmeyer
Publikováno v:
ChemMedChem. 13(19)
Based on the similarity between the active sites of the deubiquitylating and deneddylating enzyme ChlaDub1 (Cdu1) and the evolutionary related protease adenain a target-hopping approach screening on a focused set of adenain inhibitors has been pursue
Autor:
Samu Melkko, N. Jarousse, David Archer Ellis, Finton Sirockin, A. Bernardi, Aengus Mac Sweeney, Paul Erbel, Paul Ramage, Philipp Grosche, Eva Altmann, Keith D. Combrink, Nicola Hughes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:438-443
Adenoviral infections are associated with a wide range of acute diseases, among which ocular viral conjunctivitis (EKC) and disseminated disease in immunocompromised patients. To date, no approved specific anti-adenoviral drug is available, but there
Adenoviruses belong to the family of Adenovirdae viruses. They cause many diseases, from common cold to life-threatening multiorgan diseases, weakening the immune system. They not only infect human beings, but also many other vertebrates. In humans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c2db0e5519d9132190205a344a49f8
https://doi.org/10.1016/b978-0-12-809712-0.00003-4
https://doi.org/10.1016/b978-0-12-809712-0.00003-4
Autor:
Eva Altmann, A. Bernardi, Paul Erbel, Aengus Mac Sweeney, N. Jarousse, Paul Ramage, Philipp Grosche, Keith D. Combrink, Nicola Hughes, David Archer Ellis, Samu Melkko, Finton Sirockin
Publikováno v:
ACS Medicinal Chemistry Letters. 5:937-941
The cysteine protease adenain is the essential protease of adenovirus and, as such, represents a promising target for the treatment of ocular and other adenoviral infections. Through a concise two-pronged hit discovery approach we identified tetrapep
Publikováno v:
Virology. 270:173-179
Adenoviruses encode a cysteine protease, adenain, required for uncoating and virion maturation. Adenain activity is regulated by an 11-amino-acid peptide cofactor thiol-bonded distal to the active site. Structural and experimental data suggest that t
Autor:
Joseph M. Weber
Publikováno v:
Methods in Molecular Medicine™ ISBN: 9781588299017
All adenoviruses (Ads) sequenced so far encode a single endopeptidase of the cysteine class, named adenain. The Ad2 adenain is a 204-residue, nearly inactive monomer, which is activated during virus maturation by an 11-residue cleavage fragment of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8828ae45bf5fa46e47674f19d6f153a9
https://doi.org/10.1007/978-1-59745-277-9_18
https://doi.org/10.1007/978-1-59745-277-9_18