Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adena S. Spiro"'
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35937 (2012)
The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ(9)-tetrahydrocannabinol (THC) has affinity for P-gp and
Externí odkaz:
https://doaj.org/article/364e65f05c8f459a8c22b8a216d1119e
Publikováno v:
Journal of Huntington's Disease. 5:285-296
Background Huntington's disease (HD) is a progressive neurodegenerative disease with no effective treatment or cure. Environmental enrichment has been used to slow processes leading to ageing and neurodegenerative diseases including HD. Phenolic phyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b957de7fb6b24a246e08282f52d21da
https://doi.org/10.3233/jhd-160204
https://doi.org/10.3233/jhd-160204
Publikováno v:
Neuropathology and Applied Neurobiology. 42:535-546
Aims Cholesterol plays an essential role in membrane structure and function, being especially important in the brain. Alteration of brain cholesterol synthesis and metabolism has been demonstrated in several Huntington's disease (HD) mouse and cell m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::147ffcd4ab8a08eb93b267b33f5207f0
https://doi.org/10.1111/nan.12286
https://doi.org/10.1111/nan.12286
Autor:
Andrew M. Jenner, Maria D. Ganfornina, Sonia Sanz Muñoz, Diego Sanchez, Hua Zhao, Kalani Ruberu, Tim Karl, Hongyun Li, Brett Garner, Adena S. Spiro, Eric Rassart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
et al.
Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed. Here, we crossed both apoD-nu
Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed. Here, we crossed both apoD-nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe20a07db123f93b4f01a2567fc4d82
https://doi.org/10.1016/j.neurobiolaging.2015.02.010
https://doi.org/10.1016/j.neurobiolaging.2015.02.010
Autor:
Anthony Cooper, Glenda M. Halliday, Brett Garner, Karen E. Murphy, Adena S. Spiro, Akiko Furuta, Sarah K. Abbott, Amanda M. Gysbers, Tomohiro Kabuta
Publikováno v:
Movement Disorders. 30:1639-1647
Lysosomes are the primary catabolic compartment for the degradation of intracellular proteins through autophagy. The presence of abnormal intracellular α-synuclein-positive aggregates in Parkinson's disease (PD) indicates that the degradative capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba825d696a5ec0e29ced37da3577b28
https://doi.org/10.1002/mds.26141
https://doi.org/10.1002/mds.26141
Autor:
Glenda M. Halliday, Andrew M. Jenner, Brett Garner, Marijka Batterham, Sarah K. Abbott, Adena S. Spiro
Publikováno v:
Journal of Parkinson's Disease. 5:175-185
Background Oxidative stress contributes to Parkinson's disease (PD) etiology. Although previous studies have focused on sources of free radical formation in brain regions affected by PD, less is known regarding changes in lipid composition and the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acc0e3aea345612047fb8cdbcc43dd8
https://doi.org/10.3233/jpd-140479
https://doi.org/10.3233/jpd-140479
Publikováno v:
Journal of Alzheimer's Disease. 42:1383-1396
Impairments in cognitive ability and widespread pathophysiological changes caused by neurotoxicity, neuroinflammation, oxidative damage, and altered cholesterol homeostasis are associated with Alzheimer's disease (AD). Cannabidiol (CBD) has been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd55b336c0e435dab7c9b95d450576
https://doi.org/10.3233/jad-140921
https://doi.org/10.3233/jad-140921
Autor:
Surabhi Bhatia, Andrew M. Jenner, Anthony S. Don, Adena S. Spiro, Kalani Ruberu, Nupur Kain, Brett Garner, Hongyun Li, Claire E. Shepherd, Jillian J. Kril
Publikováno v:
Journal of Alzheimer's Disease. 35:475-486
Previous studies indicate that apolipoprotein D (apoD) may have a lipid antioxidant function in the brain. We have shown that apoD can reduce free radical-generating lipid hydroperoxides to inert lipid hydroxides in a reaction that involves conversio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168cc3af22b5acdf6cb8d9b03b7c79bb
https://doi.org/10.3233/jad-122278
https://doi.org/10.3233/jad-122278
Autor:
Jonathon C. Arnold, Charlotte Klein, Jarrah R. Spencer, Alexander Wong, Thanh Huynh, Emily A Karanges, Leonora E. Long, Nathan Gunasekaran, Tim Karl, Adena S. Spiro, Xu-Feng Huang, Kelly Liu, Iain S. McGregor
Publikováno v:
Psychopharmacology. 218:443-457
Rationale The interactions between Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during chronic treatment, and at equivalent doses, are not well characterised in animal models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434bce5b023296e0f479e575ca4750cb
https://doi.org/10.1007/s00213-011-2342-0
https://doi.org/10.1007/s00213-011-2342-0
Publikováno v:
Journal of Huntington's disease. 4(4)
Background Cholesterol has essential functions in neurological processes that require tight regulation of synthesis and metabolism. Perturbed cholesterol homeostasis has been demonstrated in Huntington's disease, however the exact role of these chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f667c37e76faffe53bae36307d6da9
https://pubmed.ncbi.nlm.nih.gov/26639223
https://pubmed.ncbi.nlm.nih.gov/26639223