Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Aden K-Y. Chan"'
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scONE-seq: A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors
Autor: Lei Yu, Xinlei Wang, Quanhua Mu, Sindy Sing Ting Tam, Danson Shek Chun Loi, Aden K. Y. Chan, Wai Sang Poon, Ho-Keung Ng, Danny T. M. Chan, Jiguang Wang, Angela Ruohao Wu
Publikováno v: Science Advances. 9
Single-cell multi-omics can provide a unique perspective on tumor cellular heterogeneity. Most previous single-cell whole-genome RNA sequencing (scWGS-RNA-seq) methods demonstrate utility with intact cells from fresh samples. Among them, many are not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7425c513cc600910f602a34c070da6
https://doi.org/10.1126/sciadv.abp8901
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5
Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?
Autor: Nathalie Wong, Chit Chow, Aden K-Y. Chan, James Y.W. Lau, Paul A. Johnston, Herbert H. Loong, Xiaofan Ding, Maggie Cheung, Danny T-M. Chan, Wai Sang Poon, Alissa M. Wong
Publikováno v: Journal of Clinical Neuroscience. 78:400-402
Despite significant medical advances, glioblastoma multiforme (GBM) remains a formidable therapeutic challenge. Advent of targeted capture sequencing and patients-derived organoid cultures may hold the key to scientifically sound individualized treat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11dfc1c6d5a4f38d1fc032aa7eac135c
https://doi.org/10.1016/j.jocn.2020.04.107
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6
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p
Autor: Angela K. F. Lo, Liping Liu, Tingting Huang, Jinglin Zhang, Jun Yu, Yujuan Dong, Johnny S. H. Kwan, Alvin Ho-Kwan Cheung, Feng Wu, Kwok Wai Lo, Ka Fai To, Yi Pan, Yan Wang, Yuhang Zhou, Wei Kang, Alfred S. L. Cheng, Aden K. Y. Chan, Chi Chun Wong
Publikováno v: Oncogene
Fibroblast growth factors (FGFs) and their receptors are significant components during fundamental cellular processes. FGF18 plays a distinctive role in modulating the activity of both tumor cells and tumor microenvironment. This study aims to compre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8226633cd028dbd25ab0d50cd0fa70f
https://doi.org/10.1038/s41388-018-0430-x
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7
SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis
Autor: Alvin Ho-Kwan Cheung, Yuhang Zhou, William K.K. Wu, Ka Fai To, Bin Zhang, Wei Kang, Yujuan Dong, Jun Yu, Nathalie Wong, Jinglin Zhang, Feng Wu, Alfred S. L. Cheng, Tingting Huang, Aden K. Y. Chan, Johnny S. H. Kwan, Rui Yang, Chi Chun Wong, Weilin Li
Publikováno v: Oncogene
Slit-Robo GTPase-activating protein 1 (SRGAP1) functions as a GAP for Rho-family GTPases and downstream of Slit-Robo signaling. We aim to investigate the biological function of SRGAP1 and reveal its regulation by deregulated microRNAs (miRNAs) in gas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733b686bb60592293add3a2731a0631f
http://europepmc.org/articles/PMC5861093
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